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Lehua Chang

Merck & Co.

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Publication

Featured researches published by Lehua Chang.

ACS Medicinal Chemistry Letters | 2017

Design and Synthesis of Piperazine Sulfonamide Cores Leading to Highly Potent HIV-1 Protease Inhibitors

Christopher James Bungard; Peter D. Williams; Jurgen Schulz; Catherine M. Wiscount; M. Katharine Holloway; Marie Loughran; Jesse J. Manikowski; Hua-Poo Su; David Jonathan Bennett; Lehua Chang; Xin-jie Chu; Alejandro Crespo; Michael P. Dwyer; Kartik M. Keertikar; Gregori J. Morriello; Andrew Stamford; Sherman T. Waddell; Bin Zhong; Bin Hu; Tao Ji; Tracy L. Diamond; Carolyn Bahnck-Teets; Steven S. Carroll; John F. Fay; Xu Min; William J Morris; Jeanine Ballard; Michael D. Miller; John A. McCauley

Using the HIV-1 protease binding mode of MK-8718 and PL-100 as inspiration, a novel aspartate binding bicyclic piperazine sulfonamide core was designed and synthesized. The resulting HIV-1 protease inhibitor containing this core showed an 60-fold increase in enzyme binding affinity and a 10-fold increase in antiviral activity relative to MK-8718.

Archive | 2002

2-aminoquinoline compounds

Robert J. DeVita; Lehua Chang; Danny Chaung; Myle Hoang; Jinlong Jiang; Peter Lin; Andreas Sailer; Jonathan R. Young

Archive | 2010

Pyrrolidine-derived beta 3 adrenergic receptor agonists

Peter Lin; Lehua Chang; Scott D. Edmondson

Bioorganic & Medicinal Chemistry Letters | 2007

The discovery of potent, selective, and orally bioavailable hNK1 antagonists derived from pyrrolidine

Peter Lin; Lehua Chang; Robert J. DeVita; Jonathan R. Young; Ronsar Eid; Xinchun Tong; Song Zheng; Richard G. Ball; Nancy N. Tsou; Gary G. Chicchi; Marc M. Kurtz; Kwei-Lan C. Tsao; Alan Wheeldon; Emma J. Carlson; Wai-si Eng; H. Donald Burns; Richard Hargreaves; Sander G. Mills

Bioorganic & Medicinal Chemistry Letters | 2006

4-Aminoquinoline melanin-concentrating hormone 1-receptor (MCH1R) antagonists

Jinlong Jiang; Peter Lin; Myle Hoang; Lehua Chang; Carina Tan; Scott D. Feighner; Oksana C. Palyha; Donna L. Hreniuk; Jie Pan; Andreas Sailer; Nancy R. Morin; Douglas J. MacNeil; Andrew D. Howard; Lex H.T. Van der Ploeg; Mark T. Goulet; Robert J. DeVita

Archive | 2010

HYDROXYMETHYL PYRROLIDINE AS β3 ADRENOCEPTOR AGONIST

Richard A. Berger; Lehua Chang; Scott D. Edmondson; Stephen D. Goble; Sookhee Ha; Nam Fung Kar; Ihor E. Kopka; Bing Li; Gregori J. Morriello; Christopher Richard Moyes; Dong-Ming Shen; Liping Wang; Cheng Zhu; エドモンドソン，スコット，ディー．; カー，ナム，フォン．; ゴーブル，スティーブン，ディー．; コプカ，イーゴリー，イー．; シェン，ドン−ミン; チャン，レフア; チュ，チェン; ハ，スツキ，ニコール; バーガー，リチャード; モイーズ，クリス，アール．; モリエロ，グレゴリ，ジェイ．; リー，ビン; ワン，リピン

Archive | 2017

Substituted triazolo bicycliccompounds as pde2 inhibitors

Gregori J. Morriello; Lehua Chang; Ashley Foster; Yili Chen; Michael P. Dwyer; Zack Zhiqiang Guo; Ming Wang; Shimin Xu; Yingjian Bo; Jianmin Fu

Archive | 2014

SUBSTITUTED CYCLOPROPLY COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT

Scott D. Edmondson; Zhiqiang Guo; Harold B. Wood; Andrew W. Stamford; Michael W. Miller; Duane Demong; Gregori J. Morriello; Rajan Anand; Vincent J. Colandrea; Megan Macala; Milana Maletic; Cheng Zhu; Yuping Zhu; Wanying Sun; Kake Zhao; Yong Huang; Joel M. Harris; Lehua Chang; Nam Fung Kar; Zhiyong Hu; Liping Wang; Bowei Wang; Ping Liu; Jason W. Szewczyk; William B. Geiss

Archive | 2009

Hydroxyméthyl pyrrolidines en tant qu’agonistes de récepteur bêta 3 adrénergique

Richard A. Berger; Lehua Chang; Scott D. Edmondson; Stephen D. Goble; Sookhee Ha; Nam Fung Kar; Ihor E. Kopka; Bing Li; Gregori J. Morriello; Christopher Richard Moyes; Dong-Ming Shen; Liping Wang; Cheng Zhu

Archive | 2009

Hydroxyméthyl pyrrolidines en tant qu’agonistes des récepteurs adrénergiques bêta 3

Richard A. Berger; Lehua Chang; Scott D. Edmondson; Stephen D. Goble; Sookhee Ha; Nam Fung Kar; Ihor E. Kopka; Bing Li; Gregori J. Morriello; Christopher Richard Moyes; Dong-Ming Shen; Liping Wang; Cheng Zhu

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Gregori J. Morriello

Merck

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Peter Lin

Merck

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Robert J. DeVita

Merck

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Scott D. Edmondson

Merck

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Cheng Zhu

Merck

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Liping Wang

Merck

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Nam Fung Kar

Merck

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Bing Li

Merck

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Christopher Richard Moyes

Merck

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Dong-Ming Shen

Merck

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