Korhan Arslan

Expression of Biologically Active Human Interferon Gamma in the Milk of Transgenic Mice Under the Control of the Murine Whey Acidic Protein Gene Promoter

Transgenic animals are used for production of recombinant proteins for scientific, pharmaceutical, and agricultural purposes. The ability of transgenic animals to produce biologically active recombinant proteins in an efficient and economic manner was demonstrated a long time ago and has attracted substantial attention and investments. Human interferon-c (hIFN-c) is a key cytokine endowed with multiple biological activities such as antiviral, antibacterial, antiparasitic, antiproliferative, and immunomodulatory activity (Smith et al. 1990; Tsanev and Ivanov 2001). Human IFN-c is a glycoprotein naturally secreted by activated T lymphocytes and monocytes (Rinderknecht et al. 1984). It is a product of a single gene encoding a protein of 143 amino acids with a molecular mass of 20–25 kDa. The recombinant

Polymorphisms in toll-like receptor (TLR) 1, 4, 9 and SLC11A1 genes and their association with paratuberculosis susceptibility in Holstein and indigenous crossbred cattle in Turkey

Mycobacterium avium subsp. paratuberculosis (MAP) causes major problem in a wide range of animal species. In ruminant livestock including cattle, it causes a chronic disease called Johne’s disease, or paratuberculosis (pTB) which is currently considered as potential zoonosis, causing Crohn’s disease in humans. MAP infection susceptibility is suspected to be controlled by host genetics. Thus, selecting individuals according to their genetic structure could help to obtain bovine populations that are increasingly resistant to MAP infection. The aim of the present work was to investigate the association between toll-like receptor (TLR)

Genotyping of the kappa‐casein and beta‐lactoglobulin genes in Anatolian water buffalo by PCR‐RFLP

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Concentration dependent antioxidative and apoptotic effects of sulforaphane on bovine granulosa cells in vitro

1 (+1380 G/A), TLR1 (+1446 C/A), TLR4 (+10 C/T), TLR9 (+1310 G/A) and solute carrier family 11 member 1 (SLC11A1) (+1066 C/G) mutations and MAP infection status in 813 cattle comprising East Anatolian Red crossbred, Anatolian Black crossbred and Holstein breed. TLR1 (+1380 G/A) mutation showed an association with bovine MAP (

GH-AluI ve MYF5-TaqI Polimorfizmlerinin Erkek Holstein Buzağılarında Sütten Kesim Ağırlığı ve Vücut Ölçüleri Üzerine Etkileri

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High and low protein input in maternal diet alters the expression of genes in fetal skeletal muscle in sheep

P<0.05). For the TLR1 (+1380 G/A) locus, the odds ratio for AG and AA genotypes versus GG genotypes were 2.31 (1.24–4.30; 95% confidence interval (CI)) and 0<0.001 (<0.001 to >999.999; 95% CI) which indicated that a proportion of AG homozygote was significantly higher in pTB-affected animals as compared with the control. General linear model analysis demonstrated higher MAP antibody response in TLR1 (+1380 AG) genotype as compared with TLR1 (+1380 GG) (