L. M. Yagupol'skii

Mefenamic acid — A nonsteroid antiinflammatory agent

The inflammatory process is, as known, a pathological symptom of many illnesses. Therefore, the regulation of the inflammatory reaction, including that by means of pharmacological compounds, is one of the important problems of modern medicine. In particular, medicinal compounds are used in clinics, which inhibit the development of the inflammatory process. The suppression of inflammation makes it possible to shorten the time of the illness and to decrease the gravity of the disease and its consequences.

Preparation and use ofα-bromomono- and-bromobis-difluoromethoxyacetophenones in the synthesis of polymethyleneimidazoles with an angular nitrogen atom

The synthesis of α-bromo-4-difluoromethoxy- and α-bromo-2,4-bis(difluoromethoxy)acetophenones has been carried out. Conditions have been studied for condensing the latter with cyclic tri- and tetramethylenamidinines and with pyridine-containing derivatives. A series of pyrrolo[1,2-a]imidazole and imidazo[2,1-a]pyridine derivatives containing difluoromethoxy groups has been synthesized.

Interaction of functional groups via π-electron systems

Data on the dipole moments of 4,4′-derivatives of diphenyl are used to show that the interaction between the substituents is weakened by a second phenyl ring between them.

A study of the infrared spectra of aryl trifluoromethyl ethers

Summary1.The infrared spectra of seven aryl trifluoromethyl ethers have been obtained and the attribution of the trifluoromethoxy group absorption is discussed. The intense 1262±5 cm−1 (υCarom), 1178±10 cm−1 (νC-F), 1222±4 cm−1 (νc-f), and 925 cm−1 bands can be used in analysis for determining the presence of an OCF3 group in the benzene ring.2.The shifts in the frequencies of theC-F valence vibrations show that transmission of the electron effects of the para substituent on the C-F bond via the ring-heteroatom system diminishes in the order-S->-O->-SO2-.

Investigation of the charge state of heteroatoms in organic compounds of third-row elements by X-ray fluorescence spectroscopy 2. Unexpected influence of the carbanion center in trifluoromethylsulfonyl-containing meisenheimer complexes and phosphorus ylids on the magnitude of the positive charge on the sulfur atom

Conclusions1.An increase in the positive charge on the S atoms of the trifluoromethylsulfonyl groups in anionic Meisenheimer σ complexes and phosphorus ylids in comparison to the corresponding original trifluoromethyl sulfones has been discovered.2.The observed increase in q(S) may be caused by the high degree of polarization of the trifluoromethylsulfonyl group.

Mass spectrometry of the positive and negative ions of α,β-difluorocinnamic acid and some of its p-substituted analogs

Conclusions1.The mass spectra of the positive and negative ions of cis- and trans-α,β-difluorocinnamic acids and some of their derivative were studied. Fluorine atoms decrease the stabilities of these molecules with respect to electron impact.2.The mass spectra of the positive and negative ions of the cis and trans isomers differ and can be used to identify the geometrical isomers of α,β-difluorocinnamic acids.3.Rearrangement processes prevail over processes involving simple bond cleavage under resonance electron-capture conditions.

Synthesis and study of the biological properties of fluorinated derivatives of 1-phenyl-3-methylpyrazol-5-one. Analogs of antipyrine with heteroatomic fluorinecontaining substituents

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REAKTION ALPHA,BETA-DISUBSTITUIERTER STILBENE MIT BLEIDIOXID UND SCHWEFELTETRAFLUORID ODER FLUORWASSERSTOFF

Z50.

FLUORANALOGE VON TERPENEN 2. MITT. SYNTHESE VON ANALOGEN DES P‐MENTHANOLS‐(3) MIT FLUORIERTER ISOPROPYLGRUPPE

Die cis-Stilbene (I) reagieren mit PbO2 und SF4 oder HF (Molverhaltnis wie 1:1:5) in Tetrachlormethan oder Methylenchlorid bei -50 bis -20°C zu den Phenanthrenen (II).

Reaction of SeOCF3 and SeO2CF3 groups with π-electron systems in ground and excited states

Durch Reduktion des Trifluormethylphenylisopropanols (I) mit 57%igem wasrigem HJ in Gegenwart von Pbei 145- 1 50°C und Nitrierung des entstehenden Trifluorcy- mols wird die Nitroverbindung (II) dargestellt und auf ublichem Wege in das Phenol (III) ubergefuhrt.