Lantao Liu

Synthesis of dendrimer-supported ferrocenylmethyl aziridino alcohol ligands and their application in asymmetric catalysis

A series of N-ferrocenylmethyl aziridino alcohol ligands bearing Frechet-type dendrimers were synthesized and applied in the asymmetric addition of diethylzinc to aldehydes affording chiral alcohols in excellent yields (up to 99%) and excellent enantioselectivities (ee, up to 98%). The ligands could be recycled and reused eight times for such a reaction with almost the original high reactivity and selectivity.

An easily available N -heterocyclic carbene–palladium(II) catalyst for Buchwald–Hartwig amination of aryl chlorides

An easily available N-heterocyclic carbene–palladium(II) complex was found to be an efficient catalyst for the Buchwald–Hartwig amination of aryl chlorides. Both secondary and primary amines were tolerated under the same reaction conditions. Under the optimal conditions, all reactions proceeded successfully to give the desired products in good to high yields within hours.Graphical Abstract

Organocatalytic asymmetric synthesis of compounds bearing both isoxazole and pyrazole moieties via 1,6-addition of pyrazol-5-ones to 3-methyl-4-nitro-5-alkenylisoxazoles

An efficient one-pot asymmetric synthesis of chiral compounds containing both isoxazole and pyrazole moieties has been developed. The bifunctional thiourea catalyzed asymmetric 1,6-addition of pyrazol-5-ones to 3-methyl-4-nitro-5-alkenylisoxazoles provided the corresponding acetylated chiral heterocycles after in situ treatment with AcCl/Et3N. The corresponding products were generated in good yields (72–90%) with high enantioselectivities (83–94% ee).

Dinuclear NHC–palladium(II) complexes: synthesis,characterization and application to Suzuki–Miyaura cross-coupling reactions

Four dinuclear N-heterocyclic carbene–palladium(II) complexes 1–4 were prepared and characterized by elemental analysis and spectroscopic methods. The X-ray crystal structure of complex 2 showed a dinuclear framework in which N-heterocyclic ligands bridge between two square planar palladium(II) units. Each palladium center is surrounded by an imidazolylidene, a nitrogen atom from the central linking ligand, and two trans-chloride ligands. These dinuclear NHC–palladium(II) complexes exhibited efficient catalytic activities for the Suzuki–Miyaura coupling of aryl and benzyl chlorides with arylboronic acids.Graphical Abstract