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Featured researches published by Kunihiko Mabuchi.


生体医工学 | 2014

A Challenge to Modify Neuronal Activities to Persistently Control a Vehicular BMI RatCar

Osamu Fukayama; Masataka Yokota; Ryosuke Nakanishi; Kunihiko Mabuchi

Instability of neural recordings from the brain is a big problem to develop invasive brainmachine interfaces (BMIs) including our vehicular system for a rat “RatCar”. Its ability to estimate actual locomotion from motor cortical activities has strictly depended on local functionality around the electrodes. It has been almost impossible to select specific neurons to record, and to keep the selection after the implant surgery. Meanwhile, neurons are known to be functionally plastic to change their own behaviour according to synaptic inputs. We have recently started a challenge to induce plastic changes of the motor cortex by applying micro-current stimuli to forcibly correlate their activities with voluntary locomotion. In this work, our methodology and preliminary results are described towards a more persistent controller for BMI systems.


Archive | 2011

Toward the Precise Control of Cell Differentiation Processes by Using Micro and Soft Lithography

Yuzo Takayama; Hiroyuki Moriguchi; Kiyoshi Kotani; Takafumi Suzuki; Kunihiko Mabuchi; Yasuhiko Jimbo

Regeneration of the central nervous system (CNS), where proliferative potency is limited, is one of the most important research themes in neuroscience and neuroengineering. Pluripotent stem cell lines have attracted broad attentions as an important model system for regenerating damaged brain. The important key for realizing regenerative medicine using pluripotent stem cells is to induce undifferentiated cell into objective cells with high efficiency and reproducibility. Although the methods to induce embryonic stem (ES) cells into specific neuronal subtype with pharmacological treatment have been proposed, however, the handling is difficult and thus the efficiency rate of objective cells is low (Barberi et al., 2003). The main reason for low differentiation rate of pluripotent stem cells is difficulty in precise control of interaction between pharmacological treatment and cell signalling. To overcome these problems, development of alternative methods for precise control of cell differentiation processes is required. During cell differentiation, both endogenous factors, such as cell-cell signal transmission, and exogenous factors, such as pharmacological application, play important roles. Micro and soft lithography-based surface modification of culture substrate enabled to control stem-cell-aggregation (EB; Embryoid body) sizes and therefore to increase cell differentiation efficiency through promotion of cell-cell signal interactions (Karp et al., 2007; Wang et al., 2009). Particularly, Park et al. reported that small-size EBs of mouse ES cells (100 ~ 200 m of diameter) tended to differentiate into ectoderm and large-size EB (500 m of diameter) into mesoderm (Park et al., 2007). These reports suggested that manipulation of EB size and shape could affect endogenous factors of stem cell EBs and thus was an important approach for precise control of differentiation processes. Another important technique for regulating cell differentiation is applying physical stimulation. It was reported that electrical or magnetic stimulation could induce cellular and molecular responses and affected the gene expressions during differentiation (Kimura et al., 1998; Piacentini et al., 2008). Particularly, Yamada et al. reported that applying electrical stimulation induced mouse ES cells efficiently into ectoderm cells (Yamada et al., 2007). These reports suggested


IEEE Engineering in Medicine and Biology Magazine | 2002

Human Thermal Models for Evaluating Infrared Images Comparing Infrared Images Under Various Thermal Environmental Conditions Through Normalization of Skin Surface Temperature

Naoto Kakuta; Shintaro Yokoyama; Kunihiko Mabuchi


The Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) | 2016

Development of a Wire Driven Elbow Exercise Device for Upper Limb Rehabilitation

Chengyu Wang; Shintaro Nakatani; Nozomu Araki; Yasuo Konishi; Kunihiko Mabuchi


The Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) | 2016

Rat mountable whole body type animal mimicking robot platform for biological information peripherals

Naoto Konno; Taiki Kudo; Osamu Fukayama; Takeshi Hirano; Kunihiko Mabuchi; Takashi Kei Saito


The Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) | 2015

1P2-K06 Development and Evaluation of Foot Pedaled Exercise Device for Lower Limb Rehabilitation

Ren Ijiri; Shintaro Nakatani; Nozomu Araki; Yasuo Konishi; Kunihiko Mabuchi


Archive | 2015

Forelimb Muscles in Rhesus Macaques Properties of Primary Motor Cortex Output to

Abderraouf Belhaj-Saïf; Paul D. Cheney; Carl W. Luchies; Gustaf M. Van Acker; Sommer L. Amundsen; William G. Messamore; Hongyu Y. Zhang; Heather M. Hudson; Darcy M. Griffin; Kazuhiko Seki; Hiroaki Yaguchi; Tomohiko Takei; David Kowalski; Takafumi Suzuki; Kunihiko Mabuchi


生物物理 | 2014

3P137 電気-機械相互作用を考慮した心筋細胞群モデル(10. 筋肉,ポスター,第52回日本生物物理学会年会(2014年度))

Hiroki Miyazako; Toshiki Murata; Osamu Fukayama; Kunihiko Mabuchi; Takayuki Hoshino


生体医工学 | 2014

Recording and regulation of neuroral networks in vitro using microfabrication techniques

Yuzo Takayama; Takafumi Suzuki; Kunihiko Mabuchi; Yasuhiko Jimbo


The Proceedings of the Symposium on Micro-Nano Science and Technology | 2014

22am2-F5 Two-dimensional Control of Nanofluidics by Dynamic Electron Beam Lithography

Hiroki Miyazako; Kunihiko Mabuchi; Takayuki Hoshino

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Takafumi Suzuki

National Institute of Information and Communications Technology

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Yuzo Takayama

National Institute of Advanced Industrial Science and Technology

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