Kuniaki Tatsuta

Total syntheses of de-branched nagstatin and its analogs having glycosidase inhibiting activities

Abstract De-branched nagstatin and its analogs have been synthesized from protected L-ribo- and xylofuranoses through the inter- and intra-molecular nucleophilic reactions with the imidazole moieties.

Synthetic studies on naphthopyrans from a polyketide lactone

Abstract Naphthopyrans, one of which is a synthetic precursor of antifungal semivioxanthin, have been synthesized from a 14-membered polyketide lactose by the intramolecular aldolization.

Synthesis and characterization of a 14-membered polyketide lactone

Abstract A stable 14-membered polyketide lactone having a C-methyl group at C-13 has been synthesized and elucidated to have the bis-enol structure by X-ray crystallographic analysis, and its hydride reduction to the tetraols has also been described.

A practical preparation of (Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic acid

Abstract A Z -isomer of 2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic acid, which is the common acyl moiety of clinically useful cephalosporins, has been prepared from the aminoisoxazols through the thiadiazol-acetate in two pathways.

Enantioselective Synthesis of Pyrizinostatin, a Pyroglutamyl Peptidase Inhibitor

Enantiospecifically pure pyrizinostatin was synthesized from 2-methyl- fervenulone by using chiral imines of acetone

Total synthesis of chlorinated phenylpyrrole antibiotics, (+)- and (−)-neopyrrolomycins

Abstract (+)- and (−)-Neopyrrolomycins have been synthesized from 3,5-dichlorophenol through regioselective halogenations and optical resolution.

A synthesis and structural confirmation of 3,5-bis(2-alkylimidazol-4-yl)-1,2,4-trithiolanes

The structures of the 4-formylimidazole equivalents which were prepared by heating 2-alkyl-4-dithiocarboxylimidazoles with 47% HBr or conc. H 2 SO 4 have been revised to be 3,5-bis(2-alkylimidazol-4-yl)- 1,2,4-trithiolanes by X-ray crystallographic analyses