Seungjoo Haam
Yonsei University
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Publication
Featured researches published by Seungjoo Haam.
Chemical Reviews | 2015
Eun Kyung Lim; Taekhoon Kim; Soonmyung Paik; Seungjoo Haam; Yong Min Huh; Kwangyeol Lee
Challenges Eun-Kyung Lim,†,‡,§ Taekhoon Kim, Soonmyung Paik, Seungjoo Haam, Yong-Min Huh,*,† and Kwangyeol Lee* Department of Chemistry, Korea University, Seoul 136-701, Korea †Department of Radiology, Yonsei University, Seoul 120-752, Korea Severance Biomedical Research Institute, Yonsei University College of Medicine, Seoul 120-749, Korea Division of Pathology, NSABP Foundation, Pittsburgh, Pennsylvania 15212, United States Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, Korea ‡BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea Electronic Materials Laboratory, Samsung Advanced Institute of Technology, Mt. 14-1, Nongseo-Ri, Giheung-Eup, Yongin-Si, Gyeonggi-Do 449-712, Korea
ACS Nano | 2009
Huiyul Park; Jaemoon Yang; Jaemin Lee; Seungjoo Haam; In-Hong Choi; Kyung-Hwa Yoo
To facilitate combined doxorubicin and photothermal treatments, we developed doxorubicin-loaded poly(lactic-co-glycolic acid)-gold half-shell nanoparticles (DOX-loaded PLGA-Au H-S NPs) by depositing Au films on DOX-loaded PLGA NPs. As the PLGA NPs biodegraded, DOX was released, and heat was locally generated upon near-infrared (NIR) irradiation due to NIR resonance of DOX-loaded PLGA H-S NPs. Compared with chemotherapy or photothermal treatment alone, the combined treatment demonstrated a synergistic effect, resulting in higher therapeutic efficacy and shorter treatment times. Since our NPs selectively deliver both heat and drug to tumorigenic regions, they may improve the therapeutic effectiveness with minimal side effects.
Angewandte Chemie | 2011
Jaemoon Yang; Jihye Choi; Doyeon Bang; Eun Jung Kim; Eun Kyung Lim; Huiyul Park; Jin Suck Suh; Kwangyeol Lee; Kyung Hwa Yoo; Eun-Kyung Kim; Yong Min Huh; Seungjoo Haam
Well-designed photothermal nanomaterials have attractedthe interest of many scientists pursuing a better means toaccurately diagnose cancer and assess the efficacy of treat-ment, because these materials enable therapies in which thetumor region is pin-pointed with a laser-guided light sourcewithout surgical intervention.
Langmuir | 2008
Jaemoon Yang; Jae Won Lee; Jinyoung Kang; Kwangyeol Lee; Jin Suck Suh; Ho Geun Yoon; Yong Mip Huh; Seungjoo Haam
Novel hollow silica nanoparticles (HSNPs) for drug delivery vehicles were synthesized using silica-coated magnetic assemblies, which are composed of a number of Fe(3)O(4) nanocrystals, as templates. The core cavity was obtained by removal of Fe(3)O(4) phase with hydrochloric acid and subsequent calcination at a high temperature. HSNPs were modified by amine in order to introduce positive surface charge and further PEGylated for increased solubility in aqueous medium. Doxorubicin as a model drug was loaded into the HSNPs, and notable sustained drug release from HSNPs was demonstrated.
Advanced Materials | 2011
Eun Kyung Lim; Yong Min Huh; Jaemoon Yang; Kwangyeol Lee; Jin Suck Suh; Seungjoo Haam
E.-K. Lim , Prof. S. Haam Department of Chemical and Biomolecular EngineeringYonsei UniversitySeoul 120-749, Republic of Korea E-mail: [email protected] Prof. .-M. Y Huh , Prof. J. ang , Y Prof. J.-S. Suh Department of RadiologyYonsei UniversitySeoul 120-752, Republic of KoreaE-mail: [email protected] Prof. .-M. Y Huh , Prof. J. ang , Y Prof. J.-S. Suh , Prof. S. Haam YUHS-KRIBB Medical Convergence Research InstituteSeoul 120-752, Republic of Korea Prof. .-M. Y Huh , Prof. J.-S. Suh Severance Biomedical Science Institute(SBSI)Seoul 120-752, Republic of Korea Prof. K. Lee Department of ChemistryKorea UniversitySeoul 136-701, Republic of Korea
Biomaterials | 2010
Eun Jung Kim; Yukyung Jung; Hyangtae Choi; Jaemoon Yang; Jin-Suck Suh; Yong-Min Huh; Kunhong Kim; Seungjoo Haam
We investigated the synergism between shRNAs against Bcl-xL and doxorubicin (DOX) using aptamer-conjugated polyplexes (APs) in combination cancer therapy. Synergistic and selective cancer cell death was achieved by AP-mediated co-delivery of very small amounts of DOX and Bcl-xL-specific shRNA, which simultaneously activated an intrinsic apoptotic pathway. A branched polyethyleneimine (PEI) was grafted to polyethylene glycol (PEI-PEG) to serve as a vehicle for shRNA delivery, and its surface was further conjugated with an anti-PSMA aptamer (APT) for the selective delivery of APs to prostate cancer cells that express prostate-specific membrane antigens (PSMA) on their cell surface. The APs were finally obtained after intercalation of DOX to form shRNA/PEI-PEG-APT/DOX conjugates. Cell viability assays and FACS analysis of GFP expression against PC3 (PSMA deficient) and LNCaP (PSMA overexpressed) cells demonstrated that the synthesized APs inhibited the growth of PSMA-abundant prostate cancer cells with strong cell selectivity. Consequently, IC(50) values of APs loaded with both DOX and shRNA were approximately 17-fold less than those for the simple mixture of shRNA plus drug (shRNA/Lipofectamine + DOX). These results suggest that AP-mediated co-delivery of an anti-cancer drug and shRNA against Bcl-xL may widen the therapeutic window and allow for the selective destruction of cancer cells.
Journal of Materials Chemistry | 2007
Jaemoon Yang; Choong-Hwan Lee; Joseph Park; Sungbaek Seo; Eun-Kyung Lim; Yong Jin Song; Jin-Suck Suh; Ho-Geun Yoon; Yong-Min Huh; Seungjoo Haam
DOX–magnetic PLGA nanoparticles conjugated with well-tailored antibodies were synthesized for the detection and therapy of breast cancer. Magnetic nanocrystals embedded in polymeric nanoparticles did not inhibit the nanoparticle formulation or drug release kinetics. The multimodal nanoparticles demonstrated remarkable cancer cell affinity and ultrasensitivity via magnetic resonance imaging. Furthermore, the loaded anticancer drugs were released and sustained for three weeks.
Advanced Materials | 2009
Jaemoon Yang; Jae Won Lee; Jinyoung Kang; Seung Jae Oh; Hyun Ju Ko; Joo Hiuk Son; Kwangyeol Lee; Jin Suck Suh; Yong Min Huh; Seungjoo Haam
Near-infrared-light-sensitive multifunctional smart drug-loaded polymer gold nanoshells are fabricated as advanced prototypes, composed of chemotherapeutic agents (therapeutic antibody and anticancer drug-loaded polymeric nanoparticles) for systemic chemotherapy of human epithelial cancer and a polymer-based gold nanoshell for localized photothermal treatment by NIR light.
Optics Express | 2009
Seung Jae Oh; Jinyoung Kang; Inhee Maeng; Jin-Suck Suh; Yong-Min Huh; Seungjoo Haam; Joo Hiuk Son
This paper demonstrates the principle of the nanoparticle-contrast-agent-enabled terahertz imaging (CATHI) technique, which yields a dramatic sensitivity of the differential signal from cancer cells with nanoparticles. The terahertz (THz) reflection signal increased beam by 20% in the cancer cells with nanoparticles of gold nano-rods (GNRs) upon their irradiation with a infrared (IR) laser, due to the temperature rise of water in cancer cells by surface plasma ploritons. In the differential mode, the THz signal from the cancer cells with GNRs was 30 times higher than that from the cancer cells without GNRs. As the high sensitivity is achieved by the surface plasmon resonance through IR laser irradiation, the resolution of the CATHI technique can be as good as a few microns and THz endoscopy becomes more feasible.
Biomaterials | 2008
Jaemoon Yang; Eun Kyung Lim; Hong Jae Lee; Joseph Park; Sang Cheon Lee; Kwangyeol Lee; Ho Geun Yoon; Jin Suck Suh; Yong Min Huh; Seungjoo Haam
Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe(2)O(4) magnetic nanocrystals encapsulated in pyrene-labeled PCL-b-PMAA as a surfactant prepared by a nano-emulsion method. FMNHs demonstrated excellent colloidal stability and biocompatibility for biomedical application. Antibody conjugated fluorescent magnetic nanohybrids (CET-FMNHs) served as effective agents for both magnetic resonance (MR) and fluorescence optical imaging of cancer cell lines.