Koshirou Hioki

HLA-DR Expression on Cancer Cells and T Cell Reaction in Colorectal Carcinoma

60 cases of colorectal adenocarcinoma were immunohistochemically examined to clarify the relationship between HLA - DR expression on tumor cells and T cell infiltration. The more HLA-DR+ cancer cells in the carcinoma tissue increased, the more T cells tended to aggregate in both the infiltrating front of cancer tissue and the intracarcinomatuos stroma. We speculate that HLA - DR antigen on cancer cells might be immunoreactive and seems to be closely related with the cellular immunity in colorectal carcinoma.

Immunohistochemical Study of the Expression of HLA-DR Antigen and Lymphocyte Infiltration in Human Esophageal Carcinoma

The major histocompatibility complex (MHC) class II antigen HLA-DR is known to be present on many types of immunocompetent cells, involved in a variety of immune functions, and can be found in various kinds of cancer cells of the gastrointestinal tract. It is also reported that HLA-DR is associated with tumor invasion, tumor metastasis, and patient survival [1].