Shozo Miura

Total syntheses of de-branched nagstatin and its analogs having glycosidase inhibiting activities

Abstract De-branched nagstatin and its analogs have been synthesized from protected L-ribo- and xylofuranoses through the inter- and intra-molecular nucleophilic reactions with the imidazole moieties.

Total synthesis of nagstatin, an N-acetyl-β-D-glucosaminidase inhibitor

Abstract The first enantiospecific total synthesis of nagstatin has been accomplished through the regioselective introduction of an allyl group on the imidazole ring of the de-branched nagstatin precursor followed by conversion into the carboxymethyl group, and the stereospecifc introduction of the acetamido group.

A practical preparation of (Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic acid

Abstract A Z -isomer of 2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic acid, which is the common acyl moiety of clinically useful cephalosporins, has been prepared from the aminoisoxazols through the thiadiazol-acetate in two pathways.

A synthesis and structural confirmation of 3,5-bis(2-alkylimidazol-4-yl)-1,2,4-trithiolanes

The structures of the 4-formylimidazole equivalents which were prepared by heating 2-alkyl-4-dithiocarboxylimidazoles with 47% HBr or conc. H 2 SO 4 have been revised to be 3,5-bis(2-alkylimidazol-4-yl)- 1,2,4-trithiolanes by X-ray crystallographic analyses