Kyung-Tea Lee

FAK Pathway Regulates PGE2 Production in Compressed Periodontal Ligament Cells

This study examined the role of focal adhesion kinase (FAK) as a mechanoreceptor in human periodontal ligament (hPDL) cells. hPDL cells were obtained from premolars extracted for orthodontic purposes. Mechanical stress was applied in a compressive manner (2 g/cm2) for various time durations (0.5, 2, 6, 24, 48 hrs) with or without a knockdown treatment for FAK. Compressive stimulation increased the level of phosphorylated FAK and prostaglandin E2 production. The FAK-knockdown cells showed significantly lower prostaglandin E2 levels than the control cells. Furthermore, compressive stress up-regulated cyclo-oxygenase-2 mRNA, whereas there were no changes observed in the FAK-knockdown cells. These results suggest that FAK regulates the production of prostaglandin E2 via the transcriptional regulation of COX-2 mRNA in compressive stimulated PDL cells. The FAK-integrin complex plays a role in mechanoreception and mechanotransduction in hPDL cells.

Comparison of SOHO/UVCS and MLSO MK4 Coronameter Densities

We have compared the density distributions of solar corona obtained by SOHO Ultraviolet Coronagraph Spectrometer (UVCS) and Mauna Loa Solar Observatory (MLSO) MK4 coronameter. This is the first attempt to compare the coronal densities estimated by the two instruments. In the spectral data of UVCS, we have selected two emission lines (O vi 1032 A and 1037.6 A), which have both radiative and collisional components. The coronal number density is determined from the ratio of these two components. The MK4 coronameter has a field of view ranging from 1.08 to 2.85 solar radii. The coronal density can be determined by inverting MLSO MK4 polarization maps. We find that the mean electron number density in a helmet streamer observed by MK4 on 2003 April 28 is fairly consistent with that observed by UVCS. For a coronal hole and an active region observed on 1999 October 19 and 24, the MK4 coronal densities are close to those from the UVCS within a factor of two; the former values are twice the latter at 1.7 solar radii and closer to the latter at higher altitudes. Our results demonstrate that MK4 polarization data can provide us with a coronal density distribution in a large field of view with a time cadence of about three minutes. We suggest that the MK4 data can be used to derive 2-D density distributions of coronal structures and further to estimate the heights of CME-associated type II shocks.

ESTIMATE OF CORONAL MAGNETIC FIELD STRENGTH USING PLASMOID ACCELERATION MEASUREMENT

A method of estimating the lower bound of coronal magnetic field strength in the neighborhood of an ejecting plasmoid is presented. Based on the assumption that the plasma ejecta is within a magnetic island, an analytical expression for the force acting on the ejecta is derived. The method is applied to a limb coronal mass ejection event, and a lower bound of the magnetic field strength just below the CME core is estimated. The method is expected to provide useful information on the strength of reconnecting magnetic field if applied to X-ray plasma ejecta.

Inhibitory effects of extracts from Smilacina japonica on lipopolysaccharide induced nitric oxide and prostaglandin E 2 production in RAW264.7 macrophages

Smilacina japonica is a localized common rhizomatous flowering plant, This plant is often used in Korean traditional systems of medicine as a remedy for migrain, diplegia, physical impurity, blood circulation, abscess and contusion. Generally drugs that are used for arthritis have antinociceptive and anti-inflammatory properties. However, validity of the anti-inflammatory activity has not been scientifically investigated so far. Therefore, the aim of this study was to investigate the anti-inflammatory potential of S. japonica using the ethanolic extract and its sub- fractions. To evaluate the anti-inflammatory effects, we examined the inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2) on RAW 264.7 macrophages. Our results indicated that hexane fraction significantly inhibited the LPS induced NO and PGE2 production in the cells. The hexane fractions inhibitory activity for NO tests with IC50 values showed in 53.3 μg/ml and PGE2 tests with IC50 values showed at 32.5 μg/ml. Theseis result suggest a potential role of hexane fraction from S. japonica as source of anti-inflammatory agent.

In vitro anti-inflammatory activity of extracts from Potentilla supina in murine macrophage RAW 264.7 cells

본 연구에서는 개소시랑개비 (Potentilla supina)의 전초를 이용하여 세포독성 및 항염증 활성 효과를 평가하였다. 대식세포인 RAW264.7 cell에서 염증 매개 물질인 lipopo-lysacchride(LPS)로 염증을 유발해 nitric oxide (NO), Inducible nitric oxide synthase (iNOS)와 prostaglandin

Anti-inflammatory Activity of Peel Extracts in Color-fleshed Potatoes

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Study on Biological Activities and Analysis of Total polyphenol and Isolation of Biological Effective Compounds from Potentilla kleiniana

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Genial tubercle: An anatomical analysis and the implications for genioglossus advancement

PGE_2

Inhibitory Effects of Extracts from Arabis glabra on Lipopolysaccharide Induced Nitric Oxide and Prostaglandin E 2 Production in RAW264.7 Macrophages

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