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Featured researches published by Kirsty Rickett.


Critical Reviews in Oncology Hematology | 2017

Management of aromatase inhibitor induced musculoskeletal symptoms in postmenopausal early Breast cancer: A systematic review and meta-analysis

Kate Roberts; Kirsty Rickett; Ristan M. Greer; Natasha Woodward

Aromatase Inhibitors (AI) are widely used for the adjuvant treatment of hormone receptor positive breast cancers in the post-menopausal population. AI are often associated with significant joint and muscular symptoms; symptoms that are commonly referred to as aromatase inhibitor-associated musculoskeletal syndrome (AIMSS). AIMSS adversely impacts health-related quality of life of many patients, and reduces AI compliance. Although there are informal practice recommendations, the limited current level of evidence for management of AIMSS for breast cancer patients on aromatase inhibitors has made development of formal guidelines challenging, and remains an unmet need. This is the first systematic review to consider the evidence for all pharmacological and non-pharmacological interventions in the treatment of AIMSS, including physical therapy, acupuncture and complementary therapies.


Journal of Clinical Oncology | 2016

Management of aromatase inhibitor-associated musculoskeletal symptoms: A systematic review.

Kate Roberts; Kirsty Rickett; Natasha Woodward

157 Background: Aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) are experienced by a significant number of women on adjuvant aromatase inhibitors for breast cancer. These symptoms can result in therapy noncompliance and there is no accepted standardised treatment. We believe that this is the first systematic review to consider the evidence for all pharmacological and non-pharmacological interventions in the treatment of AIMSS. METHODS We conducted a systematic search in PubMed, EMBASE, CINAHL and CENTRAL. Clinical trials and observational studies for all potential pharmacological and non-pharmacological interventions were included. Two reviewers screened the results and extracted the relevant data. Risk of bias for the full papers were assessed using JADAD or a modified Newcastle Ottawa score, with conference abstracts and letters to the editor excluded from this process. RESULTS Of 1260 records being identified, 887 unique citations were screened with 93 full text papers retrieved for assessment, and 37 selected for inclusion. We identified 9 pharmacological interventions (RCT = 3, pre-post = 4, cohort = 2) and 28 non-pharmacological interventions (RCT/CCT = 16, pre-post = 8, cohort = 3). The largest number of studies were for various exercise interventions (n = 7) with the largest trial showing a 29% decrease in worst joint pain scores compared to the control (2%, p < 0.001). The highest number of RCTs was for acupuncture (n = 5), the majority of which showed a significant benefit with both real and sham acupuncture. Other single RCTs showing benefit include the use of testosterone, calcitonin and etoricoxib. No study adequately controlled for contamination bias from extraneous variables of both pharmacological and non-pharmacological interventions. CONCLUSIONS Given that pharmacological treatment is often recommended for AIMSS, it is surprising that there is limited published evidence for its use. Although the interventions being used appear tolerable with minimal adverse effects, the current level of evidence is low, and additional large RCTs with more rigorous controlling for contamination from other interventions are required to confirm some of the reported promising results.


Cochrane Database of Systematic Reviews | 2015

Corticosteroids for the management of cancer‐related pain in adults

Alison Haywood; Phillip Good; Sohil Khan; Aurelia Leupp; Sue Jenkins‐Marsh; Kirsty Rickett; Janet Hardy


Critical Reviews in Oncology Hematology | 2016

Mucinous ovarian cancer: a therapeutic review

Wen Xu; Jack Rush; Kirsty Rickett; Jermaine Coward


Cochrane Database of Systematic Reviews | 2018

Exercise therapies for preventing or treating aromatase inhibitor‐induced musculoskeletal symptoms in early breast cancer

Kate Roberts; Kirsty Rickett; Dimitrios Vagenas; Natasha Woodward


Cochrane Database of Systematic Reviews | 2017

Corticosteroids for adult patients with advanced cancer who have nausea and vomiting (not related to chemotherapy, radiotherapy, or surgery)

Petra Vayne-Bossert; Alison Haywood; Phillip Good; Sohil Khan; Kirsty Rickett; Janet Hardy


Cancer Research | 2018

Abstract P3-14-06: The prevention and management of chemotherapy-induced peripheral neuropathy in breast cancer patients: A systematic review

Kate Roberts; S Feng; I. Adsett; Kirsty Rickett; Natasha Woodward


Cochrane Database of Systematic Reviews | 2017

Systemic corticosteroids for the management of cancer-related breathlessness (dyspnoea) in adults

Alison Haywood; Jacqueline Duc; Phillip Good; Sohil Khan; Kirsty Rickett; Petra Vayne-Bossert; Janet Hardy


Cancer Research | 2017

The prevention and management of chemotherapy-induced peripheral neuropathy in breast cancer patients: A systematic review

Kate Roberts; Feng. S.; I. Adsett; Kirsty Rickett; Natasha Woodward


Archive | 2015

Referencing software: funding, future and frameworks

Kirsty Rickett

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Janet Hardy

University of Queensland

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Phillip Good

University of Queensland

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Dimitrios Vagenas

Queensland University of Technology

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Jack Rush

University of Queensland

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