Lars H. Hellberg

Synthesis of the spirocyclic alkaloid nitramine

Abstract The alkaloid nitramine was prepared in a four operation process using reductive cyclization of a γ-cyano ester to a spirolactam as a key step.

Synthesis of Deuterium-Labeled Antihypertensive 3-(4-Phenyl-1′-Piperazinyl)-Propyl-2,4-Quinazolinedione

Abstract Synthesis of deuterium-labeled 3-(4-phenyl-1-piperazinyl)-propyl-2,4-quinazolinedione (Pelanserine) an anti-hypertensive agent.

Triphosgene/Triphenylphosphine: A Mild Reagent for the Conversion of Alcohols to Chlorides

Abstract A mixture of triphosgene/triphenylphosphine in methylene chloride converts primary and secondary alcohols to chlorides at room temperature.

Synthesis of Tuberine

Abstract Tuberine, has been synthesized by syn sulfoxide elimination to introduce the enamide function.

Improved Syntheses of Peptide Coupling Reagents Bop and PyBOP Using Triphosgene

Abstract Synthesis of Benzotriazolyloxy tris [dimethyl-amino] phosphonium hexafluorophosphate (BOP) and Benzotriazolyloxy tris [pyrrolidino] phosphonium hexafluorophosphate (PyBOP), using triphosgene and hydroxybenzotriazole.

CONVENIENT SYNTHESIS OF 1-OXA-3,8-DIAZASPIRO 4,5 DECAN-2-ONES

Abstract Synthesis of 1-oxa-3,8-diazospiro [4,5] decan-2-ones from 4-pyridone by addition of trimethylsilyl cyanide.

Synthesis of 3-Dipeptidyl-2,4(1H,3H)-Quinazolinediones as Potential Anti-Hypertensive Agents

Abstract Quinazolinediones bearing a dipeptide side chain have been synthesized as potential anti-hypertensive agents.

PARTIAL DEPROTECTION OF 1.2.5.6-DI-O-ISOPROPYLIDENE-D-GLUCOFURANOSES

Die selektive Entfernung der 5,6-O-Isopropylidengruppe der Di-O-isopropyliden-D-glucofuranosen (I) zur Herstellung der Mono-isopropyliden-D-glucofuranosen (II) wird beschrieben.

Thermal cyclisation of β-hydroxyamides to oxazolines

Thermal conversion is described of amides derived from erythro and threo ephedrines yields stereospecific oxazolines.

Synthesis of Z‐N‐Alkenylformamides

Abstract Commercially available difluorinated benzaldehyde was converted to the Z‐N‐alkenylformamides via Horner–Emmons olefination and Curtius rearrangement, followed by reduction with tri‐tert‐butoxy‐aluminohydride.