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Featured researches published by Kei Watanuki.


Hepatology Research | 2011

Liver abscess caused by periodontal bacterial infection with Fusobacterium necrophorum

Masato Yoneda; Shingo Kato; Hironori Mawatari; Hiroyuki Kirikoshi; Kento Imajo; Koji Fujita; Hiroki Endo; Hirokazu Takahashi; Masahiko Inamori; Noritoshi Kobayashi; Kensuke Kubota; Satoru Saito; Iwai Tohnai; Kei Watanuki; Koichiro Wada; Shin Maeda; Atsushi Nakajima

Liver abscess is recognized as a life‐threatening disease. However, even in recent years, approximately 50% of liver abscess cases are considered to be cryptogenic. Here, we report a case of liver abscess associated with periodontal bacterial infection by Fusobacterium necrophorum, which is commonly found in the oropharyngeal flora. A 36‐year‐old man presented with fever and contrast‐enhanced abdominal computed tomography revealed multiple liver abscesses. F.necrophorum was isolated from oral smears, liver aspirates and blood samples. Liver abscesses caused by periodontal bacterial infection are rare, however, the incidence is expected to increase in the future, as periodontitis is extremely common and is on the rise as one of the most common chronic infections in the world. A systemic survey including periodontitis may be required for the exact diagnosis of the source of infection.


International Journal of Oral and Maxillofacial Surgery | 2008

Vertical distraction of a free vascularized osteocutaneous scapular flap in the reconstructed mandible for implant therapy

Makoto Hirota; Nobuyuki Mizuki; Toshinori Iwai; Kei Watanuki; Tomomichi Ozawa; Jiro Maegawa; Yoshiro Matsui; Iwai Tohnai

This paper describes a case of vertical distraction osteogenesis of a free vascularized osteocutaneous scapular flap in the reconstructed mandible before implant therapy. The patient was a 67-year-old woman with squamous cell carcinoma of the right lower gingiva. She underwent segmental mandibulectomy for tumor ablation and reconstruction with an osteocutaneous scapular flap. The distraction protocol, clinical course and implant therapy are presented. Through this procedure, the bone height of the scapular graft increased by 10mm. Implants with adequate length could be placed in the distracted area. Two years after masticatory loading, the condition of these implants was stable. Vertical distraction osteogenesis of the scapular flap was considered effective when performed before implant therapy, to facilitate postoperative functional and esthetic restoration after tumor resection.


Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology | 2008

Osteosynthesis and simultaneous irregular trifocal distraction osteogenesis for segmental mandibular defect after tumor ablative surgery: a case report

Makoto Hirota; Hiroshi Chikumaru; Yoshiro Matsui; Makoto Adachi; Shinjiro Aoki; Kei Watanuki; Tomomichi Ozawa; Toshinori lwai; Iwai Tohnai

OBJECTIVE This paper describes a case of secondary mandibular bone reconstruction performed to place dental implants. Osteosynthesis and simultaneous irregular trifocal distraction osteogenesis were documented. PATIENT The patient was a 51-year-old man with recurrent ameloblastoma of the mandible. Segmental mandibulectomy for tumor ablation and immediate mandibular reconstruction were performed. Because the volume of reconstructed bone was insufficient to place dental implants, trifocal distraction osteogenesis (vertical and horizontal distraction osteogenesis) was performed. Because the mandible had lost its continuity, osteosynthesis was performed simultaneously. RESULTS Through this procedure, the bone was well augmented. Absorption of the distracted bone was not seen. Adequate-length implants were placed. CONCLUSION Irregular trifocal distraction osteogenesis synchronized with osteosynthesis shortened the treatment period and produced stable bone augmentation for placement of dental implants. Therefore, this procedure could be indicated for complicated segmental mandibular bone defects.


International Journal of Oral and Maxillofacial Surgery | 2009

Mandibular reconstruction using 2-step bone transport in an irradiated cancer patient with type 2 diabetes mellitus

Yoshiro Matsui; Tatsuo Shirota; Toshinori Iwai; Tomomichi Ozawa; Kei Watanuki; Makoto Hirota; Iwai Tohnai; Jiro Maegawa

This report describes mandibular reconstruction using a 2-step bone transport technique in a cancer patient with type 2 diabetes mellitus (DM) who received radiotherapy before ablative surgery. The bone, measuring 90 mm in length with the mandibular curvature and good alveolar form, was regenerated using a plate-guided method. Three implants were placed 21 months after completion of the first distraction and 14 months after the second distraction. These implants integrated successfully and have remained stable more than 2 years after loading. The results suggest that mandibular reconstruction using bone transport is possible after segmental osteotomy in irradiated cancer patients with DM, although a long treatment period is required.


Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology | 2008

Management considerations in reconstruction of postablative defects of the mandible: vertical distraction of a scapular bone flap and removable lip support: a case report

Makoto Hirota; Yoshiro Matsui; Nobuyuki Mizuki; Tomokatsu Saito; Kei Watanuki; Toshinori Iwai; Iwai Tohnai

OBJECTIVE To describe vertical distraction osteogenesis of a scapular flap and removable lip support for oral rehabilitation after surgical creation of an ablative defect of the mandible. CASE REPORT A 70-year-old man who was diagnosed with squamous cell carcinoma of the left lower gingiva underwent segmental mandibulectomy for tumor ablation and reconstruction with a scapular bone flap. To augment bone height of this flap, vertical distraction osteogenesis was performed. After denture fabrication, a removable lip support was placed between the implant-supported denture and the lower lip. RESULTS The bone height of the scapular bone flap increased by 9 mm. Implants with adequate length could be placed in the distracted bone. The lip support was effective. Two years after masticatory loading, the implants remained stable. CONCLUSION Vertical distraction osteogenesis of the scapular bone flap was suitable to facilitate postoperative functional and esthetic restoration after tumor resection. A removable lip support was also useful as a supplementary tool for oral rehabilitation.


Annals of Nuclear Medicine | 2011

Assessment of tumor hypoxia by 62Cu-ATSM PET/CT as a predictor of response in head and neck cancer: a pilot study

Y. Minagawa; Kazuya Shizukuishi; Izumi Koike; Choichi Horiuchi; Kei Watanuki; Masaharu Hata; Motoko Omura; Kazumasa Odagiri; Iwai Tohnai; Tomio Inoue; Ukihide Tateishi


Dental Materials Journal | 2009

Combination with allogenic bone reduces early absorption of β-tricalcium phosphate (β-TCP) and enhances the role as a bone regeneration scaffold. Experimental animal study in rat mandibular bone defects

Makoto Hirota; Yoshiro Matsui; Nobuyuki Mizuki; Teruki Kishi; Kei Watanuki; Tomomichi Ozawa; Takafumi Fukui; Shihomi Shoji; Makoto Adachi; Yuka Monden; Toshinori Iwai; Iwai Tohnai


Journal of Hard Tissue Biology | 2009

Evaluation of Maxillary Sinus Floor Augmentation Using Mixture of Autogenous Bone and Highly Pure Porous β-tricalcium Phosphate (β-TCP):

Makoto Hirota; Yoshiro Matsui; Nobuyuki Mizuki; Kei Watanuki; Tomomichi Ozawa; Toshinori Iwai; Iwai Tohnai


Japanese Journal of Oral & Maxillofacial Surgery | 2005

A case of hereditary angioedema

Toshinori Iwai; Hiroshi Chikumaru; Makoto Hirota; Kei Watanuki; Ryoichi Kawabe; Kiyohide Fujita


Journal of Hard Tissue Biology | 2009

Efficacy of Tooth Extraction Wound Protection Made of Atelocollagen Sponge (TRE-641) : A Pilot Study in Dogs

Makoto Hirota; Nobuyuki Mizuki; Shinjiro Aoki; Susumu Omura; Kei Watanuki; Tomomichi Ozawa; Toshinori Iwai; Yoshiro Matsui; Iwai Tohnai

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Iwai Tohnai

Yokohama City University

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Toshinori Iwai

Yokohama City University

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Yoshiro Matsui

Yokohama City University

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Makoto Hirota

Yokohama City University

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Jiro Maegawa

Yokohama City University

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Kenji Mitsudo

Yokohama City University

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Makoto Adachi

Yokohama City University

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