Laurent Alain Gabriel Picard

G protein-coupled receptor microarrays for drug discovery.

The dominance of G protein-coupled receptors (GPCRs) as a drug target class, coupled with the increased pace of target identification and expansion of compound libraries, presents a compelling need to develop technologies to screen multiple GPCRs simultaneously. To address this need, GPCR microarrays that require the co-immobilization of lipid molecules and the probe receptors of interest have been fabricated, using conventional robotic printing technologies. Assays to screen compounds for their pharmacological properties (binding affinity, relative potency and selectivity) using GPCR microarrays are discussed.

Novel Surface Technologies for Genomics, Proteomics, and Drug Discovery

Following the recent progress in functional genomics and proteomics, and high-throughput screening (HTS) in drug discovery, evolving technologies over the last decade have offered a tremendous leap over the caveats of traditional techniques. In response to this metamorphosis of technologies through different platforms, Corning has introduced a suite of surface technologies with applications in microarray printing, enhanced attachment, and consumables in drug discovery. Microarrays generated on an ultra-flat glass substrate with GAPS coating exhibiting a robust chemistry and low surface background have led to higher sensitivity and reproducibility for the expression assay. Recent introduction of UltraGAPS™ surface enables oligo attachment for use in differential gene expression analysis. Various attachment surfaces to meet the needs of the applications in genomics, proteomics and drug discovery will be discussed.