Kyoichi Adachi

Comparison of endoscopic findings with symptom assessment systems (FSSG and QUEST) for gastroesophageal reflux disease in Japanese centres

Background and Aim:u2002 We compared endoscopic findings of the frequency scale for the symptoms of gastroesophageal reflux disease (FSSG), a written questionnaire developed in Japan, to that for the questionnaire for the diagnosis of reflux esophagitis (QUEST) for the diagnosis of reflux esophagitis.

Generation of dyspeptic symptoms by direct acid infusion into the stomach of healthy Japanese subjects

Objective The relationship between acid and dyspeptic symptoms has not been fully understood.

Efficacy of prokinetic agents in improving bowel preparation for colonoscopy.

Background and Aim: Colonoscopy plays an important role in the diagnosis and treatment of gastrointestinal illness in both Western countries and Japan. However, preparative bowel cleansing for colonoscopy is frequently troublesome for elderly and/or constipated patients, since they must drink larger volumes of lavage solution for adequate cleansing. We investigated the use of prokinetic agents for improving the efficacy and tolerability of bowel cleansing prior to colonoscopy. Methods: 613 patients were divided into two groups according to oral lavage solution used (polyethylene glycol or magnesium citrate), and were further randomized to receive either vehicle (100 ml water) alone, vehicle with 5 mg mosapride citrate, or vehicle with 50 mg itopride hydrochloride 30 min before administration of lavage solution. Experimental parameters included bowel cleansing quality, times to first defecation and completion of bowel cleansing, and incidence of uncomfortable abdominal symptoms during colonoscopy preparation. Results: Administration of mosapride citrate or itopride hydrochloride prior to oral lavage solution did not significantly improve bowel cleansing quality. However, statistically significantly fewer uncomfortable abdominal symptoms were found in patients who received mosapride citrate or itopride hydrochloride versus vehicle alone. Conclusion: Prokinetic agents effectively decreased the incidence of uncomfortable abdominal symptoms experienced during colonoscopy preparation.

Predictors for squamous re-epithelialization of Barrett’s esophagus after endoscopic biopsy

Background and Aim:u2002 Acid suppressive therapy has been reported to regress Barrett’s esophagus. However, it is still controversial as to whether all Barrett’s esophagus patients respond to this therapy. The factors that might facilitate newly developed squamous re‐epithelialization after biopsy excision of Barrett’s mucosa were evaluated to identity individuals who may favorably respond to the regression therapy.

Prophylactic administration of antibiotics unnecessary following ultrasound-guided biopsy and ablation therapy for liver tumors: Open-labeled randomized prospective study.

Aim:u2002 To determine the prophylactic effect of antibiotics administration in the prevention of infection following an ultrasound‐guided percutaneous liver biopsy or treatment of liver tumors, we performed an open‐labeled randomized prospective study of patients who received prophylactic antibiotics after undergoing those procedures.

Study of arteriosclerosis in patients with hiatal hernia and reflux esophagitis

Background and Aim:u2002 It has been reported that the prevalence of hiatal hernia (HH) and reflux esophagitis (RE) increases with age, as does the degree of arteriosclerosis. However, it has not been investigated whether or not arteriosclerosis is correlated with the presence of HH and RE. Therefore, we prospectively investigated the degree of arteriosclerosis in patients with HH and RE compared with subjects without HH and RE.