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Kimio Kawano

Bristol-Myers Squibb

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Featured researches published by Kimio Kawano.

Tetrahedron | 1999

Isolation and structure determination of TMC-151s: Novel polyketide antibiotics from Gliocladium catenulatum Gilman & Abbott TC 1280.

Jun Kohno; Maki Nishio; Masaaki Sakurai; Kimio Kawano; Hajime Hiramatsu; Noriaki Kameda; Noboru Kishi; Toyoharu Yamashita; Toru Okuda; Saburo Komatsubara

Abstract Six new antibiotics, TMC-151 A-F (2–7) have been isolated from organic extracts of the fermentation broth of Gliocladium catenulatum Gilman & Abbott TC 1280, isolated from a soil sample. Their structures including the absolute stereochemistries, were determined by extensive analyses of NMR and X-ray crystallography, and degradation studies. TMC-151s are novel polyketides containing D-mannopyranoside and D-mannitol or D-arabitol. These antibiotics showed moderate cytotoxicity to several tumor cell lines.

The Journal of Antibiotics | 1993

TERPESTACIN, A NEW SYNCYTIUM FORMATION INHIBITOR FROM Arthrinium sp.

Masahisa Oka; Seiji Iimura; Osamu Tenmyo; Yosuke Sawada; Masaru Sugawara; Noriyuki Ohkusa; Haruaki Yamamoto; Kimio Kawano; Shiu-Lok Hu; Yasuo Fukagawa; Toshikazu Oki

The Journal of Antibiotics | 1991

Fluvirucins A1, A2, B1, B2, B3, B4 and B5, new antibiotics active against influenza A virus. I. Production, isolation, chemical properties and biological activities.

Nobuaki Naruse; Osamu Tenmyo; Kimio Kawano; Koji Tomita; Noriyuki Ohgusa; Takeo Miyaki; Masataka Konishi; Toshikazu Oki

The Journal of Antibiotics | 1995

Siamycins I and II, New Anti-HIV Peptides: I. Fermentation, Isolation, Biological Activity and Initial Characterization

Mitsuaki Tsunakawa; Shu-Lok Hu; Yutaka Hoshino; David J. Detlefson; Susan E. Hill; Tamotsu Furumai; Richard J. White; Maki Nishio; Kimio Kawano; Satoshi Yamamoto; Yasuo Fukagawa; Toshikazu Oki

Organic Letters | 2003

TMC-264, a Novel Antiallergic Heptaketide Produced by the Fungus Phoma sp. TC 1674

Masaaki Sakurai; Maki Nishio; Kouzou Yamamoto; Toru Okuda; Kimio Kawano; Tetsuo Ohnuki

The Journal of Antibiotics | 2002

TMC-256A1 and C1, New Inhibitors of IL-4 Signal Transduction Produced by Aspergillus niger var niger TC 1629

Masaaki Sakurai; Jun Kohno; Kouzou Yamamoto; Toru Okuda; Maki Nishio; Kimio Kawano; Tetsuo Ohnuki

The Journal of Antibiotics | 2003

TMC-264, a Novel Inhibitor of STAT6 Activation Produced by Phoma sp. TC 1674

Masaaki Sakurai; Maki Nishio; Kouzou Yamamoto; Toru Okuda; Kimio Kawano; Tetsuo Ohnuki

The Journal of Antibiotics | 1996

TMC-1 A, B, C and D, New Antibiotics of the Manumycin Group Produced by Streptomyces sp. Taxonomy, Production, Isolation, Physico-chemical Properties, Structure Elucidation and Biological Properties

Jun Kohno; Maki Nishio; Kimio Kawano; Noriyuki Nakanishi; Shinichi Suzuki; Tomofumi Uchida; Saburo Komatsubara

The Journal of Antibiotics | 1995

Siamycins I and II, new anti-HIV-1 peptides: II. Sequence analysis and structure determination of siamycin I.

David J. Detlefsen; Susan E. Hill; Kevin J. Volk; Steven E. Klohr; Mltsuaki Tsunakawa; Tamotsu Furumai; P. F. Lin; Maki Nishio; Kimio Kawano; Toshikazu Oki; Mike S. Lee

The Journal of Antibiotics | 1992

New antiviral antibiotics, cycloviracins B1 and B2. I: Production, isolation, physico-chemical properties and biological activity

Mltsuaki Tsunakawa; Nobujiro Komiyama; Osamu Tenmyo; Koji Tomita; Kimio Kawano; Chikako Kotake; Masataka Konishi; Toshikazu Oki

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Maki Nishio

Bristol-Myers Squibb

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Jun Kohno

Mitsubishi Chemical Corporation

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Toru Okuda

Tamagawa University

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Toshikazu Oki

Tamagawa University

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Osamu Tenmyo

Bristol-Myers Squibb

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Shinichi Suzuki

Mitsubishi Chemical Corporation

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Hideo Kamei

Bristol-Myers Squibb

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Koji Tomita

Bristol-Myers Squibb

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Masataka Konishi

Bristol-Myers Squibb

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Mltsuaki Tsunakawa

Bristol-Myers Squibb

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