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Publication
Featured researches published by Keiko Takada.
Archives of Dermatological Research | 2006
Keiko Takada; Satoshi Amano; Yoshiyuki Kohno; Toshio Nishiyama; Shinji Inomata
Gelatinases, which belong to the family of matrix metalloproteinases, degrade various components of skin, and may be involved in photoaging, since they are upregulated by low-dose UV exposure to the skin. However, their behavior in healthy human skin is still unclear. In the present study, gelatinases was specifically detected in stratum corneum (SC) of skin from sun-exposed sites, including the face, in healthy humans, but not in SC of skin from unexposed sites. Following experimental UVB irradiation of the abdomen in volunteers, gelatinases were detected in tape-stripped SC from the site for several weeks, and subsequently disappeared. The appearance of gelatinase in SC after a lag time consistent with SC turnover is considered to reflect upregulation of gelatinase expression in keratinocytes in response to UVB-exposure of the skin. A survey of gelatinases in facial SC samples collected by tape-stripping from the cheeks of 100 healthy women revealed that the enzyme was present in 90% of subjects. These results, taken together, suggest that gelatinase is constantly upregulated by sunlight in the facial epidermis of most women during their daily lives, and may be an etiological factor in photoaging, e.g., by promoting wrinkle formation.
Journal of Investigative Dermatology | 2003
Shinji Inomata; Keiko Takada; Makoto Tsunenaga; Minoru Fukuda; Yukiko Matsunaga; Satoshi Amano; Kouji Kobayashi; Toshio Nishiyama; Yoshiyuki Kohno
Archive | 2002
Nobuhiko Ochiai; Shinji Inomata; Keiko Takada
Archive | 2009
Keiko Takada; Rikako Suzuki; Miki Guentert; Shinji Inomata; Chika Hamada; Takayuki Sakiguchi
Archive | 2004
Mikiko Kaminuma; Masaru Suetsugu; Toshii Iida; Shinji Inomata; Keiko Takada; Yuji Katsuta
Archive | 2006
Makoto Tsunenaga; Haruhi Iwaki; Toshii Iida; Mikiko Kaminuma; Masaru Suetsugu; Keiko Takada; Shinji Inomata
Archive | 2006
Keiko Takada; Shinji Inomata; Arinori Ogura; Kenichi Umishio
Archive | 2005
Shinji Inomata; Arinori Ogura; Keiko Takada; Kenichi Umishio; 有紀 小倉; 健一 海塩; 慎二 猪股; 恵子 高田
Archive | 2002
Keiko Takada; Satoshi Amano; Toshio Nishiyama
Archive | 2002
Satoshi Amano; Toshio Nishiyama; Keiko Takada; 聡 天野; 敏夫 西山; 恵子 高田