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Dive into the research topics where Kristen M. Young is active.

Publication


Featured researches published by Kristen M. Young.


Allergy | 2013

PI3K, ERK, p38 MAPK and integrins regulate CCR3-mediated secretion of mouse and human eosinophil-associated RNases

Revital Shamri; Kristen M. Young; Peter F. Weller

Eosinophils have the capacity to secrete varied cytotoxic proteins. Among the proteins are the eosinophil‐associated RNases (EARs): the human eosinophil‐derived neurotoxin and eosinophilic cationic protein, and their murine ortholog EARs, which have been shown to be involved in host defense, tissue remodeling, and immunity regulation. However, the signal transduction that regulates EARs secretion in response to physiological stimuli, such as chemokines, has been little studied in human and scarcely in mouse eosinophils, the foremost animal model for eosinophil‐associated human diseases.


Clinical & Experimental Allergy | 2018

Rho and Rac, but not ROCK, are required for secretion of human and mouse eosinophil-associated RNases

Revital Shamri; Kristen M. Young; Peter F. Weller

Eosinophil‐associated RNases (EARs) are stored preformed in eosinophil cytoplasmic secretory granules and have a key role in eosinophil effector functions in host defence and inflammatory disorders. However, the secretion mechanisms of EARs are poorly understood.


Archive | 2015

sustained isocapnic hypoxia in adult humans breathing on ventilatory response to 2 Effect of prior O

T. Kuriyama; H. Tani; A. Masuda; Toshio Kobayashi; H. Kimura; S. Masuyama; Ryan W. Bavis; Gordon S. Mitchell; Fabiola León-Velarde; Alfredo Gamboa; Maria Rivera-Ch; Jose-Antonio Palacios; A Peter; Kristen M. Young; Kevin J. Barry; Matthew R. Boller; Eugene Kim; M Peter


Archive | 2015

sensitive period normoxia and acute hypoxia in rats: implication for a Postnatal development of metabolic rate during

Qiuli Liu; Charles Fehring; T. F. Lowry; Margaret T. T. Wong-Riley; Alida R. Ovrutsky; Donna A. Rampersad; Ryan W. Bavis; Kristen M. Young; Kevin J. Barry; Matthew R. Boller; Eugene Kim; Catherine A. Mayer; J. M. Di Fiore; Richard J. Martin; Peter M. MacFarlane; Jianguo Zhuang; Lei Zhao; Fadi Xu


Archive | 2015

eupneic ventilation in the intact, unanesthetized dog Contribution of the carotid body chemoreceptors to

Gregory M. Blain; Curtis A. Smith; Kathleen S. Henderson; A Jerome; Ryan W. Bavis; Kristen M. Young; Kevin J. Barry; Matthew R. Boller; Eugene Kim; M Peter; Christo Goridis; Pierre-Louis Ruffault; Boris Matrot; Gilles Fortin; Jean-François Brunet; Marie-Rose Hirsch; Muriel Thoby-Brisson; Véronique Dubreuil; Jerome A. Dempsey


Journal of Immunology | 2012

p38 MAPK but not ERK is required for eosinophil migration and degranulation

Revital Shamri; Kristen M. Young; Peter F. Weller


The Journal of Allergy and Clinical Immunology | 2011

Inhibition of Notch Signaling Delays GM-CSF Induced ERK Pathway Activation in Human Eosinophils

Jason J. Xenakis; Amy L. Radke; Kristen M. Young; Rossana C. N. Melo; Lisa A. Spencer


Journal of Immunology | 2011

Cytoskeletal and microtubule machineries in concert with integrins are required for the secretion of eosinophil-associated RNases

Revital Shamri; Kristen M. Young; Rossana C. N. Melo; Ionita Ghiran; Peter F. Weller


The FASEB Journal | 2010

Hypoxic ventilatory responses of rats and mice after perinatal hyperoxia: does the level of hypoxia matter?

Ryan W. Bavis; Elizabeth F. Dmitrieff; Kristen M. Young; Samantha E. Piro


The FASEB Journal | 2009

Exercise performance in moderate hypoxia in rats with impaired carotid bodies

Kristen A Meyers; Kristen M. Young; Ryan W. Bavis

Collaboration


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Peter F. Weller

Beth Israel Deaconess Medical Center

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Revital Shamri

Weizmann Institute of Science

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Revital Shamri

Weizmann Institute of Science

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Rossana C. N. Melo

Universidade Federal de Juiz de Fora

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Amy L. Radke

Beth Israel Deaconess Medical Center

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Catherine A. Mayer

Case Western Reserve University

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Curtis A. Smith

University of Wisconsin-Madison

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