Klaus Münter
Bayer Corporation
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Klaus Münter.
British Journal of Pharmacology | 2009
Raimund Kast; Hartmut Schirok; Santiago Figueroa‐Pérez; Joachim Mittendorf; Mark Jean Gnoth; H Apeler; J Lenz; J K Franz; Andreas Knorr; Joachim Hütter; Mario Lobell; K Zimmermann; Klaus Münter; K H Augstein; Heimo Ehmke; Johannes Peter Stasch
Rho‐kinase (ROCK) has been implicated in the pathophysiology of altered vasoregulation leading to hypertension. Here we describe the pharmacological characterization of a potent, highly selective and orally active ROCK inhibitor, the derivative of a class of azaindoles, azaindole 1(6‐chloro‐N 4‐{3,5‐difluoro‐4‐[(3‐methyl‐1H‐pyrrolo[2,3‐b]pyridin‐4‐yl)oxy]‐phenyl}pyrimidine‐2,4‐diamine).
ChemMedChem | 2008
Hartmut Schirok; Raimund Kast; Santiago Figueroa‐Pérez; Samir Bennabi; Mark Jean Gnoth; Achim Feurer; Heike Heckroth; Michael Thutewohl; Holger Paulsen; Andreas Knorr; Joachim Hütter; Mario Lobell; Klaus Münter; Volker Geiß; Heimo Ehmke; Dieter Lang; Martin Radtke; Joachim Mittendorf; Johannes-Peter Stasch
Rho kinase plays a pivotal role in several cellular processes such as vasoregulation, making it a suitable target for the treatment of hypertension and related disorders. We discovered a new compound class of Rho kinase (ROCK) inhibitors containing a 7‐azaindole hinge‐binding scaffold tethered to an aminopyrimidine core. Herein we describe the structure–activity relationships elucidated through biochemical and functional assays. The introduction of suitable substituents at the 3‐position of the bicyclic moiety led to an increase in activity, which was required to design compounds with favorable pharmacokinetic profile. Azaindole 32 was identified as a highly selective and orally available ROCK inhibitor able to cause a sustained blood pressure reduction in vivo.
Archive | 2003
Cristina Alonso-Alija; Erwin Bischoff; Klaus Münter; Johannes-Peter Stasch; Elke Stahl; Stefan Weigand; Achim Feurer
Archive | 2004
Samir Bennabi; Heike Heckroth; Hartmut Schirok; Joachim Mittendorf; Raimund Kast; Johannes-Peter Stasch; Mark Jean Gnoth; Klaus Münter; Dieter Lang; Santiago Figueroa Perez; Marcus Bauser; Achim Feurer; Heimo Ehmke
Archive | 2003
Stefan Weigand; Erwin Bischoff; Klaus Münter; Johannes-Peter Stasch; Elke Stahl
Archive | 2003
Michael Härter; Jens Ergüden; Frank Wunder; Hanna Tinel; Johannes Köbberling; Eva-Maria Becker; Klaus Münter; Karl-Heinz Schlemmer; Raimund Kast; Peter Kolkhof; Gunter Karig; Lars Bärfacker; Walter Hübsch; Joachim Schuhmacher; Susanne Zuleger; Arnel Concepcion; Haruka Shimizu
Archive | 2003
Jens-Kerim Ergüden; Peter Kolkhof; Julio C. Castro-Palomino; Alexander Kuhl; Raimund Kast; Johannes-Peter Stasch; Hanna Tinel; Klaus Münter; Klemens Lustig; Josef Pernerstorfer; Martin Bechem; Jörg Hüser
Archive | 2003
Michael Härter; Jens Ergüden; Frank Wunder; Hanna Tinel; Johannes Köbberling; Eva-Maria Becker; Klaus Münter; Karl-Heinz Schlemmer; Raimund Kast; Peter Kolkhof; Gunter Karig; Lars Bärfacker; Walter Hübsch; Joachim Schuhmacher; Susanne Zuleger; Arnel Concepcion; Haruka Shimizu
Archive | 2004
Peter Ellinghaus; Klaus Münter
Archive | 2005
Peter Ellinghaus; Klaus Münter