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Dive into the research topics where Laurens Holmes is active.

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Featured researches published by Laurens Holmes.


American Journal of Sports Medicine | 2014

Stress Sonography of the Ulnar Collateral Ligament of the Elbow in Professional Baseball Pitchers A 10-Year Study

Michael G. Ciccotti; Alfred Atanda; Levon N. Nazarian; Christopher C. Dodson; Laurens Holmes; Steven B. Cohen

Background: An injury to the ulnar collateral ligament (UCL) of the elbow is potentially career threatening for elite baseball pitchers. Stress ultrasound (US) of the elbow allows for evaluation of both the UCL and the ulnohumeral joint space at rest and with stress. Hypothesis: Stress US can identify morphological and functional UCL changes and may predict the risk of a UCL injury in elite pitchers. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 368 asymptomatic professional baseball pitchers underwent preseason stress US of their dominant and nondominant elbows over a 10-year period (2002-2012). Stress US examinations were performed in 30° of flexion at rest and with 150 N of valgus stress by a single musculoskeletal radiologist. Ligament thickness, ulnohumeral joint space width, and ligament abnormalities (hypoechoic foci and calcifications) were documented. Results: There were 736 stress US studies. The mean UCL thickness in the dominant elbow (6.15 mm) was significantly greater than that in the nondominant elbow (4.82 mm) (P < .0001). The mean stressed ulnohumeral joint space width in the dominant elbow (4.56 mm) was significantly greater than that in the nondominant elbow (3.72 mm) (P < .02). In the dominant arm, hypoechoic foci and calcifications were both significantly more prevalent (28.0% vs 3.5% and 24.9% vs 1.6%, respectively; P < .001). In the 12 players who incurred a UCL injury, there were nonsignificant (P > .05) increases in baseline ligament thickness, ulnohumeral joint space gapping with stress, and incidence of hypoechoic foci and calcifications. More than 1 stress US examination was performed in 131 players, with a mean increase of 0.78 mm in joint space gapping with subsequent evaluations. Conclusion: Stress US indicates that the UCL in the dominant elbow of elite pitchers is thicker, is more likely to have hypoechoic foci and/or calcifications, and has increased laxity with valgus stress over time.


Spine | 2014

The effect of serial growing rod lengthening on the sagittal profile and pelvic parameters in early-onset scoliosis

Suken A. Shah; Ali F. Karatas; Arjun A. Dhawale; Ozgur Dede; Gregory M. Mundis; Laurens Holmes; Petya Yorgova; Geraldine Neiss; Charles E. Johnston; John B. Emans; George H. Thompson; Jeff Pawelek; Behrooz A. Akbarnia

Study Design. Retrospective case series. Objective. To report the effect of repeated growing rod (GR) lengthenings on the sagittal and pelvic profile in patients with early-onset scoliosis. Summary of Background Data. Posterior distraction-based GRs have gained popularity as a technique for the surgical management of early-onset scoliosis. However, there are no published studies on the effect of serial GR lengthenings on sagittal balance, thoracic kyphosis (TK), lumbar lordosis (LL), and pelvic parameters. Methods. We retrospectively reviewed data from a multicenter early-onset scoliosis database. Forty-three patients who were able to walk with minimum 2-year follow-up who underwent single- or dual-GR surgery were included for review. Mean number of lengthenings was 6.4 (range, 3–16). Mean preoperative age was 5.6 years (standard deviation, 2.4 yr), and mean follow-up was 3.5 years. Maximum TK, LL, and sagittal balance were assessed preoperatively, after index surgery, and at the latest follow-up. Results. There was a significant decrease both in TK and LL after index surgery, which then increased during the lengthening period. There was a significant increase in both proximal junctional kyphosis and distal junctional angle. Pelvic parameters (pelvic tilt, pelvic incidence, sacral slope) were unchanged during the treatment period. Significant improvement was observed in sagittal balance. There was a correlation between the change in TK and change in LL. Conclusion. TK decreased after index surgery and increased between the index surgery and the latest follow-up, which was accompanied by an increase in LL. All-screw proximal constructs had mean 9° more proximal junctional kyphosis than all-hook proximal constructs. An increase in proximal junctional kyphosis and distal junctional angle was found during the treatment period. Although there was an independent effect of number of lengthenings on TK, there was no significant detrimental effect on other sagittal spinopelvic parameters. GRs had a positive effect on sagittal vertical axis, which returned patients to a more neutral alignment through the course of treatment. Level of Evidence: 4


Journal of Bone and Joint Surgery-british Volume | 2013

Long-term outcome of reconstruction of the hip in young children with cerebral palsy

Arjun A. Dhawale; Ali F. Karatas; Laurens Holmes; Kenneth J. Rogers; Kirk W. Dabney; Freeman Miller

We reviewed the long-term radiological outcome, complications and revision operations in 19 children with quadriplegic cerebral palsy and hip dysplasia who underwent combined peri-iliac osteotomy and femoral varus derotation osteotomy. They had a mean age of 7.5 years (1.6 to 10.9) and comprised 22 hip dislocations and subluxations. We also studied the outcome for the contralateral hip. At a mean follow-up of 11.7 years (10 to 15.1) the Melbourne cerebral palsy (CP) hip classification was grade 2 in 16 hips, grade 3 in five, and grade 5 in one. There were five complications seen in four hips (21%, four patients), including one dislocation, one subluxation, one coxa vara with adduction deformity, one subtrochanteric fracture and one infection. A recurrent soft-tissue contracture occurred in five hips and ten required revision surgery. In pre-adolescent children with quadriplegic cerebral palsy good long-term outcomes can be achieved after reconstruction of the hip; regular follow-up is required.


Spine deformity | 2013

Ponte Osteotomies With Pedicle Screw Instrumentation in the Treatment of Adolescent Idiopathic Scoliosis

Suken A. Shah; Arjun A. Dhawale; Jon E. Oda; Petya Yorgova; Geraldine Neiss; Laurens Holmes; Peter G. Gabos

STUDY DESIGNnReview of prospective database.nnnOBJECTIVESnTo report the results of Ponte osteotomy with pedicle screw instrumentation for major thoracic adolescent idiopathic (AIS) curves.nnnSUMMARY OF BACKGROUND DATAnPonte osteotomy for achieving coronal and sagittal correction of major thoracic curves in AIS with pedicle screw instrumentation is a widespread technique, but results have not been well described.nnnMETHODSnReview of 87 consecutive AIS patients with Lenke 1-4 curves who underwent Ponte osteotomies and pedicle screw instrumentation by 2 surgeons at a single institution. Surgical details, blood loss, and complications were recorded. We evaluated coronal and sagittal radiological measurements and Scoliosis Research Society-22 (SRS-22) questionnaire scores over 2-year follow-up.nnnRESULTSnThe mean preoperative thoracic coronal Cobb angle was 57° ± 9.7°, fulcrum flexibility was 47.2%, and lateral Cobb angle was 17.8° ± 4°. The mean estimated blood loss (EBL), expressed as percent estimated blood volume, was 35.8 ± 20.5 mL. There was significant improvement in coronal thoracic Cobb angle, percent correction, and apical vertebral translation over 2-year follow-up (pxa0<xa0.05). In hypokyphotic curves, there was a significant increase in lateral thoracic T5-T12 kyphosis from 8.1° to 18.3° (p < .001). In hyperkyphotic curves, mean lateral thoracic T5-T12 kyphosis improved from 45° to 26° (p < .001). Median SRS-22 domains were higher after treatment (p < .05). Complications included significant hypotension (1), EBL greater than 75% estimated blood volume (2), and wound infection needing drainage (2). There were neuromonitoring signal changes in 7 patients but no significant neurological complications.nnnCONCLUSIONSnIn this case series of major thoracic AIS curves treated with segmental pedicle screw instrumentation and Ponte osteotomies, there was an improvement in the coronal and sagittal radiological parameters. A prospective controlled study is needed to determine whether pedicle screw instrumentation and Ponte osteotomies influence outcomes and complications.


Gait & Posture | 2012

Correlation of radiographic and pedobarograph measurements in planovalgus foot deformity.

Muayad Kadhim; Laurens Holmes; Freeman Miller

Planovalgus foot deformity is common in children with cerebral palsy. Several pathologies contribute to the deformity. It begins with the lateral displacement of the navicular and the talar head becomes uncovered and prominent in the medial side of the midfoot. The purpose of this study was to assess the correlation between the radiographic and the pedobarographic measurements and the ability to predict foot pressure components using radiographic measurement. The patient sample included 43 patients with cerebral palsy who were ambulatory and had planovalgus foot deformity (76 feet). Medial midfoot pressure showed correlation with talonavicular uncoverage index, talonavicular angle, medial arch angle, Meary angle, and lateral talocalcaneal angle. Heel impulse showed negative correlation with talonavicular uncoverage index and talonavicular angle. Simple linear regression was used to assess the relationship between radiographic and foot pressure component measurements. For every unit change in talonavicular uncoverage index, the predicted value of medial midfoot pressure was [9.9+27 (talonavicular uncoverage index)]. This equation accounted for 17.9% of the changes in the medial midfoot pressure. Tibial foot angle and maximum knee extension also contributed to the heel impulse. The radiographic indices of the planovalgus foot can explain the changes in some foot pressure components.


The Spine Journal | 2014

The role of magnetic resonance imaging in acute cervical spine fractures

Sina Pourtaheri; Arash Emami; Kumar Sinha; Michael Faloon; Ki S. Hwang; Eiman Shafa; Laurens Holmes

BACKGROUND CONTEXTnThe role of magnetic resonance imaging (MRI) in neurologically intact cervical spine fractures is not well defined. To our knowledge, there are no studies that clearly identify the indications for MRI in this particular scenario. Controversy remains regarding the use of MRI in at-risk patients, primarily the obtunded and elderly patients.nnnPURPOSEnThe purpose of the present study was to examine the predisposing conditions where an MRI would provide additional findings that would affect management in acute cervical spine fractures.nnnSTUDY DESIGNnRetrospective cohort involving radiographic and clinical review.nnnPATIENT SAMPLEnConsecutive patients with acute cervical injuries at a single institution.nnnOUTCOME MEASURESnNeurologic recovery.nnnMETHODSnA review of 830 patients with cervical spinal injuries between 2006 and 2010 was performed. Clinical information was obtained for all the patients: Glasgow Coma Scale, mechanism of injury, major medical comorbidities, associated injuries, neurologic examination, neurologic symptoms, sex, age, and alertness. Two experienced fellowship-trained spine surgeons determined if the MRI study changed the management in the individual cases based on the Sub-axial Cervical Spine Injury classification system.nnnRESULTSnNinety-nine patients with a cervical fracture were included in the final analysis: median age 54 years (interquartile range, 42 years), mean Glasgow Coma Scale 13 (standard deviation ± 3.0), 68% males, 32% females, 42% older patients (age>60 years), 30% spondylosis, 27% polytrauma, 67% alert, 28% neurologic deficit. Major medical comorbidities, prior to injury level of activity, atlantoaxial versus subaxial, and gender were not associated with changes in diagnosis and management (p>.05). Age >60 years, neurologic deficit, polytrauma status, alertness, and spondylosis were associated with having additional clinically relevant findings seen on MRI and changes in management (p<.05). The majority of the changes in management were related to MRIs illustration of the spinal cord injury and not due to an occult instability. Eighty-one percent of the changes in management were related to the depiction of the spinal cord compression seen on MRI, whereas 19% of the changes in management were related to occult instability seen on MRI.nnnCONCLUSIONSnOlder age (>60 years), obtunded or temporary non-assessable status, cervical spondylosis, polytrauma, and neurologic deficit are predisposing factors for further injury found on MRI but missed on computed tomographic scan alone. These additional findings can affect the management in acute cervical spine fractures. The rational of the on-call spine surgeon to order an MRI for a cervical spine fracture is well founded and often that MRI will affect the fracture management. Magnetic resonance imaging particularly helps with better defining the type of spinal cord compression. Picking up occult instability missed on computed tomographic scan was possible with MRI but not as common.


Journal of Foot & Ankle Surgery | 2013

Long-term Outcome of Planovalgus Foot Surgical Correction in Children with Cerebral Palsy

Muayad Kadhim; Laurens Holmes; Freeman Miller

Pes planovalgus deformity results from changes in the anatomic relations among tarsal bones. Foot deformity and pain can affect the patients ability to ambulate and are common indications for surgery. The present study was a retrospective study aimed at assessing the effectiveness and complications of subtalar fusion and calcaneal lengthening during long-term follow-up in ambulatory children with cerebral palsy. Pedobarographic measurements, ankle range of motion, and radiographic indexes were used to assess the outcome of surgery. The functional abilities of the patients were assessed using the gross motor functional classification system. Pain complaints were reported to evaluate potential risk factors. A total of 24 patients (43 feet) were included, with mean age at surgery of 11 ± 3.2 (range 4.7 to 18.3) years and mean follow-up duration of 10.9 ± 2.7 (range 6.3 to 15.4) years. Of the 43 feet, 15 were treated with calcaneal lengthening (mostly gross motor functional classification system level I and II) and 28 with subtalar fusion (mostly gross motor functional classification system level III and IV). Improvement was observed in both surgery groups during long-term follow-up. The need for additional surgery was observed more among patients with poor ambulation who were treated with subtalar fusion. Young patients who underwent surgery were more likely to develop foot pain. Foot pain was less common among children with poor functional abilities and patients who underwent subtalar fusion. Surgical correction of planovalgus deformity has good outcomes after both subtalar fusion and calcaneal lengthening, with maintenance of the deformity correction during long-term follow-up.


Journal of Children's Orthopaedics | 2011

Recurrence after surgery for equinus foot deformity in children with cerebral palsy: assessment of predisposing factors for recurrence in a long-term follow-up study

Sun Young Joo; Durga N. Knowtharapu; Kenneth J. Rogers; Laurens Holmes; Freeman Miller

BackgroundDespite the large number of studies on the recurrence after surgery for equinus foot deformity in cerebral palsy (CP) patients, only a few investigations have reported long-term recurrence rates. Furthermore, little is known on the interval between the recurrent surgeries and the factors that lead to early recurrence. This study aimed to assess the overall recurrence after surgery for equinus foot deformity in patients with CP and to assess the factors associated with recurrence. We also aimed to determine the predisposing factors for early recurrence.MethodsThe medical records of 186 patients (308 feet) were reviewed in order to determine the recurrence after surgery for equinus foot deformity. The type of CP, type of surgery, age at surgery, functional mobility, passive dorsiflexion of the ankle at the last follow-up visit, and subsequent treatment were recorded. Kaplan–Meier survival analysis was employed, with the end point defined as reoperation.ResultsThe mean age at surgery was 6.8xa0±xa02.5xa0years (range, 2.2–13.1). With the mean follow-up period of 11.3xa0years (range, 7.2–17.7), the overall recurrence rate was 43.8%. The recurrence rate was highest among patients with hemiplegia (62.5%). The Kaplan–Meier survival without repeat surgery estimate was shown to be 88.6% at 5xa0years and 59.6% at 10xa0years. Among children with hemiplegia and diplegia, the younger children (≤8xa0years of age) showed a higher rate of recurrence compared with the older children (Pxa0=xa00.04 and Pxa0=xa00.01, respectively). In 41 feet (30.4%), reoperations were performed within 5xa0years after the primary surgery. Early recurrence was most prevalent among children with hemiplegia (50.0%). In children with diplegia and quadriplegia, the younger children underwent the secondary operation later than the older children (Pxa0=xa00.04 and Pxa0=xa00.02, respectively).ConclusionRecurrence after surgery for equinus foot deformity is common and the age at surgery has a significant influence on recurrence. Recurrence can occur at any age while the child is still growing; therefore, it is advised to follow those patients until they reach skeletal maturity.Level of EvidenceLevel III, therapeutic study.


Journal of Children's Orthopaedics | 2014

Treatment of unicameral bone cyst: systematic review and meta analysis.

Muayad Kadhim; Mihir M. Thacker; Amjed Kadhim; Laurens Holmes

PurposeDifferent treatment modalities have been utilized to treat unicameral bone cyst (UBC), but evidence has not been fully described to support one treatment over another and the optimal treatment is controversial. The aim of this quantitative systematic review was to assess the effectiveness of different UBC treatment modalities.MethodsWe utilized Pubmed to isolate retrospective studies on patients with UBC who received any kind of treatment. The included studies needed to have a minimum sample size of 15 patients, and have provided data on radiographic healing outcome.ResultsSixty-two articles were selected for the meta-analysis from a total of 463 articles. The cumulative sample size was 3,211 patients with 3,217 UBC, and male to female ratio was 2.2:1. The summary or pool estimate of methylprednisolone acetate (MPA) injection resulted in a healing rate of (77.4xa0%) that was comparable to bone marrow injection (77.9xa0%). A higher healing rate was observed with MPA injection when inner wall disruption was performed. The pool estimate of bone marrow with demineralized bone matrix injection was high (98.7xa0%). UBC healing rate after surgical curettage was comparable whether autograft or allograft was utilized (90xa0%). UBC treatment with flexible intramedullary nails without curettage provided almost 100% healing rate, while continuous decompression with cannulated screws provided 89xa0% healing rate. Conservative treatment indicated a healing rate of 64.2, 95xa0% CI (26.7–101.8).ConclusionsActive treatment for UBC provided variable healing rates and the outcomes were favorable relative to conservative treatment. Due to the heterogeneity of the studies and reporting bias, the interpretation of these findings should be handled with caution.


Journal of Children's Orthopaedics | 2012

Pes planovalgus deformity surgical correction in ambulatory children with cerebral palsy.

Muayad Kadhim; Laurens Holmes; Chris Church; John Henley; Freeman Miller

PurposePlanovalgus foot deformity is common in diplegic and quadriplegic patients. Surgery is the definitive treatment to restore the alignment of the talus, calcaneus, and navicular bones. We aimed, in the current study, to compare the effectiveness of subtalar fusion and calcaneal lengthening, and to assess the recurrence in ambulatory children with cerebral palsy.MethodsThis is a retrospective study of 78 patients (138 feet diagnosed with planovalgus deformity) who underwent surgical correction using subtalar fusion or calcaneal lengthening. Range of motion, radiographic indices, kinematic, and pedobarographic data were used to examine the deformity and the outcome of surgery. A repeated measures analysis of variance (ANOVA) was used to test the study hypothesis.ResultsMost of the patients were diplegic (87.2xa0%) and the mean age at surgery was 11.9xa0±xa02.9xa0years (range from 4.7 to 18.3xa0years), with a mean follow-up of 5xa0±xa04.4xa0years (range from 1 to 15.4xa0years). Sixty-three feet were treated with calcaneal lengthening, while 75 were treated with subtalar fusion. The feet treated with subtalar fusion were more severe preoperatively. However, both surgery groups showed improvement postoperatively. Among 12 cases of recurrence, medial column fusion was the main surgery performed to correct the deformity.ConclusionsSurgery is effective in the treatment of planovalgus deformity in ambulatory children with cerebral palsy. Severe and rigid planovalgus feet can be treated effectively with subtalar fusion. Feet with milder deformity show good results, with calcaneal lengthening. Surgery provides good correction in young patients, but there is a higher recurrence rate.

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Dive into the Laurens Holmes's collaboration.

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Freeman Miller

Alfred I. duPont Hospital for Children

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Suken A. Shah

Alfred I. duPont Hospital for Children

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Arjun A. Dhawale

Alfred I. duPont Hospital for Children

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Kenneth J. Rogers

Alfred I. duPont Hospital for Children

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Kirk W. Dabney

Alfred I. duPont Hospital for Children

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Muayad Kadhim

Alfred I. duPont Hospital for Children

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Geraldine Neiss

Alfred I. duPont Hospital for Children

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Peter G. Gabos

Alfred I. duPont Hospital for Children

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Petya Yorgova

Alfred I. duPont Hospital for Children

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