Kshitij Chhabilbhai Thakkar
Purdue University
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Publication
Featured researches published by Kshitij Chhabilbhai Thakkar.
Tetrahedron Letters | 1994
Kshitij Chhabilbhai Thakkar; Mark Cushman
Abstract An unusual oxidative cyclization of chalcones by thallium (III) trinitrate (TTN) to 4-methoxyaurones has been studied. A key feature of this reaction is the introduction of a methoxyl group into the aurone skeleton. Several reactions have been performed to understand the mechanism and regiochemistry of cyclization.
Journal of Medicinal Chemistry | 2014
Martha Kelly; Sherrie Lynn Pietranico-Cole; J. Douglas Larigan; Nancy-Ellen Haynes; Charles H. Reynolds; Nathan Robert Scott; John Vermeulen; Mark T. Dvorozniak; Karin Conde-Knape; Kuo-Sen Huang; Sung-Sau So; Kshitij Chhabilbhai Thakkar; Yimin Qian; Bruce L. Banner; Frank Mennona; Sara Danzi; Irwin Klein; Rebecca Taub; Jefferson Wright Tilley
The beneficial effects of thyroid hormone (TH) on lipid levels are primarily due to its action at the thyroid hormone receptor β (THR-β) in the liver, while adverse effects, including cardiac effects, are mediated by thyroid hormone receptor α (THR-α). A pyridazinone series has been identified that is significantly more THR-β selective than earlier analogues. Optimization of this series by the addition of a cyanoazauracil substituent improved both the potency and selectivity and led to MGL-3196 (53), which is 28-fold selective for THR-β over THR-α in a functional assay. Compound 53 showed outstanding safety in a rat heart model and was efficacious in a preclinical model at doses that showed no impact on the central thyroid axis. In reported studies in healthy volunteers, 53 exhibited an excellent safety profile and decreased LDL cholesterol (LDL-C) and triglycerides (TG) at once daily oral doses of 50 mg or higher given for 2 weeks.
Journal of Medicinal Chemistry | 1993
Kshitij Chhabilbhai Thakkar; Robert L. Geahlen; Mark Cushman
Journal of Organic Chemistry | 1995
Kshitij Chhabilbhai Thakkar; Mark Cushman
Archive | 2003
Shaoqing Chen; Wendy Lea Corbett; Kevin Richard Guertin; Nancy-Ellen Haynes; Robert Francis Kester; Francis A. Mennona; Steven Gregory Mischke; Yimin Qian; Ramakanth Sarabu; Nathan Robert Scott; Kshitij Chhabilbhai Thakkar
Archive | 2006
Steven Joseph Berthel; Adrian Wai-Hing Cheung; Kyungjin Kim; Shiming Li; Kshitij Chhabilbhai Thakkar; Weiya Yun
Archive | 2012
Joseph Anthony Bilotta; Adrian Wai-Hing Cheung; Fariborz Firooznia; Kevin Richard Guertin; Stuart Hayden; Nancy-Ellen Haynes; Christine M. Lukacs-Lesburg; Nicholas Marcopulos; Eric Mertz; Lida Qi; Yimin Qian; Sung-Sau So; Jenny Tan; Kshitij Chhabilbhai Thakkar
Archive | 2006
Nancy-Ellen Haynes; Denis John Kertesz; Sherrie Lynn Pietranico-Cole; Yimin Qian; Nathan Robert Scott; Sung-Sau So; Kshitij Chhabilbhai Thakkar; Jefferson Wright Tilley
Archive | 2006
Nancy-Ellen Haynes; Denis John Kertesz; Sherrie Lynn Pietranico-Cole; Yimin Qian; Nathan Robert Scott; Sung-Sau So; Kshitij Chhabilbhai Thakkar; Jefferson Wright Tilley
Archive | 2006
Steven Joseph Berthel; Adrian Wai-Hing Cheung; Kyungjin Kim; Shiming Li; Kshitij Chhabilbhai Thakkar; Weiya Yun