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Larry Wayne Hertel

Eli Lilly and Company

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Publication

Featured researches published by Larry Wayne Hertel.

Bioorganic & Medicinal Chemistry Letters | 2003

Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 3

Kumiko Takeuchi; Todd J. Kohn; Nicholas Allan Honigschmidt; Vincent Patrick Rocco; Patrick Gianpietro Spinazze; Daniel James Koch; Steven T Atkinson; Larry Wayne Hertel; David L. Nelson; D.Bradley Wainscott; Laura J Ahmad; Janice Shaw; David T. Wong

A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT(1A) receptor antagonism and serotonin reuptake inhibition was discovered. 1-(1H-Indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidinyl)propan-2-ols exhibited selective and high affinity at the 5-HT(1A) receptor and serotonin reuptake inhibition at nanomolar concentrations for dual activities.

Synthetic Communications | 1991

Preparation and Storage of (R)-2,3-O-Isopropylideneglyceraldehyde (D-Glyceraldehyde Acetonide)

Larry Wayne Hertel; Cora Sue Grossman; Julian Stanley Kroin

Abstract This is a report on the synthesis and on the storage of D-glyceraldehyde acetonide for as long as three years after initial preparation while retaining its enantiomeric purity.

Cancer Research | 1991

Action of 2′,2′-Difluorodeoxycytidine on DNA Synthesis

Peng Huang; Sherri Chubb; Larry Wayne Hertel; Gerald B. Grindey; William Plunkett

Cancer Research | 1988

Comparison of the Cellular Pharmacokinetics and Toxicity of 2′,2′-Difluorodeoxycytidine and 1-β-d-Arabinofuranosylcytosine

Volker Heinemann; Larry Wayne Hertel; Gerald B. Grindey; William Plunkett

International Journal of Radiation Oncology Biology Physics | 1996

Radiosensitization of pancreatic cancer cells by 2′,2′-difluoro-2′-deoxycytidine

Theodore S. Lawrence; Emily Y. Chang; Tina M. Hahn; Larry Wayne Hertel; Donna S. Shewach

Cancer Research | 1992

Cellular Elimination of 2′,2′-Difluorodeoxycytidine 5′-Triphosphate: A Mechanism of Self-Potentiation

Volker Heinemann; Yi-Zheng Xu; Sherri Chubb; Alina Sen; Larry Wayne Hertel; Gerald B. Grindey; William Plunkett

Cancer Research | 1994

Metabolism of 2′,2′-Difluoro-2′-Deoxycytidine and Radiation Sensitization of Human Colon Carcinoma Cells

Donna S. Shewach; Tina M. Hahn; Emily Y. Chang; Larry Wayne Hertel; Theodore S. Lawrence

Archive | 1987

Difluoro antivirals and intermediate therefor

Larry Wayne Hertel

Archive | 1994

Method of treating tumors in mammals with 2',2'-difluoronucleosides

Gerald B. Grindey; Larry Wayne Hertel

Molecular Pharmacology | 1999

Comparison of the Mechanism of Cytotoxicity of 2-Chloro-9-(2-deoxy-2-fluoro-β-d-arabinofuranosyl)adenine, 2-Chloro-9-(2-deoxy-2-fluoro-β-d-ribofuranosyl)adenine, and 2-Chloro-9-(2-deoxy-2,2-difluoro-β-d-ribofuranosyl)adenine in CEM Cells

William B. Parker; Sue C. Shaddix; Lucy M. Rose; Donna S. Shewach; Larry Wayne Hertel; John A. Secrist; John A. Montgomery; L. Lee Bennett

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Julian Stanley Kroin

Eli Lilly and Company

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Cora Sue Grossman

Eli Lilly and Company

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Gerald B. Grindey

Eli Lilly and Company

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Charles David Jones

Eli Lilly and Company

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Thomas Edward Mabry

Eli Lilly and Company

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Richard Elmer Holmes

Eli Lilly and Company

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Ta-Sen Chou

Eli Lilly and Company

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Douglas Patton Kjell

Eli Lilly and Company

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Laurie Michelle Poteet

Eli Lilly and Company

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William Plunkett

University of Texas MD Anderson Cancer Center

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