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Kouta Masutani

Merck & Co.

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Publication

Featured researches published by Kouta Masutani.

Bioorganic & Medicinal Chemistry Letters | 2009

Discovery of novel diarylketoxime derivatives as selective and orally active melanin-concentrating hormone 1 receptor antagonists

Takao Suzuki; Minoru Kameda; Makoto Ando; Hiroshi Miyazoe; Etsuko Sekino; Satoru Ito; Kouta Masutani; Kaori Kamijo; Akihiro Takezawa; Minoru Moriya; Masahiko Ito; Junko Ito; Kazuho Nakase; Hiroko Matsushita; Akane Ishihara; Norihiro Takenaga; Shigeru Tokita; Akio Kanatani; Nagaaki Sato; Takehiro Fukami

Optimization of the lead 2a led to the identification of a novel diarylketoxime class of melanin-concentrating hormone 1 receptor (MCH-1R) antagonists. Our focus was directed toward improvement of hERG activity and metabolic stability. The representative derivative 4b showed potent and dose-dependent body weight reduction in diet-induced obese (DIO) C57BL/6J mice after oral administration. The synthesis and structure-activity relationships of the novel diarylketoxime MCH-1R antagonists are described.

Bioorganic & Medicinal Chemistry Letters | 2006

Structure-based drug design of a highly potent CDK1,2,4,6 inhibitor with novel macrocyclic quinoxalin-2-one structure

Nobuhiko Kawanishi; Tetsuya Sugimoto; Jun Shibata; Kaori Nakamura; Kouta Masutani; Mari Ikuta; Hiroshi Hirai

Archive | 2003

Novel quinoxaline derivatives

Hiroshi Hirai; Nobuhiko Kawanishi; Masaaki Hirose; Tetsuya Sugimoto; Kaori Kamijyo; Jun Shibata; Kouta Masutani

Archive | 2009

Spirodiamine-diarylketoxime derivative

Makoto Ando; 誠 安東; Etsuko Hirose; 江都子 廣瀬; Kouta Masutani; 浩太 桝谷; Minoru Moriya; 守谷 実; Takao Suzuki; 鈴木 隆雄

Archive | 2009

SPIRODIAMINE-DIARYL KETOXIME DERIVATIVE

Makoto Ando; Etsuki Hirose; Kouta Masutani; Minoru Moriya; Takao Suzuki

Archive | 2003

Novel quinoxalinone derivatives

Hiroshi Hirai; Nobuhiko Kawanishi; Masaaki Hirose; Tetsuya Sugimoto; Kaori Kamijyo; Jun Shibata; Kouta Masutani

Archive | 2014

AROMATIC HETEROCYCLIC COMPOUND, MANUFACTURING METHOD THEREOF, ORGANIC SEMICONDUCTOR MATERIAL, AND ORGANIC SEMICONDUCTOR DEVICE

Atsushi Kawada; Takuo Nagahama; Hiroyuki Hayashida; Kouta Masutani

Archive | 2014

Matériau semi-conducteur organique pour transistor organique, et élément de transistor organique

Atsushi Kawada; 川田 敦志; Takuo Nagahama; 拓男 長浜; Hiroyuki Hayashida; 広幸 林田; Kouta Masutani; 浩太 桝谷

Archive | 2009

Spirodiamine-diaryl ketoxime derivative technical field

Makoto Ando; Etsuko Hirose; Kouta Masutani; Minoru Moriya; Takao Suzuki

Archive | 2009

Dérivé de spirodiamine-diarylcétoxime

Makoto Ando; 誠 安東; Etsuko Hirose; 江都子 廣瀬; Kouta Masutani; 浩太 桝谷; Minoru Moriya; 守谷 実; Takao Suzuki; 鈴木 隆雄

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Makoto Ando

Merck

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Minoru Moriya

Merck

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Takao Suzuki

Merck

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Nobuhiko Kawanishi

Merck

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Hiroshi Hirai

Merck

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Jun Shibata

Merck

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Tetsuya Sugimoto

Merck

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Akane Ishihara

Merck

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Akihiro Takezawa

Merck

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Akio Kanatani

Merck

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