Krishna Murthi
GPC Biotech
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Publication
Featured researches published by Krishna Murthi.
Bioorganic & Medicinal Chemistry Letters | 2000
Krishna Murthi; Marja M. Dubay; Christopher McClure; Leonardo Brizuela; Michael Boisclair; Peter J. Worland; Muzammil M. Mansuri; Kollol Pal
Cyclin dependent kinases (CDKs) along with the complementary cyclins form key regulatory checkpoint controls on the cell cycle. Flavopiridol is a synthetic flavone that shows potent and selective cyclin-dependent kinase inhibitory activity. In this paper, we report modifications of the 3-hydroxy-1-methylpiperidinyl (D ring) of flavopiridol and their effect on CDK inhibitory activity.
Bioorganic & Medicinal Chemistry Letters | 2003
Krishna Murthi; Susan E. Smith; Arthur F. Kluge; Gustave Bergnes; Patrick Bureau; Vivian Berlin
An alanine conjugate of a Candida albicans geranylgeranyl transferase I inhibitor was synthesized to facilitate its uptake into the fungal cell. The antifungal activity of CaGGTase-Ala conjugate is demonstrated. It is also shown that the CaGGTase-Ala conjugate affects prenylation of endogenous Rho1p, but has no effect on prenylation of endogenous Ras1p.
Chemistry & Biology | 2004
Frank Becker; Krishna Murthi; Chase Smith; Jon Come; Nuria Costa-Roldán; Christine Kaufmann; Urs Hanke; Carsten Degenhart; Sabine Baumann; Wolfgang Wallner; Andrea Huber; Severine Dedier; Simone Dill; David Kinsman; Mark Hediger; Nicholas Bockovich; Sebastian Meier-Ewert; Arthur F. Kluge; Nikolai Kley
Chemicke Listy | 1995
Muzammil M. Mansuri; Krishna Murthi; Kollol Pal
Chemistry & Biology | 2006
Maureen Caligiuri; Lisa Molz; Qing Liu; Faith Kaplan; Jimmy P. Xu; Jiangwen Z. Majeti; Rebeca Ramos-Kelsey; Krishna Murthi; Sam Lievens; Jan Tavernier; Nikolai Kley
Chemistry & Biology | 2005
Maureen Caligiuri; Frank Becker; Krishna Murthi; Faith Kaplan; Severine Dedier; Christine Kaufmann; Andy Machl; Gabriele Zybarth; Judson Richard; Nick Bockovich; Art Kluge; Nikolai Kley
Archive | 1998
Gustave Bergnes; Vivian Berlin; Jon Come; Arthur F. Kluge; Krishna Murthi; Kollol Pal
Archive | 2005
Maureen Caligiuri; Nikolai Kley; Krishna Murthi
Archive | 2007
Krishna Murthi; Rebecca Casaubon; Arthur F. Kluge; Chase Smith; Joachim Dr. Vogt
Archive | 2007
Krishna Murthi; Roland Köstler; Chase Smith; Tilman Brandstetter; Arthur F. Kluge
