Kazuo Yanada

Reductive coupling of carbonyl compounds to pinacols by using SmI2MeOH or SmI2Ti(OiPr)4MeOH systems

Abstract The coupling reaction of aromatic carbonyl compounds was performed with SmI 2 or SmI 2 Ti(O i Pr) 4 in methanol. Meso isomer was mainly produced in the presence of Ti(O i Pr) 4 .

Indium(III)-Catalyzed Tandem Reaction with Alkynylbenzaldehydes and Alkynylanilines to Heteroaromatic Compounds

Starting from ortho-alkynylbenzaldehydes and ortho-alkynylanilines, In(OTf)3-catalyzed synthesis of ring-condensed heteroaromatic compounds was developed via a domino intramolecular nucleophilic attack/intermolecular cycloaddition/dehydration reaction.

Reductive dehalogenation of aliphatic vic-dihalides with metallic samarium in a methanolic medium

In the title reaction, eight vic-dibromides and three vinylene dibromides gave the corresponding debromination products (alkenes and alkynes) at room temperature under neutral condition and an argon atmosphere. 2,3-Dibromosuccinic acid derivatives gave overreduction products or an unusual coupling dimer.

Promoting effect of na2SeO3 on the activity of MoO3 catalyst for nitroarenes reduction to amines with sodium borohydride

Abstract Sodium selenite enhances the catalytic activity of molybdenum(VI) oxide during the reduction of nitroarenes (XC6H4NO2, X = 4-CN, 4-CO2Et, H, 4-C1, 2-Me, 3-Me, 4-Me, 4-OMe) with sodium borohydride to arenamines (86–98 % yields) under mild conditions. X= 4-CN, 4-CO2Et, H, 4-Cl, 2-Me, 3-Me, 4-Me, 4-OMe in 86–98 % yields.

Selenium-catalysed reduction of aromatic nitro compounds to N-arylhydroxylamines

Metallic selenium catalyses the reduction of aromatic nitro compounds to the corresponding N-arylhydroxylamines with sodium borohydride under mild conditions.

Studies on the Preparation of 1,5-Methanoazocinoindole Based on Indolylborate

Conversion of piperidine (8), readily available from the palladium catalyzed tandem cyclization-cross-coupling reaction of indolylborate (6) with bromide (7), to 1H-1,5-methanoazocino[4,3-b]indole (15) through piperidine (14) was investigated.

Antibody against a novel, Myriocin (ISP-I)-based immunosuppressant, FTY720

An antibody was prepared by immunizing rabbits with an ovalbumin conjugate of 2-amino-2-(2-(4-(4-mercaptobutyl)phenyl)ethyl)propane-1,3-diol HCl (AMPD-4), which contains the essential structure of the novel immunosuppressant FTY720. As the antibody reacted to not only AMPD-4, but also FTY720, it should be useful for immunoassay of FTY720 in body fluids, tissues and cells.

Photolabilisation of the triphenylphosphine ligand in the aminocarbene complex [(η5-C5H5)Fe(CO)(PPh3)C(NHCH2Ph)Me]+ BF4–

Photolysis of [(η5-C5H5)Fe(CO)(PPh3)C(NHCH2Ph)Me]+ BF4– and related aminocarbene complexes leads to exclusive loss of the phosphine ligand rather than the carbon monoxide ligand.

Synthesis and reactivities of a novel flavoenzyme model, 5-deazaflavin with C2-symmetry

Abstract The title model compound represents a redox property of the active site of flavoenzymes and an environmental effect of the apoproteins. Its stereostructure was elucidated by 1 H-NMR spectra and energy minimum calculations. The stereoselectivity of this model was observed during the reaction with Me 2 PNPH, as NAD(P)H model.

Selenium-catalysed debromination of vic-dibromides to alkenes with cysteine or glutathione

Sodium selenite catalyses, under mild conditions, the reductive debromination of vic-dibromides [e.g., meso- or (±)-1,2-dibromo-1,2-diphenylethane, trans-10,11-dibromodibenzosuberone, 2,3-dibromo-1,3-Biphenyl-1-propanone, α,β-dibromobenzenepropanoic acid, and cholesterol dibromide] to alkenes in the presence of the thiols cysteine or glutathione.