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Kazuko Kobayashi

Hoffmann-La Roche

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Publication

Featured researches published by Kazuko Kobayashi.

Bioorganic & Medicinal Chemistry Letters | 2001

Synthesis and antifungal activities of novel 1,3-β-D-glucan synthase inhibitors. Part 1

Kazunao Masubuchi; Takehiro Okada; Masami Kohchi; Takeshi Murata; Masao Tsukazaki; Osamu Kondoh; Toshikazu Yamazaki; Yasuko Satoh; Yoshinori Ono; Toshiyuki Tsukaguchi; Kazuko Kobayashi; Naomi Ono; Tomoaki Inoue; Ikuo Horii; Nobuo Shimma

Highly potent 1,3-beta-D-glucan synthase inhibitors 10, 11 and 13 have been identified by the chemical modification of the fungicidal macrocyclic lipopeptidolactone, RO-09-3655 (1), isolated from the cultured broth of Deuteromycotinia spp. D-Ornithine derivative (10) showed improved antifungal activity in the systemic candidiasis model in mice and reduced hepatotoxicity in vitro, as compared with 1.

Environmental Health Perspectives | 2003

Mechanisms of benzene-induced hematotoxicity and leukemogenicity: cDNA microarray analyses using mouse bone marrow tissue.

Byung-Il Yoon; Guang-Xun Li; Kunio Kitada; Yasushi Kawasaki; Katsuhide Igarashi; Yukio Kodama; Tomoaki Inoue; Kazuko Kobayashi; Jun Kanno; Dae-Yong Kim; Tohru Inoue; Yoko Hirabayashi

Journal of Toxicological Sciences | 2002

DEVELOPMENT OF TELEMETRY SYSTEM IN THE COMMON MARMOSET : CARDIOVASCULAR EFFECTS OF ASTEMIZOLE AND NICARDIPINE

Ikuo Horii; Go Kito; Taiji Hamada; Tatsuya Jikuzono; Kazuko Kobayashi; Keitaro Hashimoto

Archive | 2001

Intranasal cyclic peptide formulations

Ikuo Horii; Kazuko Kobayashi; Nobuo Shimma; Akira Yanagawa

Archive | 2001

Nasally administrable cyclic peptide compositions

Ikuo Horii; Kazuko Kobayashi; Nobuo Shimma; Akira Yanagawa

Journal of Toxicological Sciences | 2002

COMPARATIVE TOXICOLOGICAL ASSESSMENT OF A WATER-SOLUBLE AZOLE ADMINISTERED BOTH ORALLY AND BY INTRAVENOUS CONTINUOUS INFUSION IN CYNOMOLGUS MONKEYS

Kazuko Kobayashi; Ikuo Horii

Journal of Toxicological Sciences | 2005

Investigation of culture conditions of rat cardiomyocytes for in vitro evaluation of cardiotoxicity 2 : Analysis of Collagen gel + Matrigel culture(Circulatory system, Proceedings of the 32nd Annual Meeting)

Akifumi Shioda; Tomoaki Inoue; Kazuko Kobayashi

Journal of Toxicological Sciences | 2005

Evaluation of drug-induced QT prolongation in conscious marmosets(Circulatory system, Proceedings of the 32nd Annual Meeting)

Toshiko Hara; Sachiko Sone; Nobuyuki Shishido; Shino Kuramoto; Kohnosuke Nakano; Hideko Onodera; Mitsuyasu Tabo; Kazuya Kimura; Kazuko Kobayashi

Archive | 2001

Nasally administrable antifungal cyclic peptide compositions

Ikuo Horii; Kazuko Kobayashi; Nobuo Shimma; Akira Yanagawa

Archive | 2001

Nasal verabreichbare cyclische antimykotische peptidzusammensetzungen Nasal administrable antifungal cyclic peptide compositions

Ikuo Horii; Kazuko Kobayashi; Nobuo Shimma; Akira Yanagawa

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Ikuo Horii

Pfizer

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Nobuo Shimma

Chugai Pharmaceutical Co.

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Tomoaki Inoue

Hoffmann-La Roche

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Akira Inomata

Eisai

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Akira Kawashima

Chugai Pharmaceutical Co.

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Jun Kanno

National Institutes of Health

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Kazunao Masubuchi

Hoffmann-La Roche

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Masami Kohchi

Hoffmann-La Roche

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Masao Tsukazaki

Hoffmann-La Roche

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Naomi Ono

Hoffmann-La Roche

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