Keiko Ninomiya

X/π Interactions in Aromatic Heterocycles: Basic Principles and Recent Advances

This article outlines the basic principles and recent advances of XH/π interactions involving heteroaromatic molecules or moieties, which include π/π interactions, CH/π interactions, cation/π interactions, anion/π interactions, NH/π and OH/π interactions, and lone-pair/π interactions. Their fundamental features (such as interaction energies and favorable geometries) investigated by means of high-level theoretical calculations and statistical studies are described and compared to interactions involving aromatic hydrocarbons. Several typical or unique examples, where XH/π interactions play a significant role in construction of crystal and supramolecular structures and/or in modulating the properties are shown. The interplay of π/π interaction and hydrogen bonding is also mentioned.

Facile aminoacylation of pdCpA dinucleotide with a nonnatural amino acid in cationic micelleElectronic Supplementary Information (ESI) available: experimental procedure and spectral data for Pen-napAla-OCM and pdCpA-(Pen-napAla). See http://www.rsc.org/suppdata/cc/b3/b306011j/

A simple and versatile method for aminoacylation of a dinucleotide (pdCpA) in aqueous micellar solution was developed by using a hydrophobic amino acid derivative, N-pentenoyl-L-2-naphthylalanine cyanomethyl ester (Pen-napAla-OCM), and a CTACl micelle.

Simple and quick chemical aminoacylation of tRNA in cationic micellar solution under ultrasonic agitation

A simple and quick method for direct aminoacylation of a tRNA with a non-natural amino acid was developed by using an N-protected amino acid cyanomethyl ester as a substrate solubilized in CTACl micelle under ultrasonic agitation.

Photoactivated thiazole-based DNA-cleaving agents: dramatic change of recognition sequence depending on the number of thiazole units

By increasing the number of thiazole units in the photoactive DNA cleaving compounds, 4-(3-dimethylsulfoniopropyl-aminocarbonyl)-2-[2-(4-nitrobenzoylamino)ethyl] oligo- thiazole, from one or two to three, the specificity of their DNA cleavage was dramatically altered from 5′-AAATN-3′(N ≠ G) to 5′-GG-3′.