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Featured researches published by Kazuya Iwai.


Journal of Biotechnology | 2010

Enzymatic synthesis of caffeic acid phenethyl ester analogues in ionic liquid

Atsushi Kurata; Yuki Kitamura; Shiori Irie; Shintaro Takemoto; Yoshiaki Akai; Yoshitaka Hirota; Tokio Fujita; Kazuya Iwai; Mina Furusawa; Noriaki Kishimoto

An efficient procedure for transesterification of methyl caffeate was developed to produce caffeic acid phenethyl ester analogues with Candida antarctica lipase B using an ionic liquid, 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide, as a solvent. The system provided 48.8mM 2-cyclohexylethyl caffeate and 46.9 mM 3-cyclohexylpropyl caffeate with conversion yields of 97.6% and 93.8%, respectively. Reusability of the system was investigated, and the yield of 4-phenylbutyl caffeate was increased from 30.4 to 45.7 mM when the transesterification was carried out under reduced pressure to remove a by-product, methanol. Additionally, we showed that both 2-cyclohexylethyl caffeate and 3-cyclohexylpropyl caffeate exhibit strong antiproliferative activities, which are comparable to that of 5-fluorouracil by MTT assay.


Bioscience, Biotechnology, and Biochemistry | 2012

Inhibitory Activity of Chlorogenic Acids in Decaffeinated Green Coffee Beans against Porcine Pancreas Lipase and Effect of a Decaffeinated Green Coffee Bean Extract on an Emulsion of Olive Oil

Yusaku Narita; Kazuya Iwai; Taiji Fukunaga; Osamu Nakagiri

A decaffeinated green coffee bean extract (DGCBE) inhibited porcine pancreas lipase (PPL) activity with an IC50 value of 1.98 mg/mL. Six different chlorogenic acids in DGCBE contributed to this PPL inhibition, accounting for 91.8% of the inhibitory activity. DGCBE increased the droplet size and decreased the specific surface area of an olive oil emulsion.


Bioscience, Biotechnology, and Biochemistry | 2011

Inhibitory Effect of a Hot Water Extract of Coffee “Silverskin” on Hyaluronidase

Mina Furusawa; Yusaku Narita; Kazuya Iwai; Taiji Fukunaga; Osamu Nakagiri

Coffee “silverskin” (CS) is a by-product of the roasting procedure for coffee beans. A CS extract (CS-ext) was found to have a high inhibitory effect against hyaluronidase. It seems that the higher-molecular-weight substances in CS-ext contributed most to the hyaluronidase inhibition, while acidic polysaccharides mainly composed of uronic acid played a major role in this hyaluronidase inhibition by CS-ext.


Journal of Agricultural and Food Chemistry | 2004

In vitro antioxidative effects and tyrosinase inhibitory activities of seven hydroxycinnamoyl derivatives in green coffee beans

Kazuya Iwai; Noriaki Kishimoto; Yukari Kakino; Kyo Mochida; Tokio Fujita


Biocontrol Science | 2005

In Vitro Antibacterial, Antimutagenic and Anti-Influenza Virus Activity of Caffeic Acid Phenethyl Esters

Noriaki Kishimoto; Yukari Kakino; Kazuya Iwai; Kyo Mochida; Tokio Fujita


Food Science and Technology Research | 2012

Study on the Postprandial Glucose Responses to a Chlorogenic Acid-Rich Extract of Decaffeinated Green Coffee Beans in Rats and Healthy Human Subjects

Kazuya Iwai; Yusaku Narita; Taiji Fukunaga; Osamu Nakagiri; Tomoyasu Kamiya; Motoya Ikeguchi; Yoshiaki Kikuchi


Journal of Molecular Catalysis B-enzymatic | 2011

Synthesis of 3-cyclohexylpropyl caffeate from 5-caffeoylquinic acid with consecutive enzymatic conversions in ionic liquid

Atsushi Kurata; Shintaro Takemoto; Tokio Fujita; Kazuya Iwai; Mina Furusawa; Noriaki Kishimoto


Applied Microbiology and Biotechnology | 2005

Chlorogenate hydrolase-catalyzed synthesis of hydroxycinnamic acid ester derivatives by transesterification, substitution of bromine, and condensation reactions

Noriaki Kishimoto; Yukari Kakino; Kazuya Iwai; Tokio Fujita


Journal of Agricultural and Food Chemistry | 2006

Efficient digestion and structural characteristics of cell walls of coffee beans.

Naoya Kasai; Ayako Konishi; Kazuya Iwai; Gou Maeda


Archive | 2009

Preventive against metabolic syndrome

Satsuki Fujiwara; Taiji Fukunaga; Nanaka Gotoda; Hiroshi Hosokawa; Kazuya Iwai; Yuji Kamiya; Ryotaro Kimura; Kana Kitaura; Osamu Nakagiri; Yoshihiko Narita; Takayuki Sugibuchi; Takashi Tamehiro; Masachika Tsuji; Atsuko Yamato; 理 中桐; 佳奈 北浦; 敦子 山戸; 和也 岩井; 奈々香 後藤田; 佳彦 成田; 良太郎 木村; 貴之 杉渕; 貴志 為廣; 泰司 福永; 雄志 紙谷; 博史 細川; 沙都姫 藤原; 将央 辻

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Naoya Kasai

Osaka Prefecture University

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Kenji Ozeki

Kanazawa Institute of Technology

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Motoaki Sano

Kanazawa Institute of Technology

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Takayuki Bogaki

Kanazawa Institute of Technology

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