Kumiko Kurabayashi

Gatifloxacin Resistance and Mutations in gyrA after Unsuccessful Helicobacter pylori Eradication in Japan

ABSTRACT A high resistance rate (47.9%) to gatifloxacin (GAT; 8-methoxy fluoroquinolone) in Helicobacter pylori (H. pylori) strains from 48 Japanese patients is observed after unsuccessful H. pylori eradication. A significant association between MICs for GAT equal to or above 1 μg/ml and mutations of the gyrA gene of H. pylori was demonstrated.

Effect of dietary anti-urease immunoglobulin Y on Helicobacter pylori infection in Mongolian gerbils.

Background and aim.  Helicobacter pylori is known to be a major pathogenic factor in the development of gastritis, peptic ulcer disease and gastric cancer. Recently, chicken egg yolk immunoglobulin Y (IgY) has been recognized as an inexpensive antibody source for passive immunization against gastrointestinal infections. The present study was designed to investigate the effect of anti‐urease IgY on H. pylori infection in Mongolian gerbils.

Second-line treatment of Helicobacter pylori infection after dilution agar methods and PCR-RFLP analysis

Background : After unsuccessful first‐line treatment of Helicobacter pylori infection, the percentage of clarithromycin‐resistant strains has been reported as between 30% and 70% in Japan and other countries. A high prevalence of clarithromycin‐resistant strains is reported to be associated with eradication failure.

Could frameshift mutations in the frxA and rdxA genes of Helicobacter pylori be a marker for metronidazole resistance?: FRXA AND RDXA GENES TO METRONIDAZOLE RESISTANCE IN H. PYLORI

Although resistance of Helicobacter pylori to metronidazole had been reported to be associated with mutations in the rdxA or the frxA gene, recent studies have indicated that they may contribute little to metronidazole resistance.