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Dive into the research topics where Keizo Watanabe is active.

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Featured researches published by Keizo Watanabe.


Journal of Chromatography B: Biomedical Sciences and Applications | 1981

Quantitative determination of tulobuterol and its metabolites in human urine by mass fragmentography

Kugako Matsumura; Osamu Kubo; Toshiko Sakashita; Yumiko Adachi; Hideo Kato; Keizo Watanabe; Masaaki Hirobe

A method is described for the simple and simultaneous determination of tulobuterol and its metabolites in human urine by gas chromatography--mass spectrometry. Quantification was achieved by single-ion monitoring at m/e 86 derived from trimethylsilyl-tulobuterol and its metabolites using a column packed with a mixed phase, 2% OV-1--2% QF-1 (1 : 1, w/w). The detection limits were estimated to be 2 ng/ml in urine for tulobuterol and 5 ng/ml for metabolites, respectively.


Chemical & Pharmaceutical Bulletin | 1980

Synthesis and Analgesic Activity of Morphine-7, 8-oxide and Heroin-7, 8-oxide

Naoki Miyata; Kiyoko Uba; Keizo Watanabe; Masaaki Hirobe


Journal of Chromatography B: Biomedical Sciences and Applications | 1982

Determination of tulobuterol in human serum by electron-capture gas—liquid chromatography

Kugako Matsumura; Osamu Kubo; Toshitaka Tsukada; Kazunori Nishide; Hideo Kato; Keizo Watanabe; Masaaki Hirobe


Japanese Journal of Pharmacology | 1981

Effects of epoxides of Heroin, Morphine and Codeine on the electrically stimulated guinea pig ileum.

Issei Takayanagi; Naoki Miyata; Kiyoko Uba; Keizo Watanabe; Masaaki Hirobe


Journal of Pharmaceutical Sciences | 1983

Determination of Serum Tulobuterol Concentrations by Mass Fragmentography: Comparison with an Electron-Capture Gas Chromatographic Method

Kugako Matsumura; Osamu Kubo; Toshiko Sakashita; Hideo Kato; Keizo Watanabe; Masaaki Hirobe


Japanese Journal of Pharmacology | 1982

Pharmacological properties of codeine-7,8-oxide (codeine epoxide), a new metabolite of codeine.

Issei Takayanagi; Fukio Konno; Naoki Miyata; Keizo Watanabe; Masaaki Hirobe


Chemical & Pharmaceutical Bulletin | 1979

Stereospecific Synthesis of Codeine 7, 8-Oxide and Codeinone 7, 8-Oxide

Kiyoko Uba; Naoki Miyata; Keizo Watanabe; Masaaki Hirobe


Chemical & Pharmaceutical Bulletin | 1980

Codeine-7,8-oxide (4,5 alpha-epoxy-7 beta, 8 beta-epoxy-3-methoxy-17-methyl-morphinan-6 alpha -ol: identification as a metabolite of codeine.

Kiyoko Uba; Naoki Miyata; Keizo Watanabe; Masaaki Hirobe


Journal of pharmacobio-dynamics | 1981

STUDIES ON THE METABOLISM OF MORPHINE・ALKALOIDS : SYNTHESIS AND ANALGESIC ACTIVITY OF 7,8-EPOXIDE AS A NEW METABOLITE

Naoki Miyata; Kiyoko Uba; Keizo Watanabe; Masaaki Hirobe


Yakugaku Zasshi-journal of The Pharmaceutical Society of Japan | 1982

[The simultaneous determination of Ara-U and Ara-C, urinary metabolites of N4-behenoyl-1-beta-D-arabinofuranosylcytosine by mass fragmentography (author's transl)].

Yukiko Makino; Yukio Matsubara; Keizo Watanabe; Masaaki Hirobe

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