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Featured researches published by Lars Flataker.


Experimental Biology and Medicine | 1956

Effects of Lysergic Acid Diethylamide upon Performance of Trained Rats

Charles A. Winter; Lars Flataker

Summary 1) A syndrome resulting from intraperitoneal injection of LSD in rats is described. In rats trained to climb a rope, LSD produces signs of confusion and markedly prolongs climbing time. This effect on climbing time can be objectively and quantitatively measured, and is linearly related to the log dose of LSD. 2) Effects of LSD could be partially antagonized by serotonin or by 5-hydroxy tryptophane administered intra-peritoneally. α-4 (piperidyl) benzhydrol did not affect the action of LSD, while reserpine intensified and prolonged the LSD-syndrome.


Experimental Biology and Medicine | 1952

Antitussive Action of d-Isomethadone and d-Methadone in Dogs

Charles A. Winter; Lars Flataker

Summary A method is described for testing antitussive activity in dogs. It is shown that 2 compounds nearly devoid of analgesic or narcotic properties, d-methadone and d-isomethadone, are active in this test.


Experimental Biology and Medicine | 1952

Effect of steroids upon resistance of skin to intracutaneous injection.

Charles A. Winter; Lars Flataker

Summary 1. Measurements have been made of the resistance offered by the skin to the intracutaneous introduction of fluid, as determined by the amount of pressure required to perform an intracutaneous injection under carefully controlled conditions in adult male rats. 2. Systemic administration of cortisone markedly increased the resistance of the skin to injection. Hyaluronidase, incorporated in the fluid administered intracutaneously, lowered the injection pressure. The effect of cortisone, however, was shown to be independent of the effect of the steroid upon hyaluronidase. Testosterone, desoxycorticosterone, compound S, and 21-acetoxypregnenolone were without effect under the conditions of these experiments.


Journal of Pharmacology and Experimental Therapeutics | 1965

REACTION THRESHOLDS TO PRESSURE IN EDEMATOUS HINDPAWS OF RATS AND RESPONSES TO ANALGESIC DRUGS

Charles A. Winter; Lars Flataker


Journal of Pharmacology and Experimental Therapeutics | 1951

THE EFFECT OF CORTISONE, DESOXYCORTICOSTERONE, AND ADRENOCORTICOTROPHIC HORMONE UPON THE RESPONSES OF ANIMALS TO ANALGESIC DRUGS

Charles A. Winter; Lars Flataker


Journal of Pharmacology and Experimental Therapeutics | 1965

NOCICEPTIVE THRESHOLDS AS AFFECTED BY PARENTERAL ADMINISTRATION OF IRRITANTS AND OF VARIOUS ANTINOCICEPTIVE DRUGS

Charles A. Winter; Lars Flataker


Journal of Pharmacology and Experimental Therapeutics | 1950

STUDIES ON HEPTAZONE (6-MORPHOLINO-4, 4-DIPHENYL-3-HEPTANONE HYDROCHLORIDE) IN COMPARISON WITH OTHER ANALGESIC DRUGS

Charles A. Winter; Lars Flataker


Journal of Pharmacology and Experimental Therapeutics | 1954

ANTITUSSIVE COMPOUNDS: TESTING METHODS AND RESULTS

Charles A. Winter; Lars Flataker


Journal of Pharmacology and Experimental Therapeutics | 1951

THE EFFECT OF ANTIHISTAMINIC DRUGS UPON THE PERFORMANCE OF TRAINED RATS

Charles A. Winter; Lars Flataker


Journal of Nervous and Mental Disease | 1958

Effect of Blood Plasma from Psychotic Patients upon Performance of Trained Rats

Charles A. Winter; Lars Flataker

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