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Osamu Tenmyo

Bristol-Myers Squibb

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Publication

Featured researches published by Osamu Tenmyo.

Antiviral Chemistry & Chemotherapy | 1992

Anti-human immunodeficiency virus (HIV) activity of the novel antiviral antibiotic quartromicins which enhance inhibitory effect of 3'-azido-2',3'-dideoxythymidine (AZT) in vitro

A. Tanabe-Tochikura; H. Nakashima; T. Murakami; Osamu Tenmyo; Toshikazu Oki; Naoki Yamamoto

Novel antiviral antibiotic quartromicins A1 and D1, isolated from Amycolatopsis orientalis, significantly inhibited human immunodeficiency virus (HIV)-induced cytopathic effect and virus specific antigen expression at concentrations of 25–100 μg ml−1 In MT-4 cells infected with HTLV-IIIB. The reverse transcriptase activity of disrupted HTLV-IIIB particles, recombinant HIV-1 enzyme, and purified avian myeloblastosis virus (AMV) enzyme were also significantly inhibited by quartromicins A1 and D1. The combined antiviral effect of quartromicin A1 and AZT on the replication of HIV in MT-4 cells was also examined. Quartromicin A1 synergistically enhanced the inhibitory effect of AZT as revealed by HIV-specific antigen expression.

The Journal of Antibiotics | 1990

PUMILACIDIN, A COMPLEX OF NEW ANTIVIRAL ANTIBIOTICS

Nobuaki Naruse; Osamu Tenmyo; Seikichi Kobaru; Hideo Kamei; Takeo Miyaki; Masataka Konishi; Toshikazu Oki

The Journal of Antibiotics | 1988

Inhibitory effect of new antibiotic, pradimicin A on infectivity, cytopathic effect and replication of human immunodeficiency virus in vitro.

Akiko Tanabe; Hideki Nakashima; Osamu Yoshida; Naoki Yamamoto; Osamu Tenmyo; Toshikazu Oki

The Journal of Antibiotics | 1990

Pradimicins A, B and C : new antifungal antibiotics. II, In vitro and in vivo biological activities

Toshikazu Oki; Osamu Tenmyo; Minoru Hirano; Kozo Tomatsu; Hideo Kamei

The Journal of Antibiotics | 1993

TERPESTACIN, A NEW SYNCYTIUM FORMATION INHIBITOR FROM Arthrinium sp.

Masahisa Oka; Seiji Iimura; Osamu Tenmyo; Yosuke Sawada; Masaru Sugawara; Noriyuki Ohkusa; Haruaki Yamamoto; Kimio Kawano; Shiu-Lok Hu; Yasuo Fukagawa; Toshikazu Oki

The Journal of Antibiotics | 1989

Lanthiopeptin, a new peptide antibiotic. Production, isolation and properties of lanthiopeptin.

Nobuaki Naruse; Osamu Tenmyo; Koji Tomita; Masataka Konishi; Takeo Miyaki; Hiroshi Kawaguchi; Koichi Fukase; Tateaki Wakamiya; Tetsuo Shiba

The Journal of Antibiotics | 1991

Fluvirucins A1, A2, B1, B2, B3, B4 and B5, new antibiotics active against influenza A virus. I. Production, isolation, chemical properties and biological activities.

Nobuaki Naruse; Osamu Tenmyo; Kimio Kawano; Koji Tomita; Noriyuki Ohgusa; Takeo Miyaki; Masataka Konishi; Toshikazu Oki

The Journal of Antibiotics | 1992

Quartromicin, a complex of novel antiviral antibiotics. I. Production, isolation, physico-chemical properties and antiviral activity.

Mitsuaki Tsunakawa; Osamu Tenmyo; Koji Tomita; Nobuaki Naruse; Chikako Kotake; Takeo Miyaki; Masataka Konishi; Toshikazu Oki

The Journal of Antibiotics | 1993

New antiviral antibiotics, kistamicins A and B. I. Taxonomy, production, isolation, physico-chemical properties and biological activities.

Nobuaki Naruse; Osamu Tenmyo; Seikichi Kobaru; Masami Hatori; Koji Tomita; Yasutaro Hamagishi; Toshikazu Oki

The Journal of Antibiotics | 1992

New antiviral antibiotics, cycloviracins B1 and B2. I: Production, isolation, physico-chemical properties and biological activity

Mltsuaki Tsunakawa; Nobujiro Komiyama; Osamu Tenmyo; Koji Tomita; Kimio Kawano; Chikako Kotake; Masataka Konishi; Toshikazu Oki

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Collaboration

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Masataka Konishi

Bristol-Myers Squibb

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Toshikazu Oki

Tamagawa University

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Takeo Miyaki

Bristol-Myers Squibb

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Nobuaki Naruse

Bristol-Myers Squibb

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Hiroshi Kawaguchi

Bristol-Myers Squibb

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Koji Tomita

Bristol-Myers Squibb

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Masahisa Oka

Bristol-Myers Squibb

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Hideo Kamei

Bristol-Myers Squibb

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Kimio Kawano

Bristol-Myers Squibb

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Mitsuaki Tsunakawa

Bristol-Myers Squibb

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