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Dive into the research topics where Kurt E. Merkel is active.

Publication


Featured researches published by Kurt E. Merkel.


Journal of Chromatography A | 1985

Liquid chromatographic separation of aminoglycosides with pulsed amperometric detection

John A. Polta; Dennic C. Johnson; Kurt E. Merkel

Abstract The absence of strong chromophoric groups in aminoglycoside antibiotics virtually eliminates the possibility of their photometric detection in analytical liquid chromatography Pulsed amperometric detection is described for the sensitivity detection of several nebramycin factors following separation on a neutral polystyrene column. The alkaline eluent (0.25 M sodium hydroxide) is appropriate as the electrolyte for the electrochemical detection, and the need for post-column addition of reagents is avoided. The use of a coupled fore-column is illustrated for on-line preconcentration when concentrations are below ca. 1 ppm in 50-μl samples (i.e., ca. 50 ng).


The Journal of Antibiotics | 1984

Actaplanin, new glycopeptide antibiotics produced by Actinoplanes missouriensis. The isolation and preliminary chemical characterization of actaplanin.

Manuel Debono; Kurt E. Merkel; R. Michael Molloy; Mitchell Barnhart; Eugene Presti; Ann H. Hunt; Robert L. Hamill


Archive | 1981

Antibiotic a-4696 factors b1,b2,b3,c1a,c3 and e1

Manuel Debono; Kurt E. Merkel; Robert Edgar Weeks; Herald James Cole


Journal of Organic Chemistry | 1978

Structures of some of the minor aminoglycoside factors of the nebramycin fermentation

K. F. Koch; Kurt E. Merkel; S. C. O'Connor; John L. Occolowitz; Jonathan W. Paschal; Douglas E. Dorman


Journal of the American Chemical Society | 1988

M43 antibiotics: methylated vancomycins and unrearranged CDP-1 analogs.

Ramakrishnan Nagarajan; Kurt E. Merkel; Karl H. Michel; Harvey M. Higgins; Marvin M. Hoehn; Ann H. Hunt; Noel D. Jones; John L. Occolowitz; Amelia Apolinaria Schabel; John K. Swartzendruber


Journal of Organic Chemistry | 1984

Structure of the pseudoaglycon of actaplanin

Ann H. Hunt; Manuel Debono; Kurt E. Merkel; Mitchell Barnhart


Archive | 1984

Antibiotic M43D, pharmaceutical compositions and method of use

Kurt E. Merkel


Journal of Organic Chemistry | 1984

Structures of the actaplanins

Ann H. Hunt; Thomas K. Elzey; Kurt E. Merkel; Manuel Debono


Archive | 1985

Improvements in and relating to antibiotics M43A, M43B, M43C and M43D

Harvey M. Higgins; Mack Harold Mccormick; Kurt E. Merkel; Karl H. Michel


Archive | 1981

Biologically pure culture of Actinoplanes missouriensis

Manuel Debono; Kurt E. Merkel; Robert Edgar Weeks; Herald James Cole

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