Klaus Michael Stuermer

Estrogen and raloxifene improve metaphyseal fracture healing in the early phase of osteoporosis. A new fracture-healing model at the tibia in rat

BackgroundFracture healing in osteoporosis is delayed. Quality and speed of fracture healing in osteoporotic fractures are crucial with regard to the outcome of patients. The question arises whether established antiosteoporotic drugs can further improve fracture healing.Materials and methodsOsteoporosis manifests predominantly in the metaphyseal bone. Nevertheless, an established metaphyseal fracture model is lacking. A standardized metaphyseal fracture-healing model with stable plate fixation was developed for rat tibiae. The healing process was analyzed by biomechanical, gene expression, and histomorphometric methods in ovariectomized (OVX) and sham-operated rats (SHAM), compared to standardized estrogen (E)- and raloxifene (R)-supplemented diets.ResultsEstrogen and raloxifene improved the biomechanical properties of bone healing compared to OVX (Yield load:

Whole body vibration during fracture healing intensifies the effects of estradiol and raloxifene in estrogen-deficient rats

{\text{SHAM}} = 63.1 \pm 20.8{\text{N}}

Short-Term Effects of Parathyroid Hormone on Rat Lumbar Vertebrae

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Effects of isoflavones equol and genistein on bone quality in a rat osteopenia model.

\operatorname{E} = 60.8 \pm 17.9\operatorname{N}

Equol but not Genistein Improves Early Metaphyseal Fracture Healing in Osteoporotic Rats

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