Kenneth M. Ryan

The behavior of indene oxide in the ritter reaction: A simple route to cis-aminoindanol

Abstract A regio- and stereoselective synthesis of cis-1-aminoindan-2-ol via a Ritter reaction is described.

A practical synthesis of (±)-thienamycin

Abstract An efficient and operationally simple synthesis of (±)-thienamycin is described.

THE ROLE OF 4-(3-PHENYLPROPYL)PYRIDINE N-OXIDE (P3NO) IN THE MANGANESE-SALEN-CATALYZED ASYMMETRIC EPOXIDATION OF INDENE

Abstract 4-(3-Phenylpropyl)pyridine N-Oxide (P 3 NO) has provided a more active and stable catalytic media for manganese-salen complex 1 in the asymmetric epoxidation of indene.

Regio- and stereocontrolled syntheses of cyclic chiral cis-amino alcohols from 1,2-diols or epoxides

Abstract The behavior of 1,2-dioxygen derivatives of indane, tetralin, and benzosuberane in acetonitrile-strong acid media is exploited in the regio- and stereocontrolled syntheses of chiral cis-amino alcohols.

A diastereospecific, non-racemic synthesis of the C.10–C.18 segment of FK-506

Abstract An efficient stereocontrolled route to construct the C.10–C.18 moiety of FK-506 is reported.

Further studies on the acetonedicarboxylate route to thienamycin—stereochemical inversion at the lactone stage.

Abstract Stereochemical inversion of an easily prepared δ-lactone has culiminated in the preparation of a key intermediate for the synthesis of thienamycin.

Alkylation of chiral prolinol propionamide enolates with epoxides: complete reversal of predicted facial selectivity

Abstract The title transformation provided a rapid and efficient synthesis of syn and anti 2-methyl-4-hydroxylcarboxylic ester arrays.

Enhanced reactivity of iminium ions as heterodienophiles in Lewis acid mediated 4+2 cycloaddition reactions

Abstract The use of a Lewis acid-proton acid combination was found to be highly effective for the activation of imines as heterodienophiles in Diels-Alder cycloaddition reactions.