Is this you? Create Your Porfile
Avatar

Kiran Sahasrabudhe

Celgene

Network

Latest external collaboration on country level. Dive into details by clicking on the dots.

Explore More

Hotspot

Dive into the research topics where Kiran Sahasrabudhe is active.

Explore More

Publication

Featured researches published by Kiran Sahasrabudhe.

Bioorganic & Medicinal Chemistry Letters | 2012

Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury.

Véronique Plantevin Krenitsky; Mercedes Delgado; Lisa Nadolny; Kiran Sahasrabudhe; Leticia Ayala; Steven S. Clareen; Robert Hilgraf; Ronald J. Albers; Adam Kois; Kevin S. Hughes; Jonathan Wright; Jacek Nowakowski; Elise A. Sudbeck; Sutapa Ghosh; Sogole Bahmanyar; Philip Chamberlain; Jeff Muir; Brian E. Cathers; David Giegel; Li Xu; Maria Celeridad; Mehran F. Moghaddam; Oleg Khatsenko; Paul Omholt; Jason Katz; Sema Pai; Rachel Fan; Yang Tang; Michael A. Shirley; Brent Benish

In this Letter we describe the optimization of an aminopurine lead (1) with modest potency and poor overall kinase selectivity which led to the identification of a series of potent, selective JNK inhibitors. Improvement in kinase selectivity was enabled by introduction of an aliphatic side chain at the C-2 position. CC-359 (2) was selected as a potential clinical candidate for diseases manifested by ischemia reperfusion injury.

Archive | 2001

Indazole derivatives as JNK inhibitors and compositions and methods related thereto

Shripad S. Bhagwat; Yoshitaka Satoh; Steven T. Sakata; Chris A. Buhr; Ronald J. Albers; John Sapienza; Veronique Plantevin; Qi Chao; Kiran Sahasrabudhe; Rachel Ferri

Archive | 2003

Indazole compounds, compositions thereof and methods of treatment therewith

Shripad S. Bhagwat; Yoshitaka Satoh; Steven T. Sakata; Chris A. Buhr; Ronald J. Albers; John Sapienza; Veronique Plantevin; Qi Chao; Kiran Sahasrabudhe; Rachel Ferri; Rama Krishna Narla

Archive | 2006

Haloaryl substituted aminopurines, compositions thereof,and methods of treatment therewith

Ronald J. Albers; Leticia Ayala; Steven S. Clareen; Maria Mercedes Delgado Mederos; Robert Hilgraf; Sayee G. Hegde; Kevin S. Hughes; Adam Kois; Veronique Plantevin-Krenitsky; Meg Mccarrick; Lisa Nadolny; Moorthy S. S. Palanki; Kiran Sahasrabudhe; John Sapienza; Yoshitaka Satoh; Marianne K. Sloss; Elise A. Sudbeck; Jonathan Wright

Archive | 2004

Indazole compounds and methods of use thereof

Shripad S. Bhagwat; Yoshitaka Satoh; Steven T. Sakata; Chris A. Buhr; Ronald J. Albers; John Sapienza; Veronique Plantevin; Qi Chao; Kiran Sahasrabudhe; Rachel Stengone; Rama Krishna Narla

Archive | 2003

Methods for treating an inflammatory condition or inhibiting JNK

Shripad S. Bhagwat; Yoshitaka Satoh; Steven T. Sakata; Chris A. Buhr; Ronald J. Albers; John Sapienza; Veronique Plantevin; Qi Chao; Kiran Sahasrabudhe; Rachel Ferri

Archive | 2004

Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith

Shripad S. Bhagwat; Yoshitaka Satoh; Steven T. Sakata; Chris A. Buhr; Ronald J. Albers; John Sapienza; Veronique Plantevin; Qi Chao; Kiran Sahasrabudhe; Rachel Ferri

Archive | 2003

Methods of using indazole derivatives as JNK inhibitors

Shripad S. Bhagwat; Yoshitaka Satoh; Steven T. Sakata; Chris A. Buhr; Ronald J. Albers; John Sapienza; Veronique Plantevin; Qi Chao; Kiran Sahasrabudhe; Rachel Ferri

Archive | 2004

Indazole compounds and methods of use thereof as protein kinase inhibitors

Ronald J. Albers; Shripad S. Bhagwat; Chris A. Buhr; Qi Chao; Rama Krishna Narla; Veronique Plantevin; Kiran Sahasrabudhe; Steven T. Sakata; John Sapienza; Yoshitaka Satoh; Rachel Stengone

Archive | 2009

METHODS OF TREATMENT COMPRISING THE ADMINISTRATION OF HALOARYL SUBSTITUTED AMINOPURINES OR COMPOSITIONS THEREOF

Ronald J. Albers; Leticia Ayala; Steven S. Clareen; Maria Mercedes Delgado Mederos; Robert Hilgraf; Sayee G. Hegde; Kevin S. Hughes; Adam Kois; Veronique Plantevin-Krenitsky; Meg Mccarrick; Lisa Nadolny; Moorthy S. S. Palanki; Kiran Sahasrabudhe; John Sapienza; Yoshitaka Satoh; Marianne K. Sloss; Elise A. Sudbeck; Jonathan Wright; Ian Henderson; Andrew G. Cole

Explore More

Collaboration

Dive into the Kiran Sahasrabudhe's collaboration.

Top Co-Authors
Avatar

Ronald J. Albers

Celgene

View shared research outputs
Top Co-Authors
Avatar

John Sapienza

Celgene

View shared research outputs
Top Co-Authors
Avatar

Yoshitaka Satoh

Celgene

View shared research outputs
Top Co-Authors
Avatar

Shripad S. Bhagwat

Celgene

View shared research outputs
Top Co-Authors
Avatar

Adam Kois

Celgene

View shared research outputs
Top Co-Authors
Avatar

Elise A. Sudbeck

Celgene

View shared research outputs
Top Co-Authors
Avatar

Jonathan Wright

Celgene

View shared research outputs
Top Co-Authors
Avatar

Kevin S. Hughes

Harvard University

View shared research outputs
Top Co-Authors
Avatar

Leticia Ayala

Celgene

View shared research outputs
Top Co-Authors
Avatar

Lisa Nadolny

Celgene

View shared research outputs
Explore More
Researchain Logo
Decentralizing Knowledge