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Featured researches published by Leah B. Edwards.


Journal of Heart and Lung Transplantation | 2012

The registry of the international society for heart and lung transplantation: 29th official adult heart transplant report-2012

Josef Stehlik; Leah B. Edwards; Anna Y. Kucheryavaya; Christian Benden; Jason D. Christie; Anne I. Dipchand; Fabienne Dobbels; Richard Kirk; Axel Rahmel; Marshall I. Hertz

This 29th adult transplant report is based on data submitted by 394 transplant centers worldwide. In excess of 104,000 heart transplants have been registered in the database. Summary data are provided for the entire cohort of patients, whereas a number of additional analyses focus on cohorts of patients transplanted more recently. Detailed data analyses can be viewed on the slide set of the registry of the International Society for Heart and Lung Transplantation (ISHLT), which is available online (www.ishlt.org/registries). The report is divided into several sections. Baseline donor, recipient and medical center demographics are reviewed first. The second part focuses on immunosuppressive therapies and acute allograft rejection. Survival after heart transplant is examined next, and data on post-transplant morbidities and quality of life after transplant conclude the report.


Journal of Heart and Lung Transplantation | 2006

Registry of the International Society for Heart and Lung Transplantation: Twelfth Official Pediatric Heart Transplantation Report-2009

Richard Kirk; Leah B. Edwards; Paul Aurora; David O. Taylor; Jason D. Christie; Fabienne Dobbels; Anna Y. Kucheryavaya; Axel Rahmel; Josef Stehlik; Marshall I. Hertz

he ISHLT Registry data are provided by individual enters or a data-sharing arrangement with a national or egional organ procurement or exchange organization. pproximately 450 pediatric heart transplants are reorted to the Registry each year. Most the data are rovided from North American centers, but significant ontributions come from centers in Europe and the rest f the world (Figure 1). The Registry Committee is ctively seeking participation from all centers performng pediatric heart transplants. The tables and figures in this report and additional lides are all available from the ISHLT Web site. ontributing centers are recognized in the Introduction o the 2009 Annual Reports. Survival rates were calculated using the Kaplan-Meier ethod and compared using the log-rank test. Multivaiable analyses were performed using Cox proportional azard regression analysis. Results of the multivariable nalyses are reported as relative risks (RR) with a orresponding p-value or 95% confidence interval, or oth. A RR significantly 1 indicate that the factor is


Journal of Heart and Lung Transplantation | 2014

The Registry of the International Society for Heart and Lung Transplantation: Thirty-first Official Adult Heart Transplant Report—2014; Focus Theme: Retransplantation

Lars H. Lund; Leah B. Edwards; Anna Y. Kucheryavaya; Christian Benden; Jason D. Christie; Anne I. Dipchand; Fabienne Dobbels; Samuel Goldfarb; B. Levvey; Bruno Meiser; Roger D. Yusen; Josef Stehlik

Data are submitted to the International Society for Heart and Lung Transplantation (ISHLT) Registry by national and multinational organ and data exchange organizations or by participating individual centers. Since the Registry inception, 416 heart transplant centers, 241 lung transplant centers, and 168 heart-lung transplant centers have reported data to the registry. We estimate that data submission to the Registry represents approximately 66% of worldwide thoracic transplant activity. This report used standard statistical methodology for analyses and reporting. Where appropriate, a more detailed explanation about the analytic methodology accompanies the Web site slides (in the “Notes Page” view). To assess time-to-event rates (e.g., survival), this report used the


Journal of Heart and Lung Transplantation | 2012

The Registry of the International Society for Heart and Lung Transplantation: 29th Adult Lung and Heart-Lung Transplant Report—2012

Jason D. Christie; Leah B. Edwards; Anna Y. Kucheryavaya; Christian Benden; Anne I. Dipchand; Fabienne Dobbels; Richard Kirk; Axel Rahmel; Josef Stehlik; Marshall I. Hertz

This section of the 29th official International Society for Heart and Lung Transplantation (ISHLT) Registry report summarizes the current status of adult lung and heart-lung transplantation by reporting data on this international group of patients. The Registry contains data on 3,631 adult heart-lung and 39,835 adult lung transplants performed through June 30, 2011 from centers around the world. More detailed information is presented in the full slide set, which is available on the ISHLT Web site at www.ishlt.org/registries/.


Journal of Heart and Lung Transplantation | 2011

The Registry of the International Society for Heart and Lung Transplantation: Twenty-eighth Adult Heart Transplant Report—2011

Josef Stehlik; Leah B. Edwards; Anna Y. Kucheryavaya; Christian Benden; Jason D. Christie; Fabienne Dobbels; Richard Kirk; Axel Rahmel; Marshall I. Hertz

This Twenty-eighth Report of the International Society for Heart and Lung Transplantation (ISHLT) Transplant Registry is based on data submitted by participating transplant centers worldwide. A total of 388 heart transplant centers have contributed information to the Registry. This year we have also achieved another important milestone: the 100,000 heart transplant recipient was registered in the database. This report reviews important statistics for the entire cohort of patients registered in the database. However, similar to prior reports, many of the more detailed analyses will focus on recent transplant recipients, exploring information relevant to contemporary heart transplantation practice. The first part of the report reviews important donor, recipient, and medical center demographics. The second part provides an overview of immunosuppressive therapies used after transplantation. The third part examines survival, mortality risk factors, and causes of death after adult heart transplantation. The last section focuses on quality of life after transplant.


Journal of Heart and Lung Transplantation | 2013

The Registry of the International Society for Heart and Lung Transplantation: Thirtieth Official Adult Heart Transplant Report—2013; Focus Theme: Age

Lars H. Lund; Leah B. Edwards; Anna Y. Kucheryavaya; Anne I. Dipchand; Christian Benden; Jason D. Christie; Fabienne Dobbels; Richard Kirk; Axel Rahmel; Roger D. Yusen; Josef Stehlik

This 30th adult heart transplant report is based on data submitted on 110,486 heart transplants in recipients of all ages (including 99,008 adults) by 407 centers worldwide since 1982 through June 30, 2012, with follow-up until June 30, 2012. Summary data are provided for the entire cohort of patients, whereas a number of additional analyses focus on cohorts who received transplants more recently. Detailed data analyses can be viewed in the International Society for Heart and Lung Transplantation (ISHLT) Registry slide sets available online (www.ishlt.org/registries). The report is divided into several sections:


Journal of Heart and Lung Transplantation | 2013

The Registry of the International Society for Heart and Lung Transplantation: Thirtieth Adult Lung and Heart-Lung Transplant Report—2013; Focus Theme: Age

Roger D. Yusen; Jason D. Christie; Leah B. Edwards; Anna Y. Kucheryavaya; Christian Benden; Anne I. Dipchand; Fabienne Dobbels; Richard Kirk; Lars H. Lund; Axel Rahmel; Josef Stehlik

This section of the 30th official Registry report of 2013 summarizes data from 43,428 adult lung and 3,703 adult heart-lung transplant recipients and their donors for transplants that occurred through June 30, 2012. This report describes donor and recipient characteristics, transplant type, and recipient outcomes data. The full Registry slide set available online (www.ishlt.org/registries) provides more detail, additional analyses, and other information not included in this printed report. For the first time, the Registry report focuses on an overall theme of recipient and donor age and incorporates new age-related analyses into its annual update.


Journal of Heart and Lung Transplantation | 2003

Mechanical circulatory support device database of the international society for heart and lung transplantation: first annual report—2003

Mario C. Deng; Leah B. Edwards; Marshall I. Hertz; Amanda W. Rowe; Robert L. Kormos

Over the last 2 decades, mechanical circulatory support devices have been developed with the goal of supporting patients with advanced heart failure as a bridge to cardiac transplantation, a bridge to recovery, and an alternative to transplantation (also called chronic or destination therapy). The current generation of devices provides a differentiated spectrum of circulatory support. The major limitations of mechanical circulatory support devices are infection, coagulopathies and device dysfunction. The Scientific Council on Mechanical Circulatory Support of the International Society for Heart and Lung Transplantation has established an international database to generate critical data to advance knowledge about the effectiveness of mechanical circulatory support device therapy for one of the most difficult and costly contemporary medical problems, the malignant syndrome of advanced heart failure.


Journal of Heart and Lung Transplantation | 2011

The Registry of the International Society for Heart and Lung Transplantation: Twenty-eighth Adult Lung and Heart-Lung Transplant Report--2011

Jason D. Christie; Leah B. Edwards; Anna Y. Kucheryavaya; Christian Benden; Fabienne Dobbels; Richard Kirk; Axel Rahmel; Josef Stehlik; Marshall I. Hertz

The Registry of the International Society for Heart and Lung Transplantation (ISHLT) has documented trends in clinical lung and heart-lung transplantation since the inception of these procedures. Detailed heart-lung transplantation data have been included in the Registry annual reports since 1984 and lung transplantation data since 1989. Through June 30, 2010, the Registry contains data on 4,248 heart-lung and 38,119 lung transplants from centers around the world. This 28th Lung and Heart-Lung Registry Report summarizes the current status of lung and heart-lung transplantation by reporting data on this international group of patients, focusing on adults. More detailed information is presented in the full set of more than 200 slides that can be found on the ISHLT Web site at www.ishlt.org/registries/.


Journal of Heart and Lung Transplantation | 2008

Registry of the International Society for Heart and Lung Transplantation: Twenty-fifth Official Adult Heart Transplant Report—2008

David O. Taylor; Leah B. Edwards; Paul Aurora; Jason D. Christie; Fabienne Dobbels; Richard Kirk; Axel Rahmel; Anna Y. Kucheryavaya; Marshall I. Hertz

e a t d t n this twenty-fifth official report of the International ociety for Heart and Lung Transplant (ISHLT) Registry, e present information regarding 80,000 heart translants performed worldwide. As in prior years’ reorts, we focus our principal analysis on recently ransplanted patients—rather than the entire cohort of eart recipients—to provide a contemporary represenation of the state of heart transplantation.

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Jason D. Christie

University of Pennsylvania

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Fabienne Dobbels

Katholieke Universiteit Leuven

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