Kirk L. Stevens

An expeditious route to CoQn, vitamins K1 and K2, and related allylated para-quinones utilizing Ni(0) catalysis

Abstract Coupling reactions between vinylalanes and chloromethylated para-quinones, mediated by catalytic amounts of Ni(0), lead directly to allylated products, including coenzyme Q, and vitamins K1 and K2.

ALLYLATED AROMATICS VIA NI-CATALYZED COUPLINGS OF BENZYLIC CHLORIDES AND VINYLIC ORGANOMETALLICS

Abstract Hydroalumination and hydrozirconation of alkynes lead to vinylic organometallics which react with benzylic chlorides at room temperature under the influence of in situ-generated, catalytic quantities of (presumably) Ni(0), to afford allylated aromatics in good yields.

Nickel(0)-catalyzed couplings of vinyl- alanes & - zirconocenes with chloromethylated heteroaromatics: A route to E-allylated heterocycles

Abstract Treatment of selected chloromethylated heteroaromatics, including pyridines, thiophenes, and furans, with vinyl alanes or vinyl zirconocenes in the presence of Ni(0) results in E-allylated products in good yields.

Higher order, mixed cyanocuprates derived from N-lithio-imidazole and pyrrole : new dummy ligand alternatives in organocopper chemistry

Abstract Treatment of N-lithioimidazole or N-lithiopyrrole with CuCN followed by an organolithium leads to cuprates R(Imid)Cu(CN)Li 2 and R(Pyrr)Cu(CN)Li 2 which show “higher order” reactivity relative to RCu(CN)Li.

A novel route to the anti-HIV nucleoside d4T

Abstract A novel 2-pot process involving cyclonucleoside formation across C-5′ oxygen in the 2′-deoxyribose and C-6 in the base ultimately leads to the title compound.