Kwangyeol Lee

Nanomaterials for Theranostics: Recent Advances and Future Challenges

Challenges Eun-Kyung Lim,†,‡,§ Taekhoon Kim, Soonmyung Paik, Seungjoo Haam, Yong-Min Huh,*,† and Kwangyeol Lee* Department of Chemistry, Korea University, Seoul 136-701, Korea †Department of Radiology, Yonsei University, Seoul 120-752, Korea Severance Biomedical Research Institute, Yonsei University College of Medicine, Seoul 120-749, Korea Division of Pathology, NSABP Foundation, Pittsburgh, Pennsylvania 15212, United States Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, Korea ‡BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea Electronic Materials Laboratory, Samsung Advanced Institute of Technology, Mt. 14-1, Nongseo-Ri, Giheung-Eup, Yongin-Si, Gyeonggi-Do 449-712, Korea

Convertible Organic Nanoparticles for Near-Infrared Photothermal Ablation of Cancer Cells†

Well-designed photothermal nanomaterials have attractedthe interest of many scientists pursuing a better means toaccurately diagnose cancer and assess the efficacy of treat-ment, because these materials enable therapies in which thetumor region is pin-pointed with a laser-guided light sourcewithout surgical intervention.

Hollow Silica Nanocontainers as Drug Delivery Vehicles

Novel hollow silica nanoparticles (HSNPs) for drug delivery vehicles were synthesized using silica-coated magnetic assemblies, which are composed of a number of Fe(3)O(4) nanocrystals, as templates. The core cavity was obtained by removal of Fe(3)O(4) phase with hydrochloric acid and subsequent calcination at a high temperature. HSNPs were modified by amine in order to introduce positive surface charge and further PEGylated for increased solubility in aqueous medium. Doxorubicin as a model drug was loaded into the HSNPs, and notable sustained drug release from HSNPs was demonstrated.

Room-temperature semiconductor gas sensor based on nonstoichiometric tungsten oxide nanorod film

Porous tungsten oxide films were deposited onto a sensor substrate with a Si bulk-micromachined hotplate, by drop-coating isopropyl alcohol solution of highly crystalline tungsten oxide (WO2.72) nanorods with average 75nm length and 4nm diameter. The temperature-dependent gas sensing characteristics of the films have been investigated over the mild temperature range from 20to250°C. While the sensing responses for ammonia vapor showed increase in electrical conductivity at temperatures above 150°C as expected for n-type metal oxide sensors, they exhibited the opposite behavior of unusual conductivity decrease below 100°C. Superb sensing ability of the sensors at room temperature in conjunction with their anomalous conductivity behavior might be attributed to unique nanostructural features of very thin, nonstoichiometric WO2.72.

Serum adiponectin concentrations predict the developments of type 2 diabetes and the metabolic syndrome in elderly Koreans

objective  To determine whether low serum adiponectin concentrations are able to predict the future developments of type 2 diabetes and the metabolic syndrome using the National Cholesterol Education Programme (NCEP) criteria. We also investigated the stability of adiponectin levels and the relationships between baseline adiponectin levels and changes in the parameters related to the metabolic syndrome over a period of 3 years.

pH-triggered drug-releasing magnetic nanoparticles for cancer therapy guided by molecular imaging by MRI.

E.-K. Lim , Prof. S. Haam Department of Chemical and Biomolecular EngineeringYonsei UniversitySeoul 120-749, Republic of Korea E-mail: haam@yonsei.ac.kr Prof. .-M. Y Huh , Prof. J. ang , Y Prof. J.-S. Suh Department of RadiologyYonsei UniversitySeoul 120-752, Republic of KoreaE-mail: jss@yuhs.ac Prof. .-M. Y Huh , Prof. J. ang , Y Prof. J.-S. Suh , Prof. S. Haam YUHS-KRIBB Medical Convergence Research InstituteSeoul 120-752, Republic of Korea Prof. .-M. Y Huh , Prof. J.-S. Suh Severance Biomedical Science Institute(SBSI)Seoul 120-752, Republic of Korea Prof. K. Lee Department of ChemistryKorea UniversitySeoul 136-701, Republic of Korea

Smart Drug‐Loaded Polymer Gold Nanoshells for Systemic and Localized Therapy of Human Epithelial Cancer

Near-infrared-light-sensitive multifunctional smart drug-loaded polymer gold nanoshells are fabricated as advanced prototypes, composed of chemotherapeutic agents (therapeutic antibody and anticancer drug-loaded polymeric nanoparticles) for systemic chemotherapy of human epithelial cancer and a polymer-based gold nanoshell for localized photothermal treatment by NIR light.

Catalytic nanoparticles being facet-controlled

The catalytic properties of nanoparticles are determined by the nature of nanoparticle surface. Thus facet-controlled synthesis of catalytic nanoparticles is of paramount importance for both reactive and selective catalysis, and recently various successful synthetic methodologies have been developed to give a number of facet-controlled nanoparticles. In this review, we highlight these recent developments in facet-controlled nanoparticle synthesis along with novel strategies to enhance nanoparticle stability and reactivity.

Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection

Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe(2)O(4) magnetic nanocrystals encapsulated in pyrene-labeled PCL-b-PMAA as a surfactant prepared by a nano-emulsion method. FMNHs demonstrated excellent colloidal stability and biocompatibility for biomedical application. Antibody conjugated fluorescent magnetic nanohybrids (CET-FMNHs) served as effective agents for both magnetic resonance (MR) and fluorescence optical imaging of cancer cell lines.

Highly Photosensitive J‐Aggregated Single‐Crystalline Organic Transistors

Charge-transport phenomena and photoinduced charge generation of organic semiconductors have potential applications in many electronic and optoelectronic devices. Organic fi eld-effect transistors (OFETs) are the most promising electronic devices fabricated using either well-defi ned single crystals (SCs) or thin fi lms as the charge-transporting layers. [ 1–3 ] In particular, soluble organic semiconductors are attracting attention for use in the fabrication of low-cost, large-scale, and practical devices. [ 4 , 5 ]