Kothandaraman Shankaran

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Featured researches published by Kothandaraman Shankaran.

Bioorganic & Medicinal Chemistry Letters | 1997

Inhibition of nitric oxide synthase by benzoxazolones

Kothandaraman Shankaran; Karla L. Donnelly; Shrenik K. Shah; John L. Humes; Stephen Pacholok; Stephan K. Grant; Barbara G. Green; Malcolm Maccoss

Abstract A series of benzoxazolones has been synthesized using modifications of literature methods. The synthetic benzoxazolone analogs, along with commercially available analogs, were evaluated as inhibitors of nitric oxide synthases (NOS). Structure-activity relationships are also discussed.

Bioorganic & Medicinal Chemistry Letters | 1994

Preparation and activities of 4″-epi and 4″-deoxy-4″-amino analogs derived from 9-deoxo-8a-aza-8a-homoerythromycin A☆

Kothandaraman Shankaran; Robert R. Wilkening; Timothy A. Blizzard; Ronald W. Ratcliffe; James V. Heck; Amy C. Graham; Charmaine M. Herbert

Abstract The preparation and biological activity of the novel aza macrolides 6, 8, 11–13 and 15–20 are reported. These analogs display in vitro antibacterial properties that are superior to erythromycin A.

Archive | 1995

Cyclic amidine analogs as inhibitors of nitric oxide synthase

Ravindra N. Guthikonda; Stephan K. Grant; Malcolm Maccoss; Shrenik K. Shah; Kothandaraman Shankaran; Charles G. Caldwell; Philippe L. Durette

Archive | 1996

Hexahydro-5-imino-1,4-1,4-thiazepine derivatives as inhibitors of nitric oxide synthases

Charles G. Caldwell; Malcolm Maccoss; William K. Hagmann; Shrenik K. Shah; Kothandaraman Shankaran; Karla L. Furman

Archive | 1995

Substituted heterocycles as inhibitors of nitric oxide synthase

Shrenik K. Shah; Stephan K. Grant; Malcolm Maccoss; Kothandaraman Shankaran; Hongbo Qi; Ravindra N. Guthikonda

Archive | 1992

9-Deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and 8a-positions

James V. Heck; William J. Leanza; Ronald W. Ratcliffe; Thomas N. Salzmann; Robert R. Wilkening; Michael J. Szymonifka; Kothandaraman Shankaran

Bioorganic & Medicinal Chemistry Letters | 2004

Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase.

Kothandaraman Shankaran; Karla L. Donnelly; Shrenik K. Shah; Ravindra N. Guthikonda; Malcolm Maccoss; John L. Humes; Stephen Pacholok; Stephan K. Grant; Theresa M. Kelly; Kenny K. Wong

Bioorganic & Medicinal Chemistry Letters | 2004

Syntheses and SAR studies of 4-(heteroarylpiperdin-1-yl-methyl)-pyrrolidin-1-yl-acetic acid antagonists of the human CCR5 chemokine receptor.

Kothandaraman Shankaran; Karla L. Donnelly; Shrenik K. Shah; Ravindra N. Guthikonda; Malcolm Maccoss; Sander G. Mills; Sandra L. Gould; Lorraine Malkowitz; Salvatore J. Siciliano; Martin S. Springer; Anthony Carella; Gwen Carver; Daria J. Hazuda; Karen Holmes; Joseph Kessler; Janet Lineberger; Michael D. Miller; Emilio A. Emini; William A. Schleif

Bioorganic & Medicinal Chemistry Letters | 2004

Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases.

Kothandaraman Shankaran; Karla L. Donnelly; Shrenik K. Shah; Charles G. Caldwell; Ping Chen; William K. Hagmann; Malcolm Maccoss; John L. Humes; Stephen Pacholok; Theresa M. Kelly; Stephan K. Grant; Kenny K. Wong

Archive | 2003