Kyoji Okada

Foot Pressure Pattern and its Correlation With Knee Range of Motion Limitations for Individuals With Medial Knee Osteoarthritis

OBJECTIVEnTo determine the foot pressure pattern of individuals with medial knee osteoarthritis (OA) and to analyze its relation with knee flexion/extension range of motion.nnnDESIGNnDescriptive.nnnSETTINGnRehabilitation center.nnnPARTICIPANTSnIndividuals with unilateral, painful medial knee OA (n=50; mean age, 75y; OA group) were enrolled as subjects, and young, healthy persons (n=50; mean age, 28y; young group) and elderly persons (n=44; mean age, 74y; elderly group) without any pain, deformity, or apparent OA changes in either knee were enrolled as controls.nnnINTERVENTIONnWalking 10m at a comfortable speed.nnnMAIN OUTCOME MEASURESnPartial foot pressures as percentages of body weight (%PFP), anteroposterior length of the center of pressure (COP) path as a percentage of foot length (%Long), transverse width of the COP path as a percentage of foot width (%Trans), knee flexion/extension range of motion (in the OA group).nnnRESULTSnThe %PFP values for the heel and hallux, %Long, and %Trans were all significantly lower in the OA group than in controls (P<.001, all). Within the OA group, a limited range of knee extension was significantly associated with a short %Long (P<.001) but not with %Trans.nnnCONCLUSIONSnIndividuals with medial knee OA exhibited low pressure on the heel and hallux and short %Long of the COP path, and limitation of knee extension was associated with shortness of %Long. The shortness of %Long in the OA group likely resulted from insufficient knee extension during the heel-contact phase associated with low pressure on the heel. %Long is a useful parameter in gait analysis by using a foot pressure measurement system.

A clinicopathological study of giant cell tumor of small bones

Abstract Background and purpose. Giant cell tumor (GCT) of the small bones (small-bone GCT) is usually rare and considered somewhat different from conventional GCT. The purpose of this study was to investigate and report the clinicopathological features of 11 cases with small-bone GCT. Materials and methods. Patient information was obtained with the help of questionnaires. X-rays and paraffin blocks obtained from several institutions were clinically, radiographically, and histologically evaluated. Results. Small-bone GCT was observed in younger patients compared to conventional GCT; 5 of the 11 (45%) patients were below 20 years of age, whereas the corresponding figure for all GCT patients is 16% in Japan. Excessive cortical bone expansion is a special feature. There were two cases of recurrence and one case of lung metastasis; the primary lesion was in the hand for all three cases. In contrast, no primary lesion of the foot recurred or metastasized. Varying degrees of positive p63 immunostaining were observed in all examined cases (n = 9) of small-bone GCT but were negative in case of giant cell reparative granuloma (GCRG) and solid variant of aneurysmal bone cyst (ABC). One case that demonstrated high-intensity positive staining had two episodes of recurrence. Conclusion. Small-bone GCT tends to develop in younger patients than does conventional GCT. Primary GCTs of the hand may be biologically more aggressive than those of the feet. The p63 immunostaining may be useful not only for differential diagnosis but also for prognostication of small-bone GCT.

Primary (De Novo) Dedifferentiated Liposarcoma in the Extremities: A Multi-Institution Tohoku Musculoskeletal Tumor Society Study of 18 Cases in Northern Japan

OBJECTIVEnDedifferentiated liposarcomas usually occur in the retroperitoneal space and relatively rarely in the extremities.nnnMETHODSnWe identified 18 patients with primary dedifferentiated liposarcoma in the extremities from the files of Tohoku Musculoskeletal Tumor Society and analyzed demographics, histologic findings, treatments and prognostic factors. The average follow-up period was 58 months.nnnRESULTSnThe subjects were 12 men and 6 women with a mean age of 65 years. All tumors were in the thigh. Nine patients noticed a rapid enlargement of the long-standing tumor. Histologic subtypes of the dedifferentiated area were undifferentiated pleomorphic sarcoma (n = 12), osteosarcoma (n = 2), rhabdomyosarcoma (n = 2), leiomyosarcoma (n = 1) and malignant peripheral nerve sheath tumor (n = 1). In the patient with rhabdomyosarcoma-like dedifferentiated area, extensive necrosis was observed after the preoperative chemotherapy. One patient who underwent marginal excision developed a local recurrence, but inadequate surgical margin was not associated with a risk of local recurrence. Three patients had lung metastasis at initial presentation, and four other patients developed lung metastases during the follow-up period. The overall survival rate was 61.1% at 5 years. On univariate analyses, large size of the dedifferentiated area (>8 cm), high MIB-1-labeling index (>30%) for the dedifferentiated area and lung metastasis at initial presentation were significantly associated with poor prognosis.nnnCONCLUSIONSnPrimary dedifferentiated liposarcoma in the extremities predominantly occurred in the thigh and a rapid enlargement of long-standing tumors was a characteristic symptom. Although the local behavior of these tumors was less aggressive than that of retroperitoneal dedifferentiated liposarcomas, they had a relatively high metastatic potential.

p63 as a prognostic marker for giant cell tumor of bone

Abstract Background and purpose. Giant cell tumor of bone (GCT) is sometimes difficult to distinguish from other giant-cell-rich tumors such as chondroblastoma (CHB) and aneurysmal bone cyst (ABC). The usefulness of p63 as a diagnostic marker for GCT is controversial. While there have been no reports about p63 as a prognostic marker for local recurrence, various p63-positive rates in GCT have been reported. The purpose of this study was to investigate retrospectively whether p63 is useful as a diagnostic marker and/or a prognostic marker for local recurrence of GCT. Methods. This study included 36 patients diagnosed with either GCT (n = 16), CHB (n = 9), ABC (n = 7), or non-ossifying fibroma (NOF) (n = 4). p63 immunostaining was performed for all specimens. The mean p63-positive rate was compared with the four diseases and between the recurrent and non-recurrent cases of GCT. Results. Although the mean p63-positive rate for GCT (36.3%) was statistically higher than that of all other diseases examined (CHB: 15.2%; ABC: 5.8%; NOF: 3.4%), p63 was not specific for GCT. The mean p63-positive rate for recurrent GCT cases (73.6%) was statistically higher than that for non-recurrent cases (29.1%). Conclusion. In the diagnosis of GCT, p63 is a useful but not a conclusive marker. However, p63 did appear to indicate the biological aggressiveness of GCT. Therefore, p63 may help surgeons to estimate the risk of recurrence after surgery and help them to choose the best treatment for each GCT case.

Elasticity of the pronator teres muscle in youth baseball players with elbow injuries: evaluation using ultrasound strain elastography

BACKGROUNDnAlthough the pronator teres muscle, a major dynamic stabilizer of elbow valgus stress during throwing, frequently presents stiffness, its relationship with elbow injuries in youth baseball players is unknown. This study investigated the relationship between the elasticity of the pronator teres muscle and elbow injuries in youth baseball players.nnnMETHODSnThe strain ratio (SR) of 15 individuals with osteochondritis dissecans of the humeral capitellum (OCD group), 67 individuals with medial epicondylar fragmentation (medial injury group), and 115 healthy individuals (control group) was measured as the index of the elasticity of the pronator teres muscle using ultrasound strain elastography. In addition, the forearm and glenohumeral joint rotation range of motion was measured.nnnRESULTSnThe SR of the throwing arm was significantly higher in the OCD and medial injury groups than in the control group (both Pu2009<.001). In the OCD group, the SR was significantly higher in the throwing arm than in the nonthrowing arm (Pu2009<.001), whereas in the medial injury group, there was no significant difference between both arms. The glenohumeral joint external rotation range of motion of the throwing arm was moderately negatively correlated with the SR (ru2009= -0.478, Pu2009<.001).nnnCONCLUSIONSnStiffness of the pronator teres muscle was exhibited only in the throwing arm of individuals with OCD and in both arms in individuals with medial elbow injury. These findings may contribute to an accurate evaluation and prevention of elbow injuries in youth baseball players.

Foot pressure pattern, hindfoot deformities, and their associations with foot pain in individuals with advanced medial knee osteoarthritis

This survey clarified foot pressure patterns and hindfoot deformities in individuals with advanced knee osteoarthritis (OA) and analyzed their associations with foot pain. Sixty-four individuals with unilateral knee OA who underwent total knee arthroplasty (TKA) were divided into the following groups: no foot pain (n=26; men:women, 4:22; mean age, 73.7 years), foot pain resolved after TKA (12; 2:10; 75.8), and foot pain remaining after TKA (26; 4:22; 74.7). Elderly individuals without pain or deformity in either knee (54; 10:44; 74.3) were controls. Navicular height ratio of the medial longitudinal arch, leg-heel angle, and partial foot pressure as the percentage of body weight (%PFP) were calculated.%PFPs of the medial and lateral heel regions before TKA were significantly lower for the no foot pain group than for controls. One year after TKA, %PFP improved significantly. In the foot pain resolved group, before TKA, the leg-heel angle was significantly higher, and%PFPs of the medial and lateral heel regions and navicular height ratio before TKA were significantly lower than those of controls. One year after TKA, all parameters improved significantly. In the foot pain remaining group, similar abnormalities were observed before TKA; however, significant improvement was only observed for%PFP of the medial heel region 1year after TKA. More than half of the patients with advanced knee OA had foot pain. This improved in approximately one-third, 1year after TKA. Hindfoot deformities are probably associated with foot pain in individuals with advanced knee OA.

The association between the maximum step length test and the walking efficiency in children with cerebral palsy

[Purpose] To improve walking efficiency could be useful for reducing fatigue and extending possible period of walking in children with cerebral palsy (CP). For this purpose, current study compared conventional parameters of gross motor performance, step length, and cadence in the evaluation of walking efficiency in children with CP. [Subjects and Methods] Thirty-one children with CP (21 boys, 10 girls; mean age, 12.3 ± 2.7u2005years) participated. Parameters of gross motor performance, including the maximum step length (MSL), maximum side step length, step number, lateral step up number, and single leg standing time, were measured in both dominant and non-dominant sides. Spatio-temporal parameters of walking, including speed, step length, and cadence, were calculated. Total heart beat index (THBI), a parameter of walking efficiency, was also calculated from heartbeats and walking distance in 10 minutes of walking. To analyze the relationships between these parameters and the THBI, the coefficients of determination were calculated using stepwise analysis. [Results] The MSL of the dominant side best accounted for the THBI (R2=0.759). [Conclusion] The MSL of the dominant side was the best explanatory parameter for walking efficiency in children with CP.

Ultrasonographic Morphologic Changes of the Central Aponeurosis of the Rectus Femoris Muscle in Individuals With Knee Osteoarthritis.

Abstract The aim of this study was to clarify the morphologic characteristics of central aponeurosis (CA) of the rectus femoris (RF) muscle in individuals with medial knee osteoarthritis (OA). Forty legs in 26 individuals with medial knee OA (OA group), 41 legs in 21 elderly individuals (elderly group), and 40 legs in 20 young individuals (young group) were investigated. We measured the following 4 parameters: (1) ratio of CA length, expressed as the percentage of RF length; (2) CA morphologic type (curved, straight, S-shaped, or irregular); (3) CA direction, defined as the direction of the line from the anterior to posterior ends of the CA (lateral or medial); and (4) intercondylar distance (ICD). Ratio of CA length in the OA group was significantly smaller than that in the other 2 groups. The curved CA type was significantly more frequent in the young group than in the other 2 groups. The irregular type was observed in only 7 legs in the OA group. In the young group, CA direction was classified as medial in all cases. Laterally directed CA was observed only in the OA and elderly groups. Within the OA group, ICD in laterally directed CA was significantly larger than that in medially directed CA. Central aponeurosis observed in the RF muscle in individuals with medial knee OA is shorter and sometimes shows an irregular shape. Laterally directed CA is associated with increased ICD in knee OA. Attention should be given to the tendon-aponeurosis complex in individuals with medial knee OA.

Foot Pressure Pattern During Walking in Individuals with Anterior Cruciate Ligament Injury.

BACKGROUNDnWe evaluated foot pressure distribution during walking in individuals with anterior cruciate ligament (ACL) injury.nnnMETHODSnOur study included 24 ACL-deficient patients and 22 healthy young adults as controls. The former group was divided into the dominant-side ACL-deficient group (n = 17) and the nondominant-side ACL-deficient group (n = 7). The following parameters were calculated from the path of the center of pressure (COP) on a foot pressure distribution system: percentage of COP (%COP; the ratio of anteroposterior COP path length to foot length), percentage of COP locus area (%CLA; the ratio of the area encompassed by the COP path and a line between the start and end points of the COP path to foot area), and the value of maximum amplitude of COP (MACOP; the maximum perpendicular length from the COP path to a line between the start and end points of the COP).nnnRESULTSnIn the nondominant-side ACL-deficient group, %COP (P = .026), %CLA (P = .001), and MACOP (P =.012) on the injured side were significantly lower than those in the nondominant leg side of the control group. No significant differences were found between the dominant-side ACL-deficient group and the control group.nnnCONCLUSIONSnShortening of the COP trace in the nondominant-side ACL-deficient group may be associated with knee flexion during walking at heel contact. Because the parameters used herein can be obtained easily, repetitively, and quantitatively, they should be used in evaluating the gait of patients with ACL-deficient knees.