L. M. Ramondetta

Prospective evaluation of insulin resistance among endometrial cancer patients

OBJECTIVEnObesity and estrogen are strong risk factors for endometrial cancer (EC). Whereas diabetes also increases the risk, little is known about related insulin resistance (IR). The purpose of this study was to determine the prevalence of IR in newly diagnosed EC patients.nnnSTUDY DESIGNnEC patients from a large, metropolitan county were prospectively enrolled from 2005 to 2008. Fasting serum was analyzed for glucose and insulin. IR was defined as a history of diabetes or a quantitative insulin sensitivity check index (QUICKI) (1/[log fasting insulin + log fasting glucose]) value of less than 0.357.nnnRESULTSnAmong 99 patients, diabetes was present in 30, and an abnormal QUICKI was found in 36 additional patients. Increased risk of IR was significantly associated with higher body mass index (P < .001), lower socioeconomic status (P = .007), and nulliparity (P = .029).nnnCONCLUSIONnIR was highly prevalent in endometrial cancer patients, including nonobese women. Better characterization of metabolic risks in addition to obesity may provide avenues for targeted cancer prevention in the future.

Visual analog scale (VAS) and time trade-off (TTO) preferences for side effects (SE) of chemoradiation (chemoXRT): A comparison of patients (pts) and caregivers (CG).

9056 Background: CG provide clinicians valuable information about treatment-related SE they see pts experience. As part of a larger study, we prospectively assessed the preferences of pts and CG fo...

A retrospective analysis of clinical outcomes in patients treated for malignant mixed mesodermal tumors of the ovary and uterus with an evaluation of molecular marker expression

5107 Background: The purpose of this study was to compare molecular marker expression and clinical outcomes in patients treated for malignant mixed mesodermal tumor (MMMT) of the ovary with previou...