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Dive into the research topics where Kshama Devi is active.

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Featured researches published by Kshama Devi.


Aaps Pharmscitech | 2009

Effect of Cyclodextrin Complexation of Curcumin on its Solubility and Antiangiogenic and Anti-inflammatory Activity in Rat Colitis Model

Vivek R. Yadav; Sarasija Suresh; Kshama Devi; Seema Yadav

The purpose of the study was to prepare and evaluate the anti-inflammatory activity of cyclodextrin (CD) complex of curcumin for the treatment of inflammatory bowel disease (IBD) in colitis-induced rat model. Inclusion complexes of curcumin were prepared by common solvent and kneading methods. These complexes were further evaluated for increase in solubility of poorly soluble curcumin. The inclusion complexes were characterized for enhancement in solubility, in vitro dissolution, surface morphology, infrared, differential scanning calorimetry, and X-ray studies. Solubility, phase solubility, and in vitro dissolution studies showed that curcumin has higher affinity for hydroxypropyl-β-CD (HPβCD) than other CDs. HPβCD complex of curcumin was further investigated for its antiangiogenic and anti-inflammatory activity using chick embryo and rat colitis model. HPβCD complex of curcumin proved to be a potent angioinhibitory compound, as demonstrated by inhibition of angiogenesis in chorioallantoic membrane assay. Curcumin- and HPβCD-treated rats showed a faster weight gain compared to dextran sulfate solution (DSS) controls. Whole colon length appeared to be significantly longer in HPβCD-treated rats than pure curcumin and DSS controls. An additional finding in the DSS-treated rats was the predominance of eosinophils in the chronic cell infiltrate. Decreased mast cell numbers in the mucosa of the colon of CD of curcumin- and pure-curcumin-treated rats was observed. This study concluded that the degree of colitis caused by administration of DSS was significantly attenuated by CD of curcumin. Being a nontoxic natural dietary product, curcumin could be useful in the therapeutic strategy for IBD patients.


Journal of Pharmacy and Pharmacology | 2009

Novel formulation of solid lipid microparticles of curcumin for anti-angiogenic and anti-inflammatory activity for optimization of therapy of inflammatory bowel disease

Vivek R. Yadav; Sarasija Suresh; Kshama Devi; Seema Yadav

Objectives This project was undertaken with a view to optimize the treatment of inflammatory bowel disease through a novel drug delivery approach for localized treatment in the colon. Curcumin has poor aqueous solubility, poor stability in the gastrointestinal tract and poor bioavailability. The purpose of the study was to prepare and evaluate the anti‐inflammatory activity of solid lipid microparticles (SLMs) of curcumin for the treatment of inflammatory bowel disease in a colitis‐induced rat model by a colon‐specific delivery approach.


Lung India | 2015

A novel approach for lung delivery of rifampicin-loaded liposomes in dry powder form for the treatment of tuberculosis

JagadevappaS Patil; VKusum Devi; Kshama Devi; S Sarasija

Background: Lung administration of antibiotics by nebulization is promising for improved treatment efficiency for pulmonary infections, as it increases drug concentration at sites of infection while minimizing systemic side effects. For poorly soluble molecules like rifampicin, lipid particulate system may improve lung delivery. Materials and Methods: We investigated rifampicin-loaded freeze-dried liposomes. Various formulations were prepared with different drug lipid ratios and one formulation was optimized. Optimized colloidal liposome formulation was freeze-dried and subsequently subjected for various evaluation and characterization parameters such as in-vitro dissolution, in-vitro antitubercular activity, aerodynamic characters, surface morphology, and thermal behavior. The optimized formulation of rifampicin-loaded freeze-dried liposome and free rifampicin was subjected for the in-vivo drug disposition study in Wister rat model by intra-tracheal instillation in comparison with an oral route of administration. Results: The results of pharmacokinetic study for both free drug and the formulation suggested that liposomes released the drug in a controlled manner for a longer period of time. The enhanced efficiency of drug incorporated into liposomes suggested that the delivery of encapsulated drugs to macrophages was more rapid than that of free drug. Conclusion: Therefore, the pharmacokinetic and drug disposition studies provided a sound basis for predicting the successful treatment for tuberculosis.


Journal of Young Pharmacists | 2011

Preparation and Characterization of Pioglitazone Cyclodextrin Inclusion Complexes

Pandit; Gorantla R; Kshama Devi; Roopa S. Pai; Sarasija S

Pioglitazone, a class II Biopharmaceutical Classification System drug having poor water solubility and slow dissolution rate may have a negative impact on its subtherapeutic plasma drug levels leading to therapeutic failure. In order to improve its water solubility and thus dissolution, cyclodextrin complexation technique was followed. The phase solubility studies were carried using three different types of cyclodextrins viz., β, methyl-β and γ-cyclodextrins. The Gibbs free energy was calculated in order to determine ease of the complexation. Binary systems of pioglitazone with cyclodextrins were prepared by kneading method and spray drying method. The phase solubility profiles with all the three cyclodextrins were classified as A L -type, indicating the formation of 1:1 stoichiometric inclusion complexes. The complexation capability of cyclodextrins with pioglitazone increased in the order of methyl-β > β > γ-cyclodextrin. The Gibbs free energy was found to be in the order γ > methyl-β > β cyclodextrin. Characterization of inclusion complexes was done by solubility studies, in vitro dissolution studies, Fourier transformation-infrared spectroscopy, scanning electron microscopy, differential scanning calorimetry and X-ray powder diffractometry studies. Inclusion complexes exhibited higher rates of dissolution than the corresponding physical mixtures and pure drug. Greater solubility was observed with spray-dried methyl-β cyclodextrin complexes (2.29 ± 0.001 mg/ml) in comparison to the kneaded methyl-β cyclodextrin complexes (1.584 ± 0.053 mg/ml) and pure drug (0.0714 ± 0.0018 mg/ml).


Indian Journal of Pharmacology | 2010

Effect of saturated fatty acid-rich dietary vegetable oils on lipid profile, antioxidant enzymes and glucose tolerance in diabetic rats

Benson Mathai Kochikuzhyil; Kshama Devi; Santosh R Fattepur

Objective: To study the effect of saturated fatty acid (SFA)-rich dietary vegetable oils on the lipid profile, endogenous antioxidant enzymes and glucose tolerance in type 2 diabetic rats. Materials and Methods: Type 2 diabetes was induced by administering streptozotocin (90 mg/kg, i.p.) in neonatal rats. Twenty-eight-day-old normal (N) and diabetic (D) male Wistar rats were fed for 45 days with a fat-enriched special diet (10%) prepared with coconut oil (CO) – lauric acid-rich SFA, palm oil (PO) – palmitic acid-rich SFA and groundnut oil (GNO) – control (N and D). Lipid profile, endogenous antioxidant enzymes and oral glucose tolerance tests were monitored. Results: D rats fed with CO (D + CO) exhibited a significant decrease in the total cholesterol and non-high-density lipoprotein cholesterol. Besides, they also showed a trend toward improving antioxidant enzymes and glucose tolerance as compared to the D + GNO group, whereas D + PO treatment aggravated the dyslipidemic condition while causing a significant decrease in the superoxide dismutase levels when compared to N rats fed with GNO (N + GNO). D + PO treatment also impaired the glucose tolerance when compared to N + GNO and D + GNO. Conclusion: The type of FA in the dietary oil determines its deleterious or beneficial effects. Lauric acid present in CO may protect against diabetes-induced dyslipidemia.


Journal of Pharmacology and Pharmacotherapeutics | 2010

Protective role of glibenclamide against nicotinamide-streptozotocin induced nuclear damage in diabetic Wistar rats

Syed Imam Rabbani; Kshama Devi; Salma Khanam

Objective: To evaluate the protective effect of glibenclamide against the experimental diabetes-induced nuclear damage in Wistar rats. Materials and Methods: The anti-mutagenic effect of glibenclamide (0.5, 5 and 50 mg/kg, p.o daily for 4 weeks) was evaluated against the nicotinamide (NA)-streptozotocin (STZ) induced type-2 diabetes mellitus using bone marrow micronucleus and sperm abnormalities tests. The antioxidant status was tested by estimating the serum levels of lipid peroxidation (LPO), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx). Results: The results indicated that glibenclamide at 50 mg/kg decreased the frequency of micronuclei in erythrocytes (P < 0.05) and sperm shape abnormality (P < 0.01) besides enhancing the antioxidant status (P < 0.05) in the diabetic rats. However, glibenclamide treatment did not enhance the polychromatic and normochromatic erythrocytes (P/N) ratio and sperm count in the diabetic condition. Conclusion: The observations indicate that the glibenclamide has anti-mutagenic potential which could be related to the antioxidant effect and might also possess anti-proliferative property.


Drug Development and Industrial Pharmacy | 2013

Pharmacokinetic and pharmacodynamic evaluation of floating microspheres of metformin hydrochloride

Vinay Pandit; Roopa S. Pai; Vivek R. Yadav; Kshama Devi; B. B. Surekha; Mohd N. Inamdar; Sarasija Suresh

Metformin hydrochloride (MH), a biguanide antidiabetic, is the drug of choice in obese patients. It is well absorbed from the upper part of gastrointestinal tract and has oral bioavailability of 50% to 60%. The objective of this study was to formulate MH into floating microspheres in order to increase its residence time at the site of absorption and thus improve its bioavailability; and to extend the duration of action along with possibilities of dose reduction. Microspheres were prepared by emulsion solvent evaporation method and evaluated for particle size, entrapment efficiency, buoyancy, and in vitro release; and further characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, and differential scanning calorimetry. The pharmacokinetic and pharmacodynamic evaluation of selected formulation was carried out in male Wistar diabetic rats. The data was statistically analyzed by unpaired t-test. A 3.5-fold increase in relative bioavailability was observed. The prolongation of half-life (t1/2) from 4.5 ± 2.41 h to 14.12 ± 4.81 h indicated extended duration of action. Oral glucose tolerance test (OGTT) was analyzed by one-way analysis of variance followed by Dunnet multiple comparison test, a significant decrease (p < 0.05) in the blood glucose levels was observed when formulations were compared with control rats. Hence, MH floating microspheres were tested at 50 mg/kg and 100 mg/kg body weight, OGTT data showed nonsignificant difference (p >0.05). In conclusion, an effective oral antidiabetics treatment can be achieved by formulating MH into floating microspheres which results in increase in bioavailability along with extended duration of action resulting in possible reduction in dose.


Natural Product Research | 2007

Isolation and characterisation of bioactive isoflavonoids from the roots of Dalbergia horrida

Manoj C. Narayanan; Priya R. Rao; Nagarajan N. Shanmugam; Sethuraman M. Gopalakrishnan; Kshama Devi

The roots of Dalbergia horrida yielded two new isoflavanones, Dalhorridin (I) – 5,5′-dihydroxy-3′,4′-methylenedioxy-5″-prenyl-6″,6″-dimethyl-dihydropyrano(2″,3″ : 7,8)-isoflavanone and Dalhorridinin (II) – 5,7,5′-trihydroxy-3′,4′-methylenedioxy-8-[5-methyl-2-(2-hydroxyisopropyl)-1,4-hexadienyl]isoflavanone along with two known isoflavones, Dalspinin and Dalspinosin. Preliminary biological screening of the enriched extract revealed that it showed analgesic, anti-inflammatory, CNS depressant and mild anti-bacterial properties.


Pharmaceutical methods | 2012

Development and validation of the liquid chromatographic method for simultaneous estimation of metformin, pioglitazone, and glimepiride in pharmaceutical dosage forms

Vinay Pandit; Roopa S. Pai; Gurinder Singh; Kshama Devi; Satya Narayana; Sarasija Suresh

Introduction: A simple, precise, and accurate HPLC method for simultaneous estimation of metformin hydrochloride (MET), pioglitazone hydrochloride (PIO), and glimepiride (GLIMP) was developed and validated. Materials and Methods: Chromatographic separation of the drugs was performed by using a Phenomenex-ODS-3 (C-18) column (250 × 4.60 mm, 5 μm) with a mobile phase consisting of methanol:acetonitrile:15 mM potassium dihydrogen phosphate (pH 4) in the proportion of 40:35:25 (v/v) at a flow rate of 1 ml/min. Detection was carried out using a UV-SPD-10AVP detector at 240 nm. Results: The retention time for MET, PIO, and GLIMP were 2.85 ± 0.03 min, 4.52 ± 0.03 min, and 7.08 ± 0.02min, respectively. Parameters such as linearity (0.2–50 μg/ ml for MET, 0.2–30 μg/ml for PIO, and GLIMP, respectively), precision (intra-day % RSD was 1.01–3.24 and inter-day % RSD was 1.54–4.09 for MET; intra-day % RSD was 1.03–2.09 and inter-day % RSD was 2.26–3.10 for PIO; and intra-day% RSD was 1.00–3.15 and inter-day % RSD was 1.58–3.07 for GLIMP), accuracy (99.66 ± 0.14 for MET, 98.46 ± 0.40 for PIO, and 98.62 ± 0.39 for GLIMP), specificity and robustness were calculated in accordance with ICH guidelines. Conclusions: The method was proved to be simple, rapid, precise, accurate, and cost effective.


Clinical Research and Regulatory Affairs | 2008

Novel Self-emulsifying Formulation of Curcumin with Improved Dissolution, Antiangiogenic and Anti-inflammatory Activity

Yadav Vivek Ramshankar; Sarasija Suresh; Kshama Devi

To enhance the dissolution and oral absorption of poorly soluble curcumin, self-emulsifying drug delivery system (SEDDS) was developed. SEDDS is composed of oil, surfactant, and cosurfactant and evaluated for its physicochemical properties, anti-angiogenic and anti-inflammatory activity in colitis induced rat model. SEDDS formulations were characterized for enhancement in solubility, in vitro dissolution, surface morphology, IR, DSC and X-ray studies. Formulation SF-2 had shown maximum solubility and in vitro release. In addition, SF-2 was found to have angio-inhibitory activity, as demonstrated by inhibition of angiogenesis in chorioallantoin membrane assay (CAM). Anti-inflammatory activity was evaluated using DSS induced colitis rat model. Curcumin and SF-2 treated rats showed faster weight gain and the whole colon length appeared to be significantly longer than in pure curcumin and DSS treated controls. An additional finding in the DSS-treated rats was the predominance of eosinophils in the chronic cell infiltrate. Decreased mast cell numbers in the mucosa of the colon of SF-2 and pure curcumin treated rats was observed. This study concluded that the degree of colitis caused by administration of DSS was significantly attenuated by SEDDS formulation (SF-2). Being a nontoxic natural dietary product, curcumin could be useful in the therapeutic strategy for IBD patients.

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Salma Khanam

Al-Ameen College of Pharmacy

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Syed Imam Rabbani

Al-Ameen College of Pharmacy

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Sarasija Suresh

Al-Ameen College of Pharmacy

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Roopa S. Pai

Al-Ameen College of Pharmacy

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Nagaraju M. Patro

Al-Ameen College of Pharmacy

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Vinay Pandit

Al-Ameen College of Pharmacy

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Vivek R. Yadav

Al-Ameen College of Pharmacy

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Arghya Biswas

Al-Ameen College of Pharmacy

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Seema Yadav

Al-Ameen College of Pharmacy

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V. Kusum Devi

Al-Ameen College of Pharmacy

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