Kevin Bourque
Thoratec
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Publication
Featured researches published by Kevin Bourque.
Asaio Journal | 2007
David J. Farrar; Kevin Bourque; Charles Dague; Christopher J. Cotter; Victor Poirier
A long-term left ventricular assist system for permanent use in advanced heart failure is being developed on the basis of a compact centrifugal pump with a magnetically levitated rotor and single-fault–tolerant electronics. Key features include its “bearingless” (magnetic levitation) design, textured surfaces similar to the HeartMate XVE left ventricular assist device (LVAD) to reduce anticoagulation requirements and thromboembolism, a sensorless flow estimator, and an induced pulse mode for achieving an increased level of pulsatility with continuous flow assistance. In vitro design verification testing is underway. Preclinical testing has been performed in calves demonstrating good in vivo performance at an average flow rate of 6 L/min (maximum: >11 L/min) and normal end-organ function and host response. Induced pulse mode demonstrated the ability to produce a physiological pulse pressure in vivo. Thirteen LVADs have achieved between 16 to 40 months of long-term in vitro reliability testing and will be continued until failure. Both percutaneous and fully implanted systems are in development, with a modular connection for upgrading without replacing the LVAD.
Asaio Journal | 2001
Kevin Bourque; D. Gernes; Howard M. Loree; J. Scott Richardson; Victor Poirier; Natale Barletta; Andreas Fleischli; Giampiero Foiera; Thomas M. Gempp; Reto Schoeb; Kenneth N. Litwak; Takehide Akimoto; Mary J. Watach; Philip Litwak
A long-term, compact left ventricular assist device (LVAD), the HeartMate III, has been designed and fabricated, featuring a centrifugal pump with a magnetically levitated rotor. The pump has been optimized by in vitro testing to achieve a design point of 7 L/min against 135 mm Hg at high hydrodynamic efficiency (30%) and to be capable of up to 10 L/min under such a load. Furthermore, the pump has demonstrated no mechanical failures, low hemolysis (4–10 mg/dl plasma free Hb), and low thrombogenicity during six (40, 27, 59, 42, 27, and 49-day) in vivo bovine studies.
Asaio Journal | 2016
Kevin Bourque; Christopher James Cotter; Charles Dague; Daniel Harjes; Onur Dur; Julien Duhamel; Kaitlyn Spink; Kelly Walsh; Edward Burke
The HeartMate 3 (HM3) left ventricular assist device (LVAD) is designed to support advanced heart failure patients. This centrifugal flow pump has a magnetically levitated rotor, artificial pulse, textured blood-contacting surfaces, optimized fluid dynamics, large blood-flow gaps, and low shear stress. Preclinical tests were conducted to assess hemocompatibility. A computational fluid dynamics (CFD) model guided design for low shear stress and sufficient washing. Hemolysis testing was conducted on six pumps. Plasma-free hemoglobin (PfHb) and modified index of hemolysis (MIH) were compared with HeartMate II (HMII). CFD showed secondary flow path residence times between 27 and 798 min, comparable with main flow residence times between 118 and 587 min; HM3 vs. HMII shear stress exposure above 150 Pa was 3.3 vs. 11 mm3 within the pump volume and 134 vs. 604 mm2 on surfaces. In in vitro hemolysis tests at 2, 5, and 10 L/min, average pfHb 6 hours after test initiation was 58, 74, and 157 mg/dl, compared with 112, 123, and 353 mg/dl for HMII. The HM3/HMII ratio of average MIH at 2, 5, and 10 L/min was 0.29, 0.36, and 0.22. Eight 60 day bovine implants were tested with average flow rates from 5.6 to 6.4 L/min with no device failures, thrombosis, or hemolysis. Results support advancing HM3 to clinical trials.
Heart Failure Reviews | 2014
Tohid Pirbodaghi; Siavash S. Asgari; Chris Cotter; Kevin Bourque
Over the past few decades, advances in ventricular assist device (VAD) technology have provided a promising therapeutic strategy to treat heart failure patients. Despite the improved performance and encouraging clinical outcomes of the new generation of VADs based on rotary blood pumps (RBPs), their physiologic and hematologic effects are controversial. Currently, clinically available RBPs run at constant speed, which results in limited control over cardiac workload and introduces blood flow with reduced pulsatility into the circulation. In this review, we first provide an update on the new challenges of mechanical circulatory support using rotary pumps including blood trauma, increased non-surgical bleeding rate, limited cardiac unloading, vascular malformations, end-organ function, and aortic valve insufficiency. Since the non-physiologic flow characteristic of these devices is one of the main subjects of scientific debate in the literature, we next emphasize the latest research regarding the development of a pulsatile RBP. Finally, we offer an outlook for future research in the field.
Artificial Organs | 2014
Tohid Pirbodaghi; Chris Cotter; Kevin Bourque
We investigated the power consumption of a HeartMate III rotary blood pump based on in vitro experiments performed in a cardiovascular simulator. To create artificial-pulse mode, we modulated the pump speed by decreasing the mean speed by 2000 rpm for 200 ms and then increasing speed by 4000 rpm (mean speeds plus 2000 rpm) for another 200 ms, creating a square waveform shape. The HeartMate III was connected to a cardiovascular simulator consisting of a hydraulic pump system to simulate left ventricle pumping action, arterial and venous compliance chambers, and an adjustable valve for peripheral resistance to facilitate the desired aortic pressure. The simulator operated based on Sugas elastance model to mimic the Starling response of the heart, thereby reproducing physiological blood flow and pressure conditions. We measured the instantaneous total electrical current and voltage of the pump to evaluate its power consumption. The aim was to answer these fundamental questions: (i) How does pump speed modulation affect pump power consumption? (ii) How does the power consumption vary in relation to external pulsatile flow? The results indicate that speed modulation and external pulsatile flow both moderately increase the power consumption. Increasing the pump speed reduces the impact of external pulsatile flow.
Artificial Organs | 2001
Howard M. Loree; Kevin Bourque; David B. Gernes; J. Scott Richardson; Victor Poirier; Natale Barletta; Andreas Fleischli; Giampiero Foiera; Thomas M. Gempp; Reto Schoeb; Kenneth N. Litwak; Takehide Akimoto; Marina V. Kameneva; Mary J. Watach; Philip Litwak
Archive | 2009
Charles Dague; Kevin Bourque
Artificial Organs | 2006
Kevin Bourque; Charles Dague; David J. Farrar; Kelly M. Harms; Dan Tamez; William E. Cohn; Egemeun Tuzun; Victor Poirier; O. Howard Frazier
Archive | 2015
Kevin Bourque
Artificial Organs | 2004
Greg W. Burgreen; Howard M. Loree; Kevin Bourque; Charles Dague; Victor Poirier; David J. Farrar; Edward Hampton; Z. Jon Wu; Thomas Gempp; Reto Schöb