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Publication
Featured researches published by L. K. Von Segesser.
Swiss Surgery | 2001
X. M. Mueller; Hendrik T. Tevaearai; Claude-Yves Genton; Pascal Chaubert; L. K. Von Segesser
BACKGROUND AND OBJECTIVE Theoretically myocardial angiogenesis of laser injury can be further enhanced by the addition of angiogenic growth factors. The influence of the way of administration of these factors on vascular growth around the channels is still unclear. MATERIALS AND METHODS 18 pigs (mean weight 72 +/- 5.2 kg) were randomized to either triads of transmyocardial laser revascularization (TMLR) channels (group 1, n = 6) or isolated channels (group 2, n = 6), or a control group (n = 6). The animals had injections of bovine bone derived growth factor mixture either in the center of the triads in group 1 or within the channels themselves in group 2. Animals were sacrificed one month later for histological analysis. RESULTS The vascular densities of myocardial areas within the triads of group 1 and around the channels in group 2 were significantly larger than in the control group: 15.2 +/- 3.7/mm2 and 14.2 +/- 3.5/mm2 respectively vs 5.3 +/- 1.6/mm2 (p < 0.001 for both differences). Differences of densities between group 1 and 2 were not statistically significant (p = 0.6). CONCLUSIONS In this porcine model, the addition of a bovine bone derived growth factor mixture to TMLR significantly stimulates angiogenesis in the areas adjacent to the channels. The place of injection does not influence the angiogenesis intensity.
Swiss Surgery | 1998
Hendrik T. Tevaearai; X. M. Mueller; P. Ruchat; M. Hurni; Frank Stumpe; A. Fischer; L. K. Von Segesser
Swiss Surgery | 1998
X. M. Mueller; Hendrik T. Tevaearai; Frank Stumpe; M. Hurni; P. Ruchat; Charles Seydoux; Jean-Jacques Goy; Lukas Kappenberger; L. K. Von Segesser
Swiss Surgery | 2003
Jean-Jacques Goy; Charles Seydoux; Francine Tinguely; M. Hurni; P. Ruchat; Frank Stumpe; A. Fischer; P. Gersbach; A. Corno; X. M. Mueller; René Chioléro; Jean-Pierre Revelly; L. K. Von Segesser
Swiss Surgery | 2001
Hendrik T. Tevaearai; X. M. Mueller; P. Chastoray; J. B. Favre; Patrick Ravussin; Ph. Eckert; Pierre Vogt; Alain Delabays; L. K. Von Segesser; Frank Stumpe
Swiss Surgery | 2000
L. K. Von Segesser
Swiss Surgery | 1999
X. M. Mueller; Hendrik T. Tevaearai; Monique Augstburger; Marco Burki; L. K. Von Segesser
Swiss Surgery | 1998
X. M. Mueller; Hendrik T. Tevaearai; K. Van Ness; Monique Augstburger; L. K. Von Segesser
Swiss Surgery | 1998
P. Ruchat; P. Capasso; D. Hayoz; A. Genton; P. Schnyder; L. K. Von Segesser
Swiss Surgery | 1998
Hendrik T. Tevaearai; X. M. Mueller; L. K. Von Segesser