Kosei Moriyama
Kyushu University
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Publication
Featured researches published by Kosei Moriyama.
British Journal of Haematology | 1997
Kosei Moriyama; Takashi Okamura; Shuji Nakano
GB virus C (GBV‐C) RNA was detected in five of 18 patients with aplastic anaemia who had received blood transfusions, whereas it was not detected in eight patients who had not received any transfusions. Antibody against hepatitis C virus (anti‐HCV) was detected in nine patients in the transfusion group, compared with one of eight who had not received any transfusions. Therefore, the route of transmission of both GBV‐C and HCV in these patients appeared to have been multiple blood transfusion. Since all of the GBV‐C RNA‐positive patients harboured anti‐HCV, GBV‐C seems to frequently superinfect with HCV. Neither GBV‐C nor HCV is likely to have been a causative agent of the anaemia in the cases examined.
Archives of Virology | 1992
Kosei Moriyama; S. Imayama; Shirou Mohri; T. Kurata; Ryoichi Mori
SummaryThe distribution of HSV-1 during the development of zosteriform skin lesions in SCID mice was analyzed by immunofluorescence and electron microscopy. The virus initially appeared within certain keratinocytes, sometimes surrounded by keratinocytes whose surfaces were also positive for the antigens, in the lower epidermal layers including the hair follicles, and then extended upward to the entire epidermis and downward to the sebaceous glands 1–2 days later, when no macroscopic skin lesion was seen. The affected epidermal cells subsequently degenerated and lost their viral antigens within a day, when the zosteriform lesion then became evident. This was followed by a degeneration of the dermis. The sebaceous glands eventually degenerated in 10 days, but some glands in the necrotic skin areas preferentially retained HSV-1. The horizontal spread of the virus in the epidermis beyond the first invaded dermatome occurred much later. In mice passively immunized with specific immune serum, viral antigens were observed even 20 days after the infection in sebaceous glands in necrotized areas. Therefore, HSV-1 appears to spread first via the extracellular fluid among the keratinocytes after being shed from nerve endings, and then produces a successive degeneration of the affected keratinocytes which may prevent any further extension of horizontal viral spread. The pilosebaceous apparatus is possibly acting as a site not only for the replication of HSV-1 with a delayed cytopathic effect, but also as an area that is temporarily sheltered from host defense mechanisms.
Microbiology and Immunology | 1992
Kosei Moriyama; Shirou Mohri; Takeshi Watanabe; Ryoichi Mori
Some SCID mice survived primary infection with herpes simplex virus 1 without the development of peripheral lesions but established coculture‐positive ganglionic latency when a low dose of a wild‐type strain was inoculated intracutaneously. The latency was also evidenced by the development of the fatal zosteriform skin lesions and the isolation of the virus during pregnancy. We consider that the viral entry into neurons without successive replication, rather than the arrest of the lytic infection within the cells, is an important mechanism in the establishment of latency.
Japanese Journal of Clinical Oncology | 1988
Kosei Moriyama; Hisakazu Muranishi; Junji Nishimura; Kenji Tanaka; Ryohkichi Asayama; Atsushi Takita
Gastroenterology | 1989
Kosei Moriyama; Hiromi Ishibashi; Seizaburo Kashiwagi; Ryohkichi Asayama
The American Journal of Medicine | 1988
Kosei Moriyama; Yoshinobu Asano; Kazuma Fujimoto; Takashi Okamura; Tsunefumi Shibuya; Mine Harada; Yoshiyuki Niho
Japanese Journal of Medicine | 1988
Kosei Moriyama; Masahiko Nozaki; Jiro Kudo; Atsushi Takita; Eiji Tatewaki; Kouichi Yasuda
Japanese Journal of Medicine | 1989
Seiho Nagafuchi; Kosei Moriyama; Yasushi Takamatsu; Shin Hayashi; Yoshiyuki Niho; Akira Takenaka; Hiroko Minagawa; Ryoichi Mori
Japanese Journal of Clinical Oncology | 1989
Tsunefumi Shibuya; Kosei Moriyama; Mine Harada; Takashi Okamura; Shuichi Taniguchi; Koichi Akashi; Ryoichi Mori; Yoshiyuki Niho
中村学園大学・中村学園大学短期大学部研究紀要 = Bulletin of Nakamura Gakuen University and Nakamura Gakuen Junior College | 2015
Sumire Yamaguchi; Nanako Hata; Yuka Ono; Ayumi Shiki; Kayo Yoshimura; Chieko Ito; Junko Ichizu; Toshiko Arima; Yoshiko Miki; Tomie Kajitani; Miyuki Yasumoto; Mihoko Ochi; Tsutomu Kitahara; Kosei Moriyama