Kurenai Tanji

A MORPHOLOGICAL STUDY ON THE EFFECTS OF COLLAGEN GEL MATRIX ON REGENERATION OF SEVERED RAT SCIATIC NERVE IN SILICONE TUBES

The present study is a chronological morphological examination on the effects of collagen gel matrix on regeneration of severed sciatic nerves. The nerves (5 mm length) were resected, and both the distal and proximal stumps were inserted into a silicone tube with 5 mm gap in between. In the test side, the gap in the tube was then injected with liquid collagen which gells in the tissue when reconstructed with a certain buffer solution. The gap space in the tube of the control side was left empty. In a chronological examination of the tissue in the tube, considerably more rapid growth of sprouting axons toward the distal stump in the test side was revealed in comparison with the control side. The cells, including both fibroblasts and larger Schwann cells, were less in number. More orderly directions were observed in the collagen matrix than in the control tube. The result indicates that regeneration of the peripheral nerves in the silicone tube can be improved, by using appropriate exogenous fine materials, collagen matrix.

A case of malignant transformation in thoracic vertebral hemangioma following repetitive irradiation and extraction

We report a rare case of thoracic vertebral hemangioma which developed into angiosarcoma during the course of repetitive operations and irradiation. A 44 year old female was operated on for hemangioma of the first thoracic vertebra. The diagnosis of hemangioma was confirmed histo‐pathologically with the specimen from the first operation. The tumor developed multiple lesions later in the clinical course after the first operation, these lesions were removed in four consecutive operations and each histologlcai diagnosis was that of hemangioma. Throughout the period of these operations, the patient was treated wtih steroid, and with radiotherapy simultaneously. The patient underwent the fifth operation for the recurrence of the tumor on 26 March 1990, and the histopathological diagnosis was not hemangioma but hemangiosarcoma which was considered a malignant transformation. The tumor cells immunohistochemically revealed positive staining with UEA‐I, Factor‐VIII, as the tumor immunohistochemically showed a vascular endothe‐lioid nature.

A case in which cytodiagnosis was useful for evaluation of aspergillus.

脾カンジダ症を伴った気管支肺アスペルギルス症の1剖検例を報告し, それを用いて, 内臓真菌症の中でも原因菌属としてカンジダに次いで最も多いアスペルギルスの同定を, 菌糸のみの形態的特徴から試みた.症例は43歳, 女性. 急性前骨髄球性白血病の再燃例で右肺中・下葉および左上葉にアスペルギルスによる肺炎をきたし, 右中・下葉の一部は横隔膜に癒着し, 右出血性胸膜炎を呈していた.左上葉では空洞を形成していた. 脾には結節状のカンジダ感染が認められた. 剖検時に右肺・横隔膜癒着部および左上葉空洞内の壊死物の塗抹標本を作製したところ, アスペルギルスの菌糸の特徴すなわち, Y字状に2分岐しながら一方向へ向かって増殖するようすがきわめて明瞭に見い出され, 組織標本で観察できた菌糸形態よりも真菌の同定に役立つと考えられた.