Kristen M. Leraas
Nationwide Children's Hospital
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Publication
Featured researches published by Kristen M. Leraas.
Experimental and Clinical Psychopharmacology | 2009
Sherecce Fields; Christine Collins; Kristen M. Leraas; Brady Reynolds
Robust associations have been identified between impulsive personality characteristics and cigarette smoking during adolescents, indicating that impulsive behavior may play an important role in the initiation of cigarette smoking. The present study extended this research by using laboratory behavioral assessments to explore relationships between three specific dimensions of impulsive behavior (impulsive decision-making, inattention, and disinhibition) and adolescent cigarette smoking. Participants were male and female adolescent smokers (n = 50) and nonsmokers (n = 50). Adolescent smokers were more impulsive on a measure of decision-making; however, there were significant smoking status by gender interaction effects for impulsive inattention and disinhibition. Male smokers were most impulsive on the measure of inattention, but male smokers were least impulsive on the measure of disinhibition. Correlations between biomarkers of smoking and impulsive inattention and disinhibition were found for females but not males. The current findings, coupled with previous findings (Reynolds et al., 2007), indicate there may be robust gender difference in associations between certain types of impulsive behavior and cigarette smoking during adolescence.
Drug and Alcohol Dependence | 2009
Brady Reynolds; Kristen M. Leraas; Christine Collins; Shane Melanko
This research compared delay discounting in mothers and their children (12 or 13 years of age). Half of the mothers (n=15) were current smokers, and the other half (n=15) reported never smoking. Considerable research has shown that adult smokers discount more by delay than nonsmokers, and that parent smoking is a risk factor for adolescent smoking. Thus, it was hypothesized that the mothers who smoked would discount more by delay than the mothers who had never smoked. Also, it was expected that children at increased risk for smoking (i.e., mother is smoker) would discount more by delay than children at lower risk for smoking (i.e., mother is nonsmoker). The results confirmed these hypotheses: mothers who smoked discounted significantly more than nonsmoking mothers; and, in a parallel fashion, children with mothers who smoked discounted significantly more than children of nonsmokers. These findings indicate that delay discounting may be a behavioral risk factor for adolescent cigarette smoking that predates any substantial use of nicotine.
Behavioural Pharmacology | 2009
Sherecce Fields; Kristen M. Leraas; Christine Collins; Brady Reynolds
There has been a wealth of research providing evidence for the relationship between stress and cigarette smoking during adolescence. Despite this knowledge, little is known about possible behavioral mechanisms by which stress exerts its influence on the decision to smoke. This study sought to examine one such behavioral characteristic, delay discounting, that may mediate the relationship between stress and cigarette smoking. Delay discounting generally refers to the discounting of value for outcomes because they are delayed; and high rates of delay discounting have been linked to impulsive behavior. For the current research, adolescent smokers (n = 50) and nonsmokers (n = 50) were compared using a self-report measure of perceived stress and a laboratory assessment of delay discounting. Smokers tended to report higher levels of stress and to discount more by delay, and there was a significant association between reported stress and delay discounting. In addition, delay discounting mediated the relationship between stress and cigarette smoking status. These results suggest that discounting by delay may be a behavior through which stress exerts influence on an adolescents decision to smoke.
Experimental and Clinical Psychopharmacology | 2009
Shane Melanko; Kristen M. Leraas; Christine Collins; Sherecce Fields; Brady Reynolds
This research compared impulsive behavior in adolescent nonsmokers with low ratings of psychopathy (n = 25) and daily smokers with low (n = 25) and high (n = 25) ratings of psychopathy. Assessments of impulsive behavior included question-based and real-time measures of delay discounting and a self report assessment of impulsivity (Barratt Impulsiveness Scale-Adolescent). Smokers with low psychopathy ratings discounted more by delay (i.e., more impulsively) than nonsmokers on both assessments of discounting; however, smokers with high psychopathy ratings did not differ from nonsmokers on either measure. Inversely, from the self report assessment of impulsivity, smokers with low psychopathy ratings did not differ from nonsmokers, but smokers with high psychopathy ratings were more impulsive than nonsmokers. These findings indicate that delay discounting and self reported impulsivity relate differently to characteristics of psychopathy in adolescent nonsmokers and smokers. Also, these findings demonstrate that there are definable subgroups of smokers for whom the frequently observed relationship between cigarette smoking and delay discounting does not apply.
Journal of Applied Behavior Analysis | 2008
Brady Reynolds; Jesse Dallery; Palak Shroff; Michele Patak; Kristen M. Leraas
Cancer Discovery | 2018
Julija Hmeljak; Francisco Sanchez-Vega; Katherine A. Hoadley; Juliann Shih; Chip Stewart; David I. Heiman; Patrick Tarpey; Ludmila Danilova; Esther Drill; Ewan A. Gibb; Reanne Bowlby; Rupa S. Kanchi; Hatice U. Osmanbeyoglu; Yoshitaka Sekido; Jumpei Takeshita; Yulia Newton; Kiley Graim; Manaswi Gupta; Lixia Diao; David L Gibbs; Vesteinn Thorsson; Lisa Iype; Havish S. Kantheti; David T Severson; Gloria Ravegnini; Patrice Desmeules; Achim A. Jungbluth; William D. Travis; Sanja Dacic; Lucian R. Chirieac