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Journal of Chromatography B: Biomedical Sciences and Applications | 1981

Quantitative determination of tulobuterol and its metabolites in human urine by mass fragmentography

Kugako Matsumura; Osamu Kubo; Toshiko Sakashita; Yumiko Adachi; Hideo Kato; Keizo Watanabe; Masaaki Hirobe

A method is described for the simple and simultaneous determination of tulobuterol and its metabolites in human urine by gas chromatography--mass spectrometry. Quantification was achieved by single-ion monitoring at m/e 86 derived from trimethylsilyl-tulobuterol and its metabolites using a column packed with a mixed phase, 2% OV-1--2% QF-1 (1 : 1, w/w). The detection limits were estimated to be 2 ng/ml in urine for tulobuterol and 5 ng/ml for metabolites, respectively.


Archive | 1984

Antiinflammatory and antipyretic cream

Yasuo Itoh; Hideo Kato; Kugako Matsumura; Tomoyasu Nishikawa; Akira Hisano; Takehisa Yamada; Eiichi Koshinaka


Journal of Chromatography B: Biomedical Sciences and Applications | 1982

Determination of tulobuterol in human serum by electron-capture gas—liquid chromatography

Kugako Matsumura; Osamu Kubo; Toshitaka Tsukada; Kazunori Nishide; Hideo Kato; Keizo Watanabe; Masaaki Hirobe


Journal of Pharmaceutical Sciences | 1983

Determination of Serum Tulobuterol Concentrations by Mass Fragmentography: Comparison with an Electron-Capture Gas Chromatographic Method

Kugako Matsumura; Osamu Kubo; Toshiko Sakashita; Hideo Kato; Keizo Watanabe; Masaaki Hirobe


Chemical & Pharmaceutical Bulletin | 1982

Studies on the Relationship between Physico-chemical Properties and Crystalline Forms of Tulobuterol Hydrochloride. I. Polymorphism of Tulobuterol Hydrochloride

Masaru Saito; Haruo Yabu; Masahiro Yamazaki; Kugako Matsumura; Hideo Kato


Chemical & Pharmaceutical Bulletin | 1982

Studies on the Relationship between Physico-chemical Properties and Crystalline Forms of Tulobuterol Hydrochloride. II. Crystal Structure Analyses of the Four Crystalline Forms of Tulobuterol Hydrochloride

Yoshinori Harada; Masaru Saito; Kugako Matsumura; Hideo Kato; Yoichi Iitaka


Yakugaku Zasshi-journal of The Pharmaceutical Society of Japan | 1981

[Studies on the metabolic fate of tulobuterol. V. Species differences in the metabolism and excretion in rat, dog, guinea pig and rabbit (author's transl)].

Kugako Matsumura; Yoshio Takahara; Takayuki Aratani; Kazunori Nishide; Hideo Kato; Noriki Kiriyama


岐阜藥科大學紀要 = The annual proceedings of Gifu College of Pharmacy | 1984

塩酸ツロブテールの性状と結晶形との相関に関する研究(第3報) : 塩酸ツロブテール多形の吸湿特性

勝 斉藤; 昌弘 山崎; 阜子 松村; 日出男 加藤; 安夫 伊藤; 嘉明 川島; 英雄 竹中; マサル サイトウ; マサヒロ ヤマザキ; クガコ マツムラ; ヒデオ カトウ; ヤスオ イトウ; ヨシアキ カワシマ; ヒデオ タケナカ; Masaru Saito; Masahiro Yamazaki; Kugako Matsumura; Hideo Kato; Yasuo Ito; Yoshiaki Kawashima; Hideo Takenaka


Archive | 1984

Creme anti-inflammatoire et antipyretique

Yasuo Itoh; Hideo Kato; Kugako Matsumura; Tomoyasu Nishikawa; Akira Hisano; Takehisa Yamada; Eiichi Koshinaka


Yakugaku Zasshi-journal of The Pharmaceutical Society of Japan | 1983

塩酸ツロブテロールの性状と結晶形との相関に関する研究(第3報)塩酸ツロブテロール多形の吸湿特性

Masaru Saito; Masahiro Yamazaki; Kugako Matsumura; Hideo Kato; Yasuo Ito; Yoshiaki Kawashima; Hideo Takenaka

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