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Featured researches published by Keiji Tanaka.


Journal of Biological Chemistry | 1999

Growth Retardation in Mice Lacking the Proteasome Activator PA28γ

Shigeo Murata; Hiroyuki Kawahara; Shigeto Tohma; Kazuhiko Yamamoto; Masanori Kasahara; Yo-ichi Nabeshima; Keiji Tanaka; Tomoki Chiba

The proteasome activator PA28 binds to both ends of the central catalytic machine, known as the 20 S proteasome, in opposite orientations to form the enzymatically active proteasome. The PA28 family is composed of three members designated α, β, and γ; PA28α and PA28β form the heteropolymer mainly located in the cytoplasm, whereas PA28γ forms a homopolymer that predominantly occurs in the nucleus. Available evidence indicates that the heteropolymer of PA28α and PA28β is involved in the processing of intracellular antigens, but the function of PA28γ remains elusive. To investigate the role of PA28γ in vivo, we generated mice deficient in the PA28γ gene. The PA28γ-deficient mice were born without appreciable abnormalities in all tissues examined, but their growth after birth was retarded compared with that of PA28γ+/− or PA28γ+/+ mice. We also investigated the effects of the PA28γ deficiency using cultured embryonic fibroblasts; cells lacking PA28γ were larger and displayed a lower saturation density than their wild-type counterparts. Neither the expression of PA28α/β nor the subcellular localization of PA28α was affected in PA28γ−/− cells. These results indicate that PA28γ functions as a regulator of cell proliferation and body growth in mice and suggest that neither PA28α nor PA28β compensates for the PA28γ deficiency.


Genetics of Movement Disorders | 2003

Parkin Mutations (Park 2)

Yoshikuni Mizuno; Nobutaka Hattori; Hiroyo Yoshino; Shiuchi Asakawa; Shinsei Minoshima; Nobuyoshi Shimizu; Toshiaki Suzuki; Tomoki Chiba; Keiji Tanaka

Publisher Summary Park2 (autosomal recessive-juvenile parkinsonism (AR-JP)) presents young-onset parkinsonism, consisting of gait disturbance, rest tremor, cogwheel rigidity, and bradykinesia. Clinical features are essentially similar to those of late-onset sporadic Parkinsons disease. They respond to levodopa well. Progression is slow. Pathologic features include extensive nigral and locus coeruleus degeneration and gliosis without Lewy body formation. The disease gene is identified and named parkin, which is located on the long arm of chromosome 6 at 6q25-27.2. Varieties of deletion mutations and point mutations of parkin are found in patients with Park2. Compound heterozygotes are also found. Parkin protein functions as a ubiquitin ligase and a number of candidate substrates for Parkin are reported including CDCrel 1, α-synuclein 22, Pael receptor, synphilin-1, and CDCrel 2A. Accumulation of one or more of the candidate substrates appears to be the cause of nigral degeneration. Park2 is considered to represent the most common form of familial Parkinsons disease.


Archive | 2004

Conditioned autophagy-deficient animal and disease model animal

Keiji Tanaka; Tomoki Chiba; Masaaki Komatsu


Archive | 2018

Cytosolic N‐Glycans: Triggers for Ubiquitination Directing Proteasomal and Autophagic Degradation

Yukiko Yoshida; Keiji Tanaka


The Japanese Biochemical Society/The Molecular Biology Society of Japan | 2017

The novel functions of ribosome ubiquitination upon UPR

Yasuko Matsuki; Yoshitaka Matsuo; Hideyuki Yoko; Shintaro Iwasaki; Tsuyoshi Udagawa; Yasushi Saeki; Keiji Tanaka; Nicholas T. Ingolia; Toshifumi Inada


The Japanese Biochemical Society/The Molecular Biology Society of Japan | 2017

Analysis of linker histone degradation by atypical polyubiquitin chains

Hikaru Tsuchiya; Naoko Arai; Ai Kaiho; Keiji Tanaka; Yasushi Saeki


The Japanese Biochemical Society/The Molecular Biology Society of Japan | 2017

Cytosolic deubiquitinating enzyme USP8 is endowed with a nuclear function by the mutation associated with Cushing's disease.

Kazuya Inoko; Takahiro Sawada; Akinori Endo; Yasushi Saeki; Keiji Tanaka; Ardisasmita Ibrahim; Toshiaki Fukushima; Masayuki Komada


The Japanese Biochemical Society/The Molecular Biology Society of Japan | 2017

Analysis of the K48-K63 branched ubiquitin chain in Saccharomyces cerevisiae

Arisa Kawano; Fumiaki Ohtake; Yasushi Saeki; Keiji Tanaka


The Japanese Biochemical Society/The Molecular Biology Society of Japan | 2017

Ubiquitination of exposed glycoproteins by SCF FBXO27 directs damaged lysosomes for autophagy

Yukiko Yoshida; Sayaka Yasuda; Yoshiharu Fujita; Maho Hamasaki; Arisa Murakami; Junko Kawawaki; Kazuhiro Iwai; Yasushi Saeki; Tamotsu Yoshimori; Noriyuki Matsuda; Keiji Tanaka


Archive | 2015

Method for Determining Ubiqutin Chain Length

Yasushi Saeki; Hikaru Tsuchiya; Ai Kaiho; Keiji Tanaka

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Tomoki Chiba

Graduate University for Advanced Studies

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Shigeo Murata

Graduate University for Advanced Studies

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Kazuhiko Yamamoto

Graduate University for Advanced Studies

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Shigeto Tohma

Graduate University for Advanced Studies

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